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Items: 1 to 20 of 46

1.

Blood-Brain Barrier Dysfunction and the Pathogenesis of Alzheimer's Disease.

Yamazaki Y, Kanekiyo T.

Int J Mol Sci. 2017 Sep 13;18(9). pii: E1965. doi: 10.3390/ijms18091965. Review.

2.

APOE ε4/ε4 diminishes neurotrophic function of human iPSC-derived astrocytes.

Zhao J, Davis MD, Martens YA, Shinohara M, Graff-Radford NR, Younkin SG, Wszolek ZK, Kanekiyo T, Bu G.

Hum Mol Genet. 2017 Jul 15;26(14):2690-2700. doi: 10.1093/hmg/ddx155.

PMID:
28444230
3.

Role of LRP1 in the pathogenesis of Alzheimer's disease: evidence from clinical and preclinical studies.

Shinohara M, Tachibana M, Kanekiyo T, Bu G.

J Lipid Res. 2017 Jul;58(7):1267-1281. doi: 10.1194/jlr.R075796. Epub 2017 Apr 4. Review.

PMID:
28381441
4.

Astrocytic LRP1 Mediates Brain Aβ Clearance and Impacts Amyloid Deposition.

Liu CC, Hu J, Zhao N, Wang J, Wang N, Cirrito JR, Kanekiyo T, Holtzman DM, Bu G.

J Neurosci. 2017 Apr 12;37(15):4023-4031. doi: 10.1523/JNEUROSCI.3442-16.2017. Epub 2017 Mar 8.

PMID:
28275161
5.

Subacute ibuprofen treatment rescues the synaptic and cognitive deficits in advanced-aged mice.

Rogers JT, Liu CC, Zhao N, Wang J, Putzke T, Yang L, Shinohara M, Fryer JD, Kanekiyo T, Bu G.

Neurobiol Aging. 2017 May;53:112-121. doi: 10.1016/j.neurobiolaging.2017.02.001. Epub 2017 Feb 9.

PMID:
28254590
6.

LRP1 modulates the microglial immune response via regulation of JNK and NF-κB signaling pathways.

Yang L, Liu CC, Zheng H, Kanekiyo T, Atagi Y, Jia L, Wang D, N'songo A, Can D, Xu H, Chen XF, Bu G.

J Neuroinflammation. 2016 Dec 8;13(1):304.

7.

Identification of plexin A4 as a novel clusterin receptor links two Alzheimer's disease risk genes.

Kang SS, Kurti A, Wojtas A, Baker KE, Liu CC, Kanekiyo T, Deming Y, Cruchaga C, Estus S, Bu G, Fryer JD.

Hum Mol Genet. 2016 Aug 15;25(16):3467-3475. doi: 10.1093/hmg/ddw188. Epub 2016 Jul 4.

8.

Apolipoprotein E as a Therapeutic Target in Alzheimer's Disease: A Review of Basic Research and Clinical Evidence.

Yamazaki Y, Painter MM, Bu G, Kanekiyo T.

CNS Drugs. 2016 Sep;30(9):773-89. doi: 10.1007/s40263-016-0361-4.

9.

Impact of sex and APOE4 on cerebral amyloid angiopathy in Alzheimer's disease.

Shinohara M, Murray ME, Frank RD, Shinohara M, DeTure M, Yamazaki Y, Tachibana M, Atagi Y, Davis MD, Liu CC, Zhao N, Painter MM, Petersen RC, Fryer JD, Crook JE, Dickson DW, Bu G, Kanekiyo T.

Acta Neuropathol. 2016 Aug;132(2):225-34. doi: 10.1007/s00401-016-1580-y. Epub 2016 May 14.

10.

Apolipoprotein E lipoprotein particles inhibit amyloid-β uptake through cell surface heparan sulphate proteoglycan.

Fu Y, Zhao J, Atagi Y, Nielsen HM, Liu CC, Zheng H, Shinohara M, Kanekiyo T, Bu G.

Mol Neurodegener. 2016 May 5;11(1):37. doi: 10.1186/s13024-016-0099-y.

11.

ABCA7 Deficiency Accelerates Amyloid-β Generation and Alzheimer's Neuronal Pathology.

Sakae N, Liu CC, Shinohara M, Frisch-Daiello J, Ma L, Yamazaki Y, Tachibana M, Younkin L, Kurti A, Carrasquillo MM, Zou F, Sevlever D, Bisceglio G, Gan M, Fol R, Knight P, Wang M, Han X, Fryer JD, Fitzgerald ML, Ohyagi Y, Younkin SG, Bu G, Kanekiyo T.

J Neurosci. 2016 Mar 30;36(13):3848-59. doi: 10.1523/JNEUROSCI.3757-15.2016.

12.

Neuronal heparan sulfates promote amyloid pathology by modulating brain amyloid-β clearance and aggregation in Alzheimer's disease.

Liu CC, Zhao N, Yamaguchi Y, Cirrito JR, Kanekiyo T, Holtzman DM, Bu G.

Sci Transl Med. 2016 Mar 30;8(332):332ra44. doi: 10.1126/scitranslmed.aad3650.

13.

APOE2 eases cognitive decline during Aging: Clinical and preclinical evaluations.

Shinohara M, Kanekiyo T, Yang L, Linthicum D, Shinohara M, Fu Y, Price L, Frisch-Daiello JL, Han X, Fryer JD, Bu G.

Ann Neurol. 2016 Mar 2. doi: 10.1002/ana.24628. [Epub ahead of print]

14.

The role of APOE in cerebrovascular dysfunction.

Tai LM, Thomas R, Marottoli FM, Koster KP, Kanekiyo T, Morris AW, Bu G.

Acta Neuropathol. 2016 May;131(5):709-23. doi: 10.1007/s00401-016-1547-z. Epub 2016 Feb 16. Review.

15.

Vascular Cell Senescence Contributes to Blood-Brain Barrier Breakdown.

Yamazaki Y, Baker DJ, Tachibana M, Liu CC, van Deursen JM, Brott TG, Bu G, Kanekiyo T.

Stroke. 2016 Apr;47(4):1068-77. doi: 10.1161/STROKEAHA.115.010835. Epub 2016 Feb 16.

16.

Rescuing effects of RXR agonist bexarotene on aging-related synapse loss depend on neuronal LRP1.

Tachibana M, Shinohara M, Yamazaki Y, Liu CC, Rogers J, Bu G, Kanekiyo T.

Exp Neurol. 2016 Mar;277:1-9. doi: 10.1016/j.expneurol.2015.12.003. Epub 2015 Dec 11.

17.

Frontotemporal dementia-associated N279K tau mutant disrupts subcellular vesicle trafficking and induces cellular stress in iPSC-derived neural stem cells.

Wren MC, Zhao J, Liu CC, Murray ME, Atagi Y, Davis MD, Fu Y, Okano HJ, Ogaki K, Strongosky AJ, Tacik P, Rademakers R, Ross OA, Dickson DW, Wszolek ZK, Kanekiyo T, Bu G.

Mol Neurodegener. 2015 Sep 15;10:46. doi: 10.1186/s13024-015-0042-7.

18.

Modulation of mitochondrial complex I activity averts cognitive decline in multiple animal models of familial Alzheimer's Disease.

Zhang L, Zhang S, Maezawa I, Trushin S, Minhas P, Pinto M, Jin LW, Prasain K, Nguyen TD, Yamazaki Y, Kanekiyo T, Bu G, Gateno B, Chang KO, Nath KA, Nemutlu E, Dzeja P, Pang YP, Hua DH, Trushina E.

EBioMedicine. 2015 Apr 1;2(4):294-305.

19.

Central role for PICALM in amyloid-β blood-brain barrier transcytosis and clearance.

Zhao Z, Sagare AP, Ma Q, Halliday MR, Kong P, Kisler K, Winkler EA, Ramanathan A, Kanekiyo T, Bu G, Owens NC, Rege SV, Si G, Ahuja A, Zhu D, Miller CA, Schneider JA, Maeda M, Maeda T, Sugawara T, Ichida JK, Zlokovic BV.

Nat Neurosci. 2015 Jul;18(7):978-87. doi: 10.1038/nn.4025. Epub 2015 May 25.

20.

Apolipoprotein E Inhibits Cerebrovascular Pericyte Mobility through a RhoA Protein-mediated Pathway.

Casey CS, Atagi Y, Yamazaki Y, Shinohara M, Tachibana M, Fu Y, Bu G, Kanekiyo T.

J Biol Chem. 2015 May 29;290(22):14208-17. doi: 10.1074/jbc.M114.625251. Epub 2015 Apr 22.

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