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Items: 1 to 20 of 89

1.

A thermoresponsive hydrophobically modified hydroxypropylmethylcellulose/cyclodextrin injectable hydrogel for the sustained release of drugs.

Okubo M, Iohara D, Anraku M, Higashi T, Uekama K, Hirayama F.

Int J Pharm. 2019 Dec 10;575:118845. doi: 10.1016/j.ijpharm.2019.118845. [Epub ahead of print]

PMID:
31836484
2.

Identification of candidate molecular targets of the novel antineoplastic antimitotic NP-10.

Yokoyama T, Yukuhiro M, Iwasaki Y, Tanaka C, Sankoda K, Fujiwara R, Shibuta A, Higashi T, Motoyama K, Arima H, Yoshida K, Sugimoto N, Morimoto H, Kosako H, Ohshima T, Fujita M.

Sci Rep. 2019 Nov 14;9(1):16825. doi: 10.1038/s41598-019-53259-2.

3.

Hepatocyte-Targeted Delivery of siRNA Polyplex with PEG-Modified Lactosylated Dendrimer/Cyclodextrin Conjugates for Transthyretin-Related Amyloidosis Therapy.

Hayashi Y, Higashi T, Motoyama K, Jono H, Ando Y, Onodera R, Arima H.

Biol Pharm Bull. 2019;42(10):1679-1688. doi: 10.1248/bpb.b19-00278.

4.

A comprehensive understanding of lowly-hydrolyzed polyvinyl alcohol-based ternary solid dispersions with the use of a combined mixture-process design.

Mori Y, Higashi T, Motoyama K, Ishida M, Onodera R, Arima H.

Drug Dev Ind Pharm. 2019 Oct;45(10):1599-1609. doi: 10.1080/03639045.2019.1640720. Epub 2019 Aug 13.

PMID:
31271320
5.

In vivo Efficacy and Safety Evaluation of Lactosyl-β-cyclodextrin as a Therapeutic Agent for Hepatomegaly in Niemann-Pick Type C Disease.

Maeda Y, Motoyama K, Nishiyama R, Higashi T, Onodera R, Nakamura H, Takeo T, Nakagata N, Yamada Y, Ishitsuka Y, Kondo Y, Irie T, Era T, Arima H.

Nanomaterials (Basel). 2019 May 25;9(5). pii: E802. doi: 10.3390/nano9050802.

6.

In Vitro and In Vivo Co-delivery of siRNA and Doxorubicin by Folate-PEG-Appended Dendrimer/Glucuronylglucosyl-β-Cyclodextrin Conjugate.

Mohammed AFA, Higashi T, Motoyama K, Ohyama A, Onodera R, Khaled KA, Sarhan HA, Hussein AK, Arima H.

AAPS J. 2019 Apr 16;21(4):54. doi: 10.1208/s12248-019-0327-9.

PMID:
30993472
7.

Cyclodextrin-Based Molecular Accessories for Drug Discovery and Drug Delivery.

Higashi T.

Chem Pharm Bull (Tokyo). 2019;67(4):289-298. doi: 10.1248/cpb.c18-00735. Review.

8.

Therapeutic Potential of Polyamidoamine Dendrimer for Amyloidogenic Transthyretin Amyloidosis.

Inoue M, Ueda M, Higashi T, Anno T, Fujisawa K, Motoyama K, Mizuguchi M, Ando Y, Jono H, Arima H.

ACS Chem Neurosci. 2019 May 15;10(5):2584-2590. doi: 10.1021/acschemneuro.9b00059. Epub 2019 Mar 26.

PMID:
30912637
9.

In Vitro and In Vivo Evaluation of 6-O-α-Maltosyl-β-Cyclodextrin as a Potential Therapeutic Agent Against Niemann-Pick Disease Type C.

Yasmin N, Ishitsuka Y, Fukaura M, Yamada Y, Nakahara S, Ishii A, Kondo Y, Takeo T, Nakagata N, Motoyama K, Higashi T, Okada Y, Nishikawa J, Ichikawa A, Iohara D, Hirayama F, Higaki K, Ohno K, Matsuo M, Irie T.

Int J Mol Sci. 2019 Mar 6;20(5). pii: E1152. doi: 10.3390/ijms20051152.

10.

[Potential Use of Sacran for Dermal and Oral Preparations].

Arima H, Motoyama K, Higashi T.

Yakugaku Zasshi. 2019;139(3):385-391. doi: 10.1248/yakushi.18-00177-5. Review. Japanese.

11.

[Supramolecular Pharmaceutical Sciences: A Novel Concept for Future Pharmaceutical Sciences].

Higashi T, Motoyama K, Arima H.

Yakugaku Zasshi. 2019;139(2):175-183. doi: 10.1248/yakushi.18-00168-4. Review. Japanese.

12.

[Supramolecular Pharmaceutical Sciences: A Novel Concept Combining Pharmaceutical Sciences and Supramolecular Chemistry].

Iohara D, Higashi T.

Yakugaku Zasshi. 2019;139(2):141-142. doi: 10.1248/yakushi.18-00168-F. Japanese. No abstract available.

13.

DAMP-Inducing Adjuvant and PAMP Adjuvants Parallelly Enhance Protective Type-2 and Type-1 Immune Responses to Influenza Split Vaccination.

Hayashi T, Momota M, Kuroda E, Kusakabe T, Kobari S, Makisaka K, Ohno Y, Suzuki Y, Nakagawa F, Lee MSJ, Coban C, Onodera R, Higashi T, Motoyama K, Ishii KJ, Arima H.

Front Immunol. 2018 Nov 20;9:2619. doi: 10.3389/fimmu.2018.02619. eCollection 2018.

14.

Theoretical and practical evaluation of lowly hydrolyzed polyvinyl alcohol as a potential carrier for hot-melt extrusion.

Mori Y, Motoyama K, Ishida M, Onodera R, Higashi T, Arima H.

Int J Pharm. 2019 Jan 30;555:124-134. doi: 10.1016/j.ijpharm.2018.11.037. Epub 2018 Nov 15.

PMID:
30448311
15.

Identification of molecular-interaction sites between lowly hydrolyzed polyvinyl alcohols and indomethacin by NMR spectroscopy.

Mori Y, Takahashi M, Ohno Y, Okura R, Ishida M, Higashi T, Motoyama K, Arima H.

Int J Pharm. 2018 Oct 5;549(1-2):456-465. doi: 10.1016/j.ijpharm.2018.08.018. Epub 2018 Aug 12.

PMID:
30110620
16.

[Potential Use of Sacran Hydrogels as Wound Dressing Material].

Motoyama K, Higashi T, Okajima MK, Kaneko T, Arima H.

Yakugaku Zasshi. 2018;138(4):517-520. doi: 10.1248/yakushi.17-00201-5. Review. Japanese.

17.

[Anti-inflammatory Effect of Sacran on Atopic Dermatitis].

Arima H, Motoyama K, Higashi T, Fukushima S, Ihn H.

Yakugaku Zasshi. 2018;138(4):509-515. doi: 10.1248/yakushi.17-00201-4. Review. Japanese.

18.

Supramolecular Pharmaceutical Sciences: A Novel Concept Combining Pharmaceutical Sciences and Supramolecular Chemistry with a Focus on Cyclodextrin-Based Supermolecules.

Higashi T, Iohara D, Motoyama K, Arima H.

Chem Pharm Bull (Tokyo). 2018;66(3):207-216. doi: 10.1248/cpb.c17-00765. Review.

19.

Dual targeting system by supramolecular complex of folate-conjugated methyl-β-cyclodextrin with adamantane-grafted hyaluronic acid for the treatment of colorectal cancer.

Elamin KM, Motoyama K, Higashi T, Yamashita Y, Tokuda A, Arima H.

Int J Biol Macromol. 2018 Jul 1;113:386-394. doi: 10.1016/j.ijbiomac.2018.02.149. Epub 2018 Feb 24.

PMID:
29486262
20.

Supramolecular Complex of Methyl-β-cyclodextrin with Adamantane-Grafted Hyaluronic Acid as a Novel Antitumor Agent.

Elamin KM, Yamashita Y, Higashi T, Motoyama K, Arima H.

Chem Pharm Bull (Tokyo). 2018 Mar 1;66(3):277-285. doi: 10.1248/cpb.c17-00824. Epub 2017 Dec 22.

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