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The Cardiovascular Effects of Noise.

Hahad O, Kröller-Schön S, Daiber A, Münzel T.

Dtsch Arztebl Int. 2019 Apr 5;116(14):245-250. doi: 10.3238/arztebl.2019.0245.


Environmental noise induces the release of stress hormones and inflammatory signaling molecules leading to oxidative stress and vascular dysfunction-Signatures of the internal exposome.

Daiber A, Kröller-Schön S, Frenis K, Oelze M, Kalinovic S, Vujacic-Mirski K, Kuntic M, Bayo Jimenez MT, Helmstädter J, Steven S, Korac B, Münzel T.

Biofactors. 2019 Apr 2. doi: 10.1002/biof.1506. [Epub ahead of print] Review.


The Endothelin Receptor Antagonist Macitentan Improves Isosorbide-5-Mononitrate (ISMN) and Isosorbide Dinitrate (ISDN) Induced Endothelial Dysfunction, Oxidative Stress, and Vascular Inflammation.

Steven S, Oelze M, Hausding M, Roohani S, Kashani F, Kröller-Schön S, Helmstädter J, Jansen T, Baum C, Iglarz M, Schulz E, Münzel T, Daiber A.

Oxid Med Cell Longev. 2018 Dec 27;2018:7845629. doi: 10.1155/2018/7845629. eCollection 2018.


Endothelial α1AMPK modulates angiotensin II-mediated vascular inflammation and dysfunction.

Kröller-Schön S, Jansen T, Tran TLP, Kvandová M, Kalinovic S, Oelze M, Keaney JF Jr, Foretz M, Viollet B, Daiber A, Kossmann S, Lagrange J, Frenis K, Wenzel P, Münzel T, Schulz E.

Basic Res Cardiol. 2019 Jan 14;114(2):8. doi: 10.1007/s00395-019-0717-2.


New Therapeutic Implications of Endothelial Nitric Oxide Synthase (eNOS) Function/Dysfunction in Cardiovascular Disease.

Daiber A, Xia N, Steven S, Oelze M, Hanf A, Kröller-Schön S, Münzel T, Li H.

Int J Mol Sci. 2019 Jan 7;20(1). pii: E187. doi: 10.3390/ijms20010187. Review.


α1AMPK deletion in myelomonocytic cells induces a pro-inflammatory phenotype and enhances angiotensin II-induced vascular dysfunction.

Jansen T, Kröller-Schön S, Schönfelder T, Foretz M, Viollet B, Daiber A, Oelze M, Brandt M, Steven S, Kvandová M, Kalinovic S, Lagrange J, Keaney JF Jr, Münzel T, Wenzel P, Schulz E.

Cardiovasc Res. 2018 Dec 1;114(14):1883-1893. doi: 10.1093/cvr/cvy172.


Crucial role for Nox2 and sleep deprivation in aircraft noise-induced vascular and cerebral oxidative stress, inflammation, and gene regulation.

Kröller-Schön S, Daiber A, Steven S, Oelze M, Frenis K, Kalinovic S, Heimann A, Schmidt FP, Pinto A, Kvandova M, Vujacic-Mirski K, Filippou K, Dudek M, Bosmann M, Klein M, Bopp T, Hahad O, Wild PS, Frauenknecht K, Methner A, Schmidt ER, Rapp S, Mollnau H, Münzel T.

Eur Heart J. 2018 Oct 7;39(38):3528-3539. doi: 10.1093/eurheartj/ehy333.


Modulation of Vascular Function by AMPK: Assessment of NO Bioavailability and Surrogates of Oxidative Stress.

Kröller-Schön S, Daiber A, Schulz E.

Methods Mol Biol. 2018;1732:495-506. doi: 10.1007/978-1-4939-7598-3_31.


The Adverse Effects of Environmental Noise Exposure on Oxidative Stress and Cardiovascular Risk.

Münzel T, Sørensen M, Schmidt F, Schmidt E, Steven S, Kröller-Schön S, Daiber A.

Antioxid Redox Signal. 2018 Mar 20;28(9):873-908. doi: 10.1089/ars.2017.7118. Review.


CD40L controls obesity-associated vascular inflammation, oxidative stress, and endothelial dysfunction in high fat diet-treated and db/db mice.

Steven S, Dib M, Hausding M, Kashani F, Oelze M, Kröller-Schön S, Hanf A, Daub S, Roohani S, Gramlich Y, Lutgens E, Schulz E, Becker C, Lackner KJ, Kleinert H, Knosalla C, Niesler B, Wild PS, Münzel T, Daiber A.

Cardiovasc Res. 2018 Feb 1;114(2):312-323. doi: 10.1093/cvr/cvx197.


Basic in vitro Characterization of the Vasodilatory Potential of 2-Aminoethyl Nitrate Fixed-Dose Combinations with Cilostazol, Metoprolol and Valsartan.

Oelze M, Welschof P, Knorr M, Tran LP, Ullmann E, Stamm P, Kröller-Schön S, Jansen T, Kopp M, Schulz E, Gori T, Burgin K, Scherhag A, Sartor D, Münzel T, Daiber A.

Pharmacology. 2018;101(1-2):54-63. doi: 10.1159/000480434. Epub 2017 Oct 7.


The SGLT2 inhibitor empagliflozin improves the primary diabetic complications in ZDF rats.

Steven S, Oelze M, Hanf A, Kröller-Schön S, Kashani F, Roohani S, Welschof P, Kopp M, Gödtel-Armbrust U, Xia N, Li H, Schulz E, Lackner KJ, Wojnowski L, Bottari SP, Wenzel P, Mayoux E, Münzel T, Daiber A.

Redox Biol. 2017 Oct;13:370-385. doi: 10.1016/j.redox.2017.06.009. Epub 2017 Jun 22.


Pentaerythritol Tetranitrate In Vivo Treatment Improves Oxidative Stress and Vascular Dysfunction by Suppression of Endothelin-1 Signaling in Monocrotaline-Induced Pulmonary Hypertension.

Steven S, Oelze M, Brandt M, Ullmann E, Kröller-Schön S, Heeren T, Tran LP, Daub S, Dib M, Stalleicken D, Wenzel P, Münzel T, Daiber A.

Oxid Med Cell Longev. 2017;2017:4353462. doi: 10.1155/2017/4353462. Epub 2017 Feb 28.


Effects of noise on vascular function, oxidative stress, and inflammation: mechanistic insight from studies in mice.

Münzel T, Daiber A, Steven S, Tran LP, Ullmann E, Kossmann S, Schmidt FP, Oelze M, Xia N, Li H, Pinto A, Wild P, Pies K, Schmidt ER, Rapp S, Kröller-Schön S.

Eur Heart J. 2017 Oct 1;38(37):2838-2849. doi: 10.1093/eurheartj/ehx081.


Taking up the cudgels for the traditional reactive oxygen and nitrogen species detection assays and their use in the cardiovascular system.

Daiber A, Oelze M, Steven S, Kröller-Schön S, Münzel T.

Redox Biol. 2017 Aug;12:35-49. doi: 10.1016/j.redox.2017.02.001. Epub 2017 Feb 7. Review.


PGC-1α dictates endothelial function through regulation of eNOS expression.

Craige SM, Kröller-Schön S, Li C, Kant S, Cai S, Chen K, Contractor MM, Pei Y, Schulz E, Keaney JF Jr.

Sci Rep. 2016 Dec 2;6:38210. doi: 10.1038/srep38210.


NOX2 amplifies acetaldehyde-mediated cardiomyocyte mitochondrial dysfunction in alcoholic cardiomyopathy.

Brandt M, Garlapati V, Oelze M, Sotiriou E, Knorr M, Kröller-Schön S, Kossmann S, Schönfelder T, Morawietz H, Schulz E, Schultheiss HP, Daiber A, Münzel T, Wenzel P.

Sci Rep. 2016 Sep 14;6:32554. doi: 10.1038/srep32554.


Glucagon-like peptide-1 receptor signalling reduces microvascular thrombosis, nitro-oxidative stress and platelet activation in endotoxaemic mice.

Steven S, Jurk K, Kopp M, Kröller-Schön S, Mikhed Y, Schwierczek K, Roohani S, Kashani F, Oelze M, Klein T, Tokalov S, Danckwardt S, Strand S, Wenzel P, Münzel T, Daiber A.

Br J Pharmacol. 2017 Jun;174(12):1620-1632. doi: 10.1111/bph.13549. Epub 2016 Aug 21.


Nitroglycerin induces DNA damage and vascular cell death in the setting of nitrate tolerance.

Mikhed Y, Fahrer J, Oelze M, Kröller-Schön S, Steven S, Welschof P, Zinßius E, Stamm P, Kashani F, Roohani S, Kress JM, Ullmann E, Tran LP, Schulz E, Epe B, Kaina B, Münzel T, Daiber A.

Basic Res Cardiol. 2016 Jul;111(4):52. doi: 10.1007/s00395-016-0571-4. Epub 2016 Jun 29.


Crosstalk of mitochondria with NADPH oxidase via reactive oxygen and nitrogen species signalling and its role for vascular function.

Daiber A, Di Lisa F, Oelze M, Kröller-Schön S, Steven S, Schulz E, Münzel T.

Br J Pharmacol. 2017 Jun;174(12):1670-1689. doi: 10.1111/bph.13403. Epub 2016 Feb 4. Review.

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