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Items: 1 to 20 of 21


Heterozygous Variants in the Mechanosensitive Ion Channel TMEM63A Result in Transient Hypomyelination during Infancy.

Yan H, Helman G, Murthy SE, Ji H, Crawford J, Kubisiak T, Bent SJ, Xiao J, Taft RJ, Coombs A, Wu Y, Pop A, Li D, de Vries LS, Jiang Y, Salomons GS, van der Knaap MS, Patapoutian A, Simons C, Burmeister M, Wang J, Wolf NI.

Am J Hum Genet. 2019 Nov 7;105(5):996-1004. doi: 10.1016/j.ajhg.2019.09.011. Epub 2019 Oct 3.


The Mechanosensitive Ion Channel Piezo Inhibits Axon Regeneration.

Song Y, Li D, Farrelly O, Miles L, Li F, Kim SE, Lo TY, Wang F, Li T, Thompson-Peer KL, Gong J, Murthy SE, Coste B, Yakubovich N, Patapoutian A, Xiang Y, Rompolas P, Jan LY, Jan YN.

Neuron. 2019 Apr 17;102(2):373-389.e6. doi: 10.1016/j.neuron.2019.01.050. Epub 2019 Feb 25.


Cryo-EM structure of the mechanically activated ion channel OSCA1.2.

Jojoa-Cruz S, Saotome K, Murthy SE, Tsui CCA, Sansom MS, Patapoutian A, Ward AB.

Elife. 2018 Nov 1;7. pii: e41845. doi: 10.7554/eLife.41845.


OSCA/TMEM63 are an Evolutionarily Conserved Family of Mechanically Activated Ion Channels.

Murthy SE, Dubin AE, Whitwam T, Jojoa-Cruz S, Cahalan SM, Mousavi SAR, Ward AB, Patapoutian A.

Elife. 2018 Nov 1;7. pii: e41844. doi: 10.7554/eLife.41844.


The mechanosensitive ion channel Piezo2 mediates sensitivity to mechanical pain in mice.

Murthy SE, Loud MC, Daou I, Marshall KL, Schwaller F, Kühnemund J, Francisco AG, Keenan WT, Dubin AE, Lewin GR, Patapoutian A.

Sci Transl Med. 2018 Oct 10;10(462). pii: eaat9897. doi: 10.1126/scitranslmed.aat9897.


Common PIEZO1 Allele in African Populations Causes RBC Dehydration and Attenuates Plasmodium Infection.

Ma S, Cahalan S, LaMonte G, Grubaugh ND, Zeng W, Murthy SE, Paytas E, Gamini R, Lukacs V, Whitwam T, Loud M, Lohia R, Berry L, Khan SM, Janse CJ, Bandell M, Schmedt C, Wengelnik K, Su AI, Honore E, Winzeler EA, Andersen KG, Patapoutian A.

Cell. 2018 Apr 5;173(2):443-455.e12. doi: 10.1016/j.cell.2018.02.047. Epub 2018 Mar 22.


Structure of the mechanically activated ion channel Piezo1.

Saotome K, Murthy SE, Kefauver JM, Whitwam T, Patapoutian A, Ward AB.

Nature. 2018 Feb 22;554(7693):481-486. doi: 10.1038/nature25453. Epub 2017 Dec 20.


Piezos thrive under pressure: mechanically activated ion channels in health and disease.

Murthy SE, Dubin AE, Patapoutian A.

Nat Rev Mol Cell Biol. 2017 Dec;18(12):771-783. doi: 10.1038/nrm.2017.92. Epub 2017 Oct 4. Review.


Endogenous Piezo1 Can Confound Mechanically Activated Channel Identification and Characterization.

Dubin AE, Murthy S, Lewis AH, Brosse L, Cahalan SM, Grandl J, Coste B, Patapoutian A.

Neuron. 2017 Apr 19;94(2):266-270.e3. doi: 10.1016/j.neuron.2017.03.039.


Editorial Note to: Endogenous Piezo1 Can Confound Mechanically Activated Channel Identification and Characterization.

Dubin AE, Murthy S, Lewis AH, Brosse L, Cahalan SM, Grandl J, Coste B, Patapoutian A.

Neuron. 2017 Apr 19;94(2):265. doi: 10.1016/j.neuron.2017.03.041. No abstract available.


Quercetin exhibits adjuvant activity by enhancing Th2 immune response in ovalbumin immunized mice.

Singh D, Tanwar H, Jayashankar B, Sharma J, Murthy S, Chanda S, Singh SB, Ganju L.

Biomed Pharmacother. 2017 Jun;90:354-360. doi: 10.1016/j.biopha.2017.03.067. Epub 2017 Apr 2.


Augmentation of humoral and cellular immunity in response to Tetanus and Diphtheria toxoids by supercritical carbon dioxide extracts of Hippophae rhamnoides L. leaves.

Jayashankar B, Singh D, Tanwar H, Mishra KP, Murthy S, Chanda S, Mishra J, Tulswani R, Misra K, Singh SB, Ganju L.

Int Immunopharmacol. 2017 Mar;44:123-136. doi: 10.1016/j.intimp.2017.01.012. Epub 2017 Jan 13.


LRRC8 Proteins Form Volume-Regulated Anion Channels that Sense Ionic Strength.

Syeda R, Qiu Z, Dubin AE, Murthy SE, Florendo MN, Mason DE, Mathur J, Cahalan SM, Peters EC, Montal M, Patapoutian A.

Cell. 2016 Jan 28;164(3):499-511. doi: 10.1016/j.cell.2015.12.031.


Piezo1 ion channel pore properties are dictated by C-terminal region.

Coste B, Murthy SE, Mathur J, Schmidt M, Mechioukhi Y, Delmas P, Patapoutian A.

Nat Commun. 2015 May 26;6:7223. doi: 10.1038/ncomms8223.


One-channel cell-attached patch-clamp recording.

Maki BA, Cummings KA, Paganelli MA, Murthy SE, Popescu GK.

J Vis Exp. 2014 Jun 9;(88). doi: 10.3791/51629.


Piezo1, a mechanically activated ion channel, is required for vascular development in mice.

Ranade SS, Qiu Z, Woo SH, Hur SS, Murthy SE, Cahalan SM, Xu J, Mathur J, Bandell M, Coste B, Li YS, Chien S, Patapoutian A.

Proc Natl Acad Sci U S A. 2014 Jul 15;111(28):10347-52. doi: 10.1073/pnas.1409233111. Epub 2014 Jun 23.


Dehydrated hereditary stomatocytosis linked to gain-of-function mutations in mechanically activated PIEZO1 ion channels.

Albuisson J, Murthy SE, Bandell M, Coste B, Louis-Dit-Picard H, Mathur J, Fénéant-Thibault M, Tertian G, de Jaureguiberry JP, Syfuss PY, Cahalan S, Garçon L, Toutain F, Simon Rohrlich P, Delaunay J, Picard V, Jeunemaitre X, Patapoutian A.

Nat Commun. 2013;4:1884. doi: 10.1038/ncomms2899. Erratum in: Nat Commun. 2013;4:2440.


Probing the activation sequence of NMDA receptors with lurcher mutations.

Murthy SE, Shogan T, Page JC, Kasperek EM, Popescu GK.

J Gen Physiol. 2012 Sep;140(3):267-77. doi: 10.1085/jgp.201210786. Epub 2012 Aug 13.


The loss of an electrostatic contact unique to AMPA receptor ligand binding domain 2 slows channel activation.

Holley SM, Ahmed AH, Srinivasan J, Murthy SE, Weiland GA, Oswald RE, Nowak LM.

Biochemistry. 2012 May 15;51(19):4015-27. doi: 10.1021/bi3001837. Epub 2012 May 2.


NMDA receptor activation requires remodelling of intersubunit contacts within ligand-binding heterodimers.

Borschel WF, Murthy SE, Kasperek EM, Popescu GK.

Nat Commun. 2011 Oct 11;2:498. doi: 10.1038/ncomms1512.

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