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Materials (Basel). 2018 Aug 8;11(8). pii: E1378. doi: 10.3390/ma11081378.

Synthesis of Heart/Dumbbell-Like CuO Functional Nanostructures for the Development of Uric Acid Biosensor.

Author information

1
State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Renmin St. 5625, Changchun 130022, China. zaffar_ibupoto@yahoo.com.
2
Institute of Chemistry, University of Sindh, 76080 Jamshoro, Pakistan. zaffar_ibupoto@yahoo.com.
3
Department of Science and Technology, Campus Norrköping, Linköping University, SE-60174 Norrköping, Sweden. aneela.tahira@liu.se.
4
Department of Anaesthesia Liaquat, University of Medial and Health Sciences, 76080 Jamshoro, Pakistan. hamid.raza@gmail.com.
5
Institute of Chemistry, University of Sindh, 76080 Jamshoro, Pakistan. gulzaralichemist@gmail.com.
6
School of Life Sciences, Tsinghua University, Beijing 100084, China. aftab_k97@yahoo.com.
7
Institute of Plant Sciences, University of Sindh, 76080 Jamshoro, Pakistan. nabila_jilani@hotmail.com.
8
Institute of Chemistry, University of Sindh, 76080 Jamshoro, Pakistan. arfana30@gmail.com.
9
State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Renmin St. 5625, Changchun 130022, China. congyu@ciac.jl.cn.
10
Department of Science and Technology, Campus Norrköping, Linköping University, SE-60174 Norrköping, Sweden. magnus.willander@liu.se.

Abstract

It is always demanded to prepare a nanostructured material with prominent functional properties for the development of a new generation of devices. This study is focused on the synthesis of heart/dumbbell-like CuO nanostructures using a low-temperature aqueous chemical growth method with vitamin B12 as a soft template and growth directing agent. CuO nanostructures are characterized by scanning electron microscopy (SEM), X-ray diffraction (XRD), and X-ray photoelectron spectroscopy (XPS) techniques. CuO nanostructures are heart/dumbbell like in shape, exhibit high crystalline quality as demonstrated by XRD, and have no impurity as confirmed by XPS. Apparently, CuO material seems to be porous in structure, which can easily carry large amount of enzyme molecules, thus enhanced performance is shown for the determination of uric acid. The working linear range of the biosensor is 0.001 mM to 10 mM with a detection limit of 0.0005 mM and a sensitivity of 61.88 mV/decade. The presented uric acid biosensor is highly stable, repeatable, and reproducible. The analytical practicality of the proposed uric acid biosensor is also monitored. The fabrication methodology is inexpensive, simple, and scalable, which ensures the capitalization of the developed uric acid biosensor for commercialization. Also, CuO material can be used for various applications such as solar cells, lithium ion batteries, and supercapacitors.

KEYWORDS:

CuO nanostructures; potentiometric response; uric acid biosensor; vitamin B12

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