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Items: 1 to 20 of 56


Longitudinal PET Imaging of α7 Nicotinic Acetylcholine Receptors with [18F]ASEM in a Rat Model of Parkinson's Disease.

Vetel S, Vercouillie J, Buron F, Vergote J, Tauber C, Busson J, Chicheri G, Routier S, Sérrière S, Chalon S.

Mol Imaging Biol. 2019 Jul 8. doi: 10.1007/s11307-019-01400-y. [Epub ahead of print]


Bis(het)aryl-1,2,3-triazole quinuclidines as α7 nicotinic acetylcholine receptor ligands: Synthesis, structure affinity relationships, agonism activity, [18F]-radiolabeling and PET study in rats.

Ouach A, Vercouillie J, Bertrand E, Rodrigues N, Pin F, Serriere S, Boiaryna L, Chartier A, Percina N, Tangpong P, Gulhan Z, Mothes C, Deloye JB, Guilloteau D, Page G, Suzenet F, Buron F, Chalon S, Routier S.

Eur J Med Chem. 2019 Oct 1;179:449-469. doi: 10.1016/j.ejmech.2019.06.049. Epub 2019 Jun 27.


Preparation, Characterization and Wound Healing Effects of New Membranes Based on Chitosan, Hyaluronic Acid and Arginine Derivatives.

Iacob AT, Drăgan M, Ghețu N, Pieptu D, Vasile C, Buron F, Routier S, Giusca SE, Caruntu ID, Profire L.

Polymers (Basel). 2018 Jun 2;10(6). pii: E607. doi: 10.3390/polym10060607.


Design, biological evaluation and X-ray crystallography of nanomolar multifunctional ligands targeting simultaneously acetylcholinesterase and glycogen synthase kinase-3.

Oukoloff K, Coquelle N, Bartolini M, Naldi M, Le Guevel R, Bach S, Josselin B, Ruchaud S, Catto M, Pisani L, Denora N, Iacobazzi RM, Silman I, Sussman JL, Buron F, Colletier JP, Jean L, Routier S, Renard PY.

Eur J Med Chem. 2019 Apr 15;168:58-77. doi: 10.1016/j.ejmech.2018.12.063. Epub 2019 Feb 13.


Formulation and Characterization of New Polymeric Systems Based on Chitosan and Xanthine Derivatives with Thiazolidin-4-One Scaffold.

Constantin SM, Buron F, Routier S, Vasincu IM, Apotrosoaei M, Lupașcu F, Confederat L, Tuchilus C, Constantin MT, Sava A, Profire L.

Materials (Basel). 2019 Feb 13;12(4). pii: E558. doi: 10.3390/ma12040558.


Design of selective COX-2 inhibitors in the (aza)indazole series. Chemistry, in vitro studies, radiochemistry and evaluations in rats of a [18F] PET tracer.

Elie J, Vercouillie J, Arlicot N, Lemaire L, Bidault R, Bodard S, Hosselet C, Deloye JB, Chalon S, Emond P, Guilloteau D, Buron F, Routier S.

J Enzyme Inhib Med Chem. 2019 Dec;34(1):1-7. doi: 10.1080/14756366.2018.1501043.


Regioselective Synthesis of New 2,4-(Het)aryl-3H-pyrido[1',2':1,5]pyrazolo[4,3-d]pyrimidines Involving Palladium-Catalyzed Cross-Coupling Reactions.

Ejjoummany A, Belaroussi R, El Hakmaoui A, Akssira M, Guillaumet G, Buron F, Routier S.

Molecules. 2018 Oct 23;23(11). pii: E2740. doi: 10.3390/molecules23112740.


Synthesis of [1,3,4]Thiadiazolo[3',2':1,2]imidazo[4,5-c]quinolines including Pictet-Spengler Reaction and Exploration of Their C-2 Reactivity through SNAr.

Place M, Copin C, Apotrosoaei M, Constantin S, Vasincu IM, Profire L, Buron F, Routier S.

J Org Chem. 2017 Dec 15;82(24):13700-13707. doi: 10.1021/acs.joc.7b02565. Epub 2017 Nov 21.


Perinatal Exposure to the Cyanotoxin β-N-Méthylamino-L-Alanine (BMAA) Results in Long-Lasting Behavioral Changes in Offspring-Potential Involvement of DNA Damage and Oxidative Stress.

Laugeray A, Oummadi A, Jourdain C, Feat J, Meyer-Dilhet G, Menuet A, Plé K, Gay M, Routier S, Mortaud S, Guillemin GJ.

Neurotox Res. 2018 Jan;33(1):87-112. doi: 10.1007/s12640-017-9802-1. Epub 2017 Sep 6.


Neuroprotective effect of the alpha 7 nicotinic receptor agonist PHA 543613 in an in vivo excitotoxic adult rat model.

Foucault-Fruchard L, Doméné A, Page G, Windsor M, Emond P, Rodrigues N, Dollé F, Damont A, Buron F, Routier S, Chalon S, Antier D.

Neuroscience. 2017 Jul 25;356:52-63. doi: 10.1016/j.neuroscience.2017.05.019. Epub 2017 May 18.


Penicillinase-resistant antibiotics induce non-immune-mediated cholestasis through HSP27 activation associated with PKC/P38 and PI3K/AKT signaling pathways.

Burban A, Sharanek A, Hüe R, Gay M, Routier S, Guillouzo A, Guguen-Guillouzo C.

Sci Rep. 2017 May 12;7(1):1815. doi: 10.1038/s41598-017-01171-y.


Synthesis and Antiproliferative Effect of Ethyl 4-[4-(4-Substituted Piperidin-1-yl)]benzylpyrrolo[1,2-a]quinoxalinecarboxylate Derivatives on Human Leukemia Cells.

Desplat V, Vincenzi M, Lucas R, Moreau S, Savrimoutou S, Rubio S, Pinaud N, Bigat D, Enriquez E, Marchivie M, Routier S, Sonnet P, Rossi F, Ronga L, Guillon J.

ChemMedChem. 2017 Jun 21;12(12):940-953. doi: 10.1002/cmdc.201700049. Epub 2017 Apr 5.


Synthesis and biological evaluation of the new 1,3-dimethylxanthine derivatives with thiazolidine-4-one scaffold.

Constantin S, Lupascu FG, Apotrosoaei M, Vasincu IM, Lupascu D, Buron F, Routier S, Profire L.

Chem Cent J. 2017 Feb 1;11:12. doi: 10.1186/s13065-017-0241-0. eCollection 2017.


Controlled Dimroth Rearrangement in the Suzuki-Miyaura Cross Coupling of Triazolopyridopyrimidines.

Champiré A, Vala C, Laabid A, Benharref A, Marchivie M, Plé K, Routier S.

J Org Chem. 2016 Dec 16;81(24):12506-12513. Epub 2016 Dec 5.


30ièmes Journées Franco-Belges de Pharmacochimie.

Aci-Sèche S, Buron F, Plé K, Robin L, Suzenet F, Routier S.

Pharmaceuticals (Basel). 2016 Nov 18;9(4). pii: E73.


Novel optimization of valmerins (tetrahydropyrido[1,2-a]isoindolones) as potent dual CDK5/GSK3 inhibitors.

Ouach A, Boulahjar R, Vala C, Bourg S, Bonnet P, Guguen-Guillouzo C, Ravache M, Le Guevel R, Lozach O, Lazar S, Troin Y, Meijer L, Ruchaud S, Akssira M, Guillaumet G, Routier S.

Eur J Med Chem. 2016 Jun 10;115:311-25. doi: 10.1016/j.ejmech.2016.02.072. Epub 2016 Mar 2.


Synthesis and evaluation of the cytotoxic activity of novel ethyl 4-[4-(4-substitutedpiperidin-1-yl)]benzyl-phenylpyrrolo[1,2-a]quinoxaline-carboxylate derivatives in myeloid and lymphoid leukemia cell lines.

Desplat V, Vincenzi M, Lucas R, Moreau S, Savrimoutou S, Pinaud N, Lesbordes J, Peyrilles E, Marchivie M, Routier S, Sonnet P, Rossi F, Ronga L, Guillon J.

Eur J Med Chem. 2016 May 4;113:214-27. doi: 10.1016/j.ejmech.2016.02.047. Epub 2016 Feb 20.


Synthesis and biological evaluation of new 1,3-thiazolidine-4-one derivatives of nitro-l-arginine methyl ester.

Pânzariu AT, Apotrosoaei M, Vasincu IM, Drăgan M, Constantin S, Buron F, Routier S, Profire L, Tuchilus C.

Chem Cent J. 2016 Feb 4;10:6. doi: 10.1186/s13065-016-0151-6. eCollection 2016.


Design of α7 nicotinic acetylcholine receptor ligands using the (het)Aryl-1,2,3-triazole core: Synthesis, in vitro evaluation and SAR studies.

Ouach A, Pin F, Bertrand E, Vercouillie J, Gulhan Z, Mothes C, Deloye JB, Guilloteau D, Suzenet F, Chalon S, Routier S.

Eur J Med Chem. 2016 Jan 1;107:153-64. doi: 10.1016/j.ejmech.2015.11.001. Epub 2015 Nov 10.


Assessment of the Protection of Dopaminergic Neurons by an α7 Nicotinic Receptor Agonist, PHA 543613 Using [(18)F]LBT-999 in a Parkinson's Disease Rat Model.

Sérrière S, Doméné A, Vercouillie J, Mothes C, Bodard S, Rodrigues N, Guilloteau D, Routier S, Page G, Chalon S.

Front Med (Lausanne). 2015 Sep 2;2:61. doi: 10.3389/fmed.2015.00061. eCollection 2015.

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