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Simulated body fluid and the novel bioactive materials derived from it.

Kokubo T, Yamaguchi S.

J Biomed Mater Res A. 2019 May;107(5):968-977. doi: 10.1002/jbm.a.36620. Epub 2019 Feb 13. Review.


Improved bioactivity of GUMMETAL®, Ti59Nb36Ta2Zr3O0.3, via formation of nanostructured surfaces.

Divakarla SK, Yamaguchi S, Kokubo T, Han DW, Lee JH, Chrzanowski W.

J Tissue Eng. 2018 May 15;9:2041731418774178. doi: 10.1177/2041731418774178. eCollection 2018 Jan-Dec.


Bioactive pedicle screws prepared by chemical and heat treatments improved biocompatibility and bone-bonding ability in canine lumbar spines.

Akeda K, Yamaguchi S, Matsushita T, Kokubo T, Murata K, Takegami N, Matsumine A, Sudo A.

PLoS One. 2018 May 7;13(5):e0196766. doi: 10.1371/journal.pone.0196766. eCollection 2018.


Improvement in the measurement error of the specific binding ratio in dopamine transporter SPECT imaging due to exclusion of the cerebrospinal fluid fraction using the threshold of voxel RI count.

Mizumura S, Nishikawa K, Murata A, Yoshimura K, Ishii N, Kokubo T, Morooka M, Kajiyama A, Terahara A.

Ann Nucl Med. 2018 May;32(4):288-296. doi: 10.1007/s12149-018-1249-9. Epub 2018 Mar 15.


Strontium and magnesium ions released from bioactive titanium metal promote early bone bonding in a rabbit implant model.

Okuzu Y, Fujibayashi S, Yamaguchi S, Yamamoto K, Shimizu T, Sono T, Goto K, Otsuki B, Matsushita T, Kokubo T, Matsuda S.

Acta Biomater. 2017 Nov;63:383-392. doi: 10.1016/j.actbio.2017.09.019. Epub 2017 Sep 14.


In vivo experimental study of anterior cervical fusion using bioactive polyetheretherketone in a canine model.

Shimizu T, Fujibayashi S, Yamaguchi S, Otsuki B, Okuzu Y, Matsushita T, Kokubo T, Matsuda S.

PLoS One. 2017 Sep 8;12(9):e0184495. doi: 10.1371/journal.pone.0184495. eCollection 2017.


Two-in-One Biointerfaces-Antimicrobial and Bioactive Nanoporous Gallium Titanate Layers for Titanium Implants.

Yamaguchi S, Nath S, Sugawara Y, Divakarla K, Das T, Manos J, Chrzanowski W, Matsushita T, Kokubo T.

Nanomaterials (Basel). 2017 Aug 20;7(8). pii: E229. doi: 10.3390/nano7080229.


Fabrication of dense α-alumina layer on Ti-6Al-4V alloy hybrid for bearing surfaces of artificial hip joint.

Khanna R, Kokubo T, Matsushita T, Takadama H.

Mater Sci Eng C Mater Biol Appl. 2016 Dec 1;69:1229-39. doi: 10.1016/j.msec.2016.08.025. Epub 2016 Aug 12.


Novel bioactive materials developed by simulated body fluid evaluation: Surface-modified Ti metal and its alloys.

Kokubo T, Yamaguchi S.

Acta Biomater. 2016 Oct 15;44:16-30. doi: 10.1016/j.actbio.2016.08.013. Epub 2016 Aug 10. Review.


Bioactivity of sol-gel-derived TiO2 coating on polyetheretherketone: In vitro and in vivo studies.

Shimizu T, Fujibayashi S, Yamaguchi S, Yamamoto K, Otsuki B, Takemoto M, Tsukanaka M, Kizuki T, Matsushita T, Kokubo T, Matsuda S.

Acta Biomater. 2016 Apr 15;35:305-17. doi: 10.1016/j.actbio.2016.02.007. Epub 2016 Feb 6.


Bioactive treatment promotes osteoblast differentiation on titanium materials fabricated by selective laser melting technology.

Tsukanaka M, Fujibayashi S, Takemoto M, Matsushita T, Kokubo T, Nakamura T, Sasaki K, Matsuda S.

Dent Mater J. 2016;35(1):118-25. doi: 10.4012/dmj.2015-127.


Effect of pore size on bone ingrowth into porous titanium implants fabricated by additive manufacturing: An in vivo experiment.

Taniguchi N, Fujibayashi S, Takemoto M, Sasaki K, Otsuki B, Nakamura T, Matsushita T, Kokubo T, Matsuda S.

Mater Sci Eng C Mater Biol Appl. 2016 Feb;59:690-701. doi: 10.1016/j.msec.2015.10.069. Epub 2015 Oct 28.


Growth of Novel Ceramic Layers on Metals via Chemical and Heat Treatments for Inducing Various Biological Functions.

Kokubo T, Yamaguchi S.

Front Bioeng Biotechnol. 2015 Oct 27;3:176. doi: 10.3389/fbioe.2015.00176. eCollection 2015. Review.


In vivo study of the early bone-bonding ability of Ti meshes formed with calcium titanate via chemical treatments.

Tian Y, Fujibayashi S, Yamaguchi S, Matsushita T, Kokubo T, Matsuda S.

J Mater Sci Mater Med. 2015 Dec;26(12):271. doi: 10.1007/s10856-015-5612-2. Epub 2015 Oct 29.


Novel artificial hip joint: A layer of alumina on Ti-6Al-4V alloy formed by micro-arc oxidation.

Khanna R, Kokubo T, Matsushita T, Nomura Y, Nose N, Oomori Y, Yoshida T, Wakita K, Takadama H.

Mater Sci Eng C Mater Biol Appl. 2015 Oct;55:393-400. doi: 10.1016/j.msec.2015.05.021. Epub 2015 May 9.


Bioactive titanate layers formed on titanium and its alloys by simple chemical and heat treatments.

Kokubo T, Yamaguchi S.

Open Biomed Eng J. 2015 Feb 27;9:29-41. doi: 10.2174/1874120701509010029. eCollection 2015.


A unified in vitro evaluation for apatite-forming ability of bioactive glasses and their variants.

Maçon AL, Kim TB, Valliant EM, Goetschius K, Brow RK, Day DE, Hoppe A, Boccaccini AR, Kim IY, Ohtsuki C, Kokubo T, Osaka A, Vallet-Regí M, Arcos D, Fraile L, Salinas AJ, Teixeira AV, Vueva Y, Almeida RM, Miola M, Vitale-Brovarone C, Verné E, Höland W, Jones JR.

J Mater Sci Mater Med. 2015 Feb;26(2):115. doi: 10.1007/s10856-015-5403-9. Epub 2015 Feb 11.


Apatite-forming PEEK with TiO2 surface layer coating.

Kizuki T, Matsushita T, Kokubo T.

J Mater Sci Mater Med. 2015 Jan;26(1):5359. doi: 10.1007/s10856-014-5359-1. Epub 2015 Jan 15.


Antibacterial and bioactive calcium titanate layers formed on Ti metal and its alloys.

Kizuki T, Matsushita T, Kokubo T.

J Mater Sci Mater Med. 2014 Jul;25(7):1737-46. doi: 10.1007/s10856-014-5201-9. Epub 2014 Mar 29.


Osteoinduction on acid and heat treated porous Ti metal samples in canine muscle.

Kawai T, Takemoto M, Fujibayashi S, Akiyama H, Tanaka M, Yamaguchi S, Pattanayak DK, Doi K, Matsushita T, Nakamura T, Kokubo T, Matsuda S.

PLoS One. 2014 Feb 10;9(2):e88366. doi: 10.1371/journal.pone.0088366. eCollection 2014.

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