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Items: 1 to 20 of 21


Bone-marrow derived mesenchymal stromal cells infusion in therapy refractory juvenile idiopathic arthritis patients.

Swart JF, de Roock S, Nievelstein RAJ, Slaper-Cortenbach ICM, Boelens JJ, Wulffraat NM.

Rheumatology (Oxford). 2019 Apr 27. pii: kez157. doi: 10.1093/rheumatology/kez157. [Epub ahead of print]


Molecular signature characterisation of different inflammatory phenotypes of systemic juvenile idiopathic arthritis.

Gohar F, McArdle A, Jones M, Callan N, Hernandez B, Kessel C, Miranda-Garcia M, Lavric M, Holzinger D, Pretzer C, Lainka E, Vastert SJ, de Roock S, FitzGerald O, Pennington SR, Foell D.

Ann Rheum Dis. 2019 Aug;78(8):1107-1113. doi: 10.1136/annrheumdis-2019-215051. Epub 2019 Apr 20.


Treatment to Target Using Recombinant Interleukin-1 Receptor Antagonist as First-Line Monotherapy in New-Onset Systemic Juvenile Idiopathic Arthritis: Results From a Five-Year Follow-Up Study.

Ter Haar NM, van Dijkhuizen EHP, Swart JF, van Royen-Kerkhof A, El Idrissi A, Leek AP, de Jager W, de Groot MCH, Haitjema S, Holzinger D, Foell D, van Loosdregt J, Wulffraat NM, de Roock S, Vastert SJ.

Arthritis Rheumatol. 2019 Jul;71(7):1163-1173. doi: 10.1002/art.40865. Epub 2019 May 25.


Juvenile Arthritis Patients Suffering from Chronic Inflammation Have Increased Activity of Both IDO and GTP-CH1 Pathways But Decreased BH4 Efficacy: Implications for Well-Being, Including Fatigue, Cognitive Impairment, Anxiety, and Depression.

Korte-Bouws GAH, Albers E, Voskamp M, Hendriksen H, de Leeuw LR, Güntürkün O, de Roock S, Vastert SJ, Korte SM.

Pharmaceuticals (Basel). 2019 Jan 8;12(1). pii: E9. doi: 10.3390/ph12010009.


Reversal of Sepsis-Like Features of Neutrophils by Interleukin-1 Blockade in Patients With Systemic-Onset Juvenile Idiopathic Arthritis.

Ter Haar NM, Tak T, Mokry M, Scholman RC, Meerding JM, de Jager W, Verwoerd A, Foell D, Vogl T, Roth J, Leliefeld PHC, van Loosdregt J, Koenderman L, Vastert SJ, de Roock S.

Arthritis Rheumatol. 2018 Jun;70(6):943-956. doi: 10.1002/art.40442. Epub 2018 May 7.


Clinical Juvenile Arthritis Disease Activity Score proves to be a useful tool in treat-to-target therapy in juvenile idiopathic arthritis.

Swart JF, van Dijkhuizen EHP, Wulffraat NM, de Roock S.

Ann Rheum Dis. 2018 Mar;77(3):336-342. doi: 10.1136/annrheumdis-2017-212104. Epub 2017 Nov 14.


Increased autophagy contributes to the inflammatory phenotype of juvenile idiopathic arthritis synovial fluid T cells.

Peeters JGC, de Graeff N, Lotz M, Albani S, de Roock S, van Loosdregt J.

Rheumatology (Oxford). 2017 Oct 1;56(10):1694-1699. doi: 10.1093/rheumatology/kex227.


Varicella vaccination elicits a humoral and cellular response in children with rheumatic diseases using immune suppressive treatment.

Groot N, Pileggi G, Sandoval CB, Grein I, Berbers G, Ferriani VPL, Wulffraat N, de Roock S.

Vaccine. 2017 May 15;35(21):2818-2822. doi: 10.1016/j.vaccine.2017.04.015. Epub 2017 Apr 12.


The human microbiome and juvenile idiopathic arthritis.

Verwoerd A, Ter Haar NM, de Roock S, Vastert SJ, Bogaert D.

Pediatr Rheumatol Online J. 2016 Sep 20;14(1):55. doi: 10.1186/s12969-016-0114-4. Review.


Understanding inflammation in juvenile idiopathic arthritis: How immune biomarkers guide clinical strategies in the systemic onset subtype.

Swart JF, de Roock S, Prakken BJ.

Eur J Immunol. 2016 Sep;46(9):2068-77. doi: 10.1002/eji.201546092. Review.


Autoimmune disease-associated gene expression is reduced by BET-inhibition.

Peeters JG, Vervoort SJ, Mijnheer G, de Roock S, Vastert SJ, Nieuwenhuis EE, van Wijk F, Prakken BJ, Mokry M, van Loosdregt J.

Genom Data. 2015 Nov 7;7:14-7. doi: 10.1016/j.gdata.2015.11.004. eCollection 2016 Mar.


Inhibition of Super-Enhancer Activity in Autoinflammatory Site-Derived T Cells Reduces Disease-Associated Gene Expression.

Peeters JG, Vervoort SJ, Tan SC, Mijnheer G, de Roock S, Vastert SJ, Nieuwenhuis EE, van Wijk F, Prakken BJ, Creyghton MP, Coffer PJ, Mokry M, van Loosdregt J.

Cell Rep. 2015 Sep 29;12(12):1986-96. doi: 10.1016/j.celrep.2015.08.046. Epub 2015 Sep 17.


A novel human STAT3 mutation presents with autoimmunity involving Th17 hyperactivation.

Wienke J, Janssen W, Scholman R, Spits H, van Gijn M, Boes M, van Montfrans J, Moes N, de Roock S.

Oncotarget. 2015 Aug 21;6(24):20037-42.


Developing clinically relevant biomarkers in inflammatory arthritis: A multiplatform approach for serum candidate protein discovery.

McArdle A, Qasim Butt A, Szentpetery A, de Jager W, de Roock S, FitzGerald O, Pennington SR.

Proteomics Clin Appl. 2016 Jun;10(6):691-8. doi: 10.1002/prca.201500046. Epub 2015 Nov 9.


Elevated Th17 response in infants undergoing respiratory viral infection.

Stoppelenburg AJ, de Roock S, Hennus MP, Bont L, Boes M.

Am J Pathol. 2014 May;184(5):1274-9. doi: 10.1016/j.ajpath.2014.01.033. Epub 2014 Mar 17.


TH17 differentiation capacity develops within the first 3 months of life.

Dijkstra KK, Hoeks SB, Prakken BJ, de Roock S.

J Allergy Clin Immunol. 2014 Mar;133(3):891-4.e5. doi: 10.1016/j.jaci.2013.09.022. Epub 2013 Nov 1. No abstract available.


Defective TH17 development in human neonatal T cells involves reduced RORC2 mRNA content.

de Roock S, Stoppelenburg AJ, Scholman R, Hoeks SBEA, Meerding J, Prakken BJ, Boes M.

J Allergy Clin Immunol. 2013 Sep;132(3):754-756.e3. doi: 10.1016/j.jaci.2013.04.014. Epub 2013 May 29. No abstract available.


Cord blood CD4+ T cells respond to self heat shock protein 60 (HSP60).

Aalberse JA, Kapitein B, de Roock S, Klein MR, de Jager W, van der Zee R, Hoekstra MO, van Wijk F, Prakken BJ.

PLoS One. 2011;6(9):e24119. doi: 10.1371/journal.pone.0024119. Epub 2011 Sep 13.


Critical role for programmed death 1 signaling and protein kinase B in augmented regulatory T-cell induction in cord blood.

de Roock S, Hoeks SB, Meurs L, Steur A, Hoekstra MO, Prakken BJ, Boes M, de Kleer IM.

J Allergy Clin Immunol. 2011 Dec;128(6):1369-71. doi: 10.1016/j.jaci.2011.08.006. Epub 2011 Aug 25. No abstract available.


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