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Anti-Metastatic Effects on Melanoma via Intravenous Administration of Anti-NF-κB siRNA Complexed with Functional Peptide-Modified Nano-Micelles.

Ibaraki H, Kanazawa T, Owada M, Iwaya K, Takashima Y, Seta Y.

Pharmaceutics. 2020 Jan 15;12(1). pii: E64. doi: 10.3390/pharmaceutics12010064.


Identification and characterization of a phenyl-thiazolyl-benzoic acid derivative as a novel RAR/RXR agonist.

Koshiishi C, Kanazawa T, Vangrevelinghe E, Honda T, Hatakeyama S.

Heliyon. 2019 Nov 19;5(11):e02849. doi: 10.1016/j.heliyon.2019.e02849. eCollection 2019 Nov.


Therapeutic Effects in a Transient Middle Cerebral Artery Occlusion Rat Model by Nose-To-Brain Delivery of Anti-TNF-Alpha siRNA with Cell-Penetrating Peptide-Modified Polymer Micelles.

Kanazawa T, Kurano T, Ibaraki H, Takashima Y, Suzuki T, Seta Y.

Pharmaceutics. 2019 Sep 15;11(9). pii: E478. doi: 10.3390/pharmaceutics11090478. Erratum in: Pharmaceutics. 2019 Dec 17;11(12):.


Anti-RelA siRNA-Encapsulated Flexible Liposome with Tight Junction-Opening Peptide as a Non-invasive Topical Therapeutic for Atopic Dermatitis.

Ibaraki H, Kanazawa T, Kurano T, Oogi C, Takashima Y, Seta Y.

Biol Pharm Bull. 2019;42(7):1216-1225. doi: 10.1248/bpb.b19-00259.


[Optimum Volume of Water Needed for the Paste State of Pediatric Powders: Considerations Based on Yield Values and Applications to Generic Medicine].

Fukuda H, Suzuki T, Hashizaki K, Yoshimura S, Kobayashi C, Omotani Y, Suzuki N, Kanazawa T, Fukami T, Yamamoto Y.

Yakugaku Zasshi. 2019;139(2):299-308. doi: 10.1248/yakushi.18-00182. Japanese.


Novel Methods for Intranasal Administration Under Inhalation Anesthesia to Evaluate Nose-to-Brain Drug Delivery.

Kanazawa T, Fukuda M, Suzuki N, Suzuki T.

J Vis Exp. 2018 Nov 14;(141). doi: 10.3791/58485.


[Development of Noninvasive Drug Delivery Systems to the Brain for the Treatment of Brain/Central Nervous System Diseases].

Kanazawa T.

Yakugaku Zasshi. 2018;138(4):443-450. doi: 10.1248/yakushi.17-00179. Review. Japanese.


Transdermal anti-nuclear kappaB siRNA therapy for atopic dermatitis using a combination of two kinds of functional oligopeptide.

Ibaraki H, Kanazawa T, Takashima Y, Okada H, Seta Y.

Int J Pharm. 2018 May 5;542(1-2):213-220. doi: 10.1016/j.ijpharm.2018.03.026. Epub 2018 Mar 15.


Imidazo[1,2-a]pyridin-6-yl-benzamide analogs as potent RAF inhibitors.

Smith A, Ni ZJ, Poon D, Huang Z, Chen Z, Zhang Q, Tandeske L, Merritt H, Shoemaker K, Chan J, Kaufman S, Huh K, Murray J, Appleton BA, Cowan-Jacob SW, Scheufler C, Kanazawa T, Jansen JM, Stuart D, Shafer CM.

Bioorg Med Chem Lett. 2017 Dec 1;27(23):5221-5224. doi: 10.1016/j.bmcl.2017.10.047. Epub 2017 Oct 20.


Intra-articular Retention and Anti-arthritic Effects in Collagen-Induced Arthritis Model Mice by Injectable Small Interfering RNA Containing Hydrogel.

Kanazawa T, Tamano K, Sogabe K, Endo T, Ibaraki H, Takashima Y, Seta Y.

Biol Pharm Bull. 2017;40(11):1929-1933. doi: 10.1248/bpb.b17-00481.


Enhancement of nose-to-brain delivery of hydrophilic macromolecules with stearate- or polyethylene glycol-modified arginine-rich peptide.

Kanazawa T, Kaneko M, Niide T, Akiyama F, Kakizaki S, Ibaraki H, Shiraishi S, Takashima Y, Suzuki T, Seta Y.

Int J Pharm. 2017 Sep 15;530(1-2):195-200. doi: 10.1016/j.ijpharm.2017.07.077. Epub 2017 Jul 27.


Systemic delivery of small interfering RNA targeting nuclear factor κB in mice with collagen-induced arthritis using arginine-histidine-cysteine based oligopeptide-modified polymer nanomicelles.

Kanazawa T, Endo T, Arima N, Ibaraki H, Takashima Y, Seta Y.

Int J Pharm. 2016 Dec 30;515(1-2):315-323. doi: 10.1016/j.ijpharm.2016.10.033. Epub 2016 Oct 17.


Development of an Innovative Intradermal siRNA Delivery System Using a Combination of a Functional Stearylated Cytoplasm-Responsive Peptide and a Tight Junction-Opening Peptide.

Ibaraki H, Kanazawa T, Takashima Y, Okada H, Seta Y.

Molecules. 2016 Sep 24;21(10). pii: E1279. doi: 10.3390/molecules21101279.


Topical Anti-Nuclear Factor-Kappa B Small Interfering RNA with Functional Peptides Containing Sericin-Based Hydrogel for Atopic Dermatitis.

Kanazawa T, Shizawa Y, Takeuchi M, Tamano K, Ibaraki H, Seta Y, Takashima Y, Okada H.

Pharmaceutics. 2015 Sep 7;7(3):294-304. doi: 10.3390/pharmaceutics7030294.


Functional peptide nanocarriers for delivery of novel anti-RelA RNA interference agents as a topical treatment of atopic dermatitis.

Kanazawa T, Hamasaki T, Endo T, Tamano K, Sogabe K, Seta Y, Ohgi T, Okada H.

Int J Pharm. 2015 Jul 15;489(1-2):261-7. doi: 10.1016/j.ijpharm.2015.05.003. Epub 2015 May 5.


Versatile nuclear localization signal-based oligopeptide as a gene vector.

Kanazawa T, Yamazaki M, Fukuda T, Takashima Y, Okada H.

Biol Pharm Bull. 2015;38(4):559-65. doi: 10.1248/bpb.b14-00706.


FOCUS--Development of a Global Communication and Modeling Platform for Applied and Computational Medicinal Chemists.

Stiefl N, Gedeck P, Chin D, Hunt P, Lindvall M, Spiegel K, Springer C, Biller S, Buenemann C, Kanazawa T, Kato M, Lewis R, Martin E, Polyakov V, Tommasi R, van Drie J, Vash B, Whitehead L, Xu Y, Abagyan R, Raush E, Totrov M.

J Chem Inf Model. 2015 Apr 27;55(4):896-908. doi: 10.1021/ci500598e. Epub 2015 Apr 13.


Brain delivery of small interfering ribonucleic acid and drugs through intranasal administration with nano-sized polymer micelles.

Kanazawa T.

Med Devices (Auckl). 2015 Jan 6;8:57-64. doi: 10.2147/MDER.S70856. eCollection 2015. Review.


Structure-based design of substituted piperidines as a new class of highly efficacious oral direct Renin inhibitors.

Ehara T, Irie O, Kosaka T, Kanazawa T, Breitenstein W, Grosche P, Ostermann N, Suzuki M, Kawakami S, Konishi K, Hitomi Y, Toyao A, Gunji H, Cumin F, Schiering N, Wagner T, Rigel DF, Webb RL, Maibaum J, Yokokawa F.

ACS Med Chem Lett. 2014 Apr 21;5(7):787-92. doi: 10.1021/ml500137b. eCollection 2014 Jul 10.

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