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Items: 1 to 20 of 25

1.

The APOE3-Leiden Heterozygous Glucokinase Knockout Mouse as Novel Translational Disease Model for Type 2 Diabetes, Dyslipidemia, and Diabetic Atherosclerosis.

Pouwer MG, Heinonen SE, Behrendt M, Andréasson AC, van Koppen A, Menke AL, Pieterman EJ, van den Hoek AM, Jukema JW, Leighton B, Jönsson-Rylander AC, Princen HMG.

J Diabetes Res. 2019 Feb 21;2019:9727952. doi: 10.1155/2019/9727952. eCollection 2019.

2.

Hyperglycemia does not affect tissue repair responses in shear stress-induced atherosclerotic plaques in ApoE-/- mice.

Hsiung S, Knutsson A, Vallejo J, Dunér P, Heinonen SE, Jönsson-Rylander AC, Bengtsson E, Nilsson J, Hultgårdh-Nilsson A.

Sci Rep. 2018 May 14;8(1):7530. doi: 10.1038/s41598-018-25942-3.

3.

A Genome-Wide Association Study of Diabetic Kidney Disease in Subjects With Type 2 Diabetes.

van Zuydam NR, Ahlqvist E, Sandholm N, Deshmukh H, Rayner NW, Abdalla M, Ladenvall C, Ziemek D, Fauman E, Robertson NR, McKeigue PM, Valo E, Forsblom C, Harjutsalo V; Finnish Diabetic Nephropathy Study (FinnDiane), Perna A, Rurali E, Marcovecchio ML, Igo RP Jr, Salem RM, Perico N, Lajer M, Käräjämäki A, Imamura M, Kubo M, Takahashi A, Sim X, Liu J, van Dam RM, Jiang G, Tam CHT, Luk AOY, Lee HM, Lim CKP, Szeto CC, So WY, Chan JCN; Hong Kong Diabetes Registry Theme-based Research Scheme Project Group, Ang SF, Dorajoo R, Wang L, Clara TSH, McKnight AJ, Duffy S; Warren 3 and Genetics of Kidneys in Diabetes (GoKinD) Study Group, Pezzolesi MG; GENIE (GEnetics of Nephropathy an International Effort) Consortium, Marre M, Gyorgy B, Hadjadj S, Hiraki LT; Diabetes Control and Complications Trial (DCCT)/Epidemiology of Diabetes Interventions and Complications (EDIC) Research Group, Ahluwalia TS, Almgren P, Schulz CA, Orho-Melander M, Linneberg A, Christensen C, Witte DR, Grarup N, Brandslund I, Melander O, Paterson AD, Tregouet D, Maxwell AP, Lim SC, Ma RCW, Tai ES, Maeda S, Lyssenko V, Tuomi T, Krolewski AS, Rich SS, Hirschhorn JN, Florez JC, Dunger D, Pedersen O, Hansen T, Rossing P, Remuzzi G; SUrrogate markers for Micro- and Macrovascular hard endpoints for Innovative diabetes Tools (SUMMIT) Consortium, Brosnan MJ, Palmer CNA, Groop PH, Colhoun HM, Groop LC, McCarthy MI.

Diabetes. 2018 Jul;67(7):1414-1427. doi: 10.2337/db17-0914. Epub 2018 Apr 27.

4.

In vivo inhibition of nuclear factor of activated T-cells leads to atherosclerotic plaque regression in IGF-II/LDLR-/-ApoB100/100 mice.

Blanco F, Heinonen SE, Gurzeler E, Berglund LM, Dutius Andersson AM, Kotova O, Jönsson-Rylander AC, Ylä-Herttuala S, Gomez MF.

Diab Vasc Dis Res. 2018 Jul;15(4):302-313. doi: 10.1177/1479164118759220. Epub 2018 Mar 2.

5.

Hyperglycemia Induced by Glucokinase Deficiency Accelerates Atherosclerosis Development and Impairs Lesion Regression in Combined Heterozygous Glucokinase and the Apolipoprotein E-Knockout Mice.

Adingupu DD, Heinonen SE, Andréasson AC, Brusberg M, Ahnmark A, Behrendt M, Leighton B, Jönsson-Rylander AC.

J Diabetes Res. 2016;2016:8630961. Epub 2016 Sep 28.

6.

Impaired Coronary and Renal Vascular Function in Spontaneously Type 2 Diabetic Leptin-Deficient Mice.

Westergren HU, Grönros J, Heinonen SE, Miliotis T, Jennbacken K, Sabirsh A, Ericsson A, Jönsson-Rylander AC, Svedlund S, Gan LM.

PLoS One. 2015 Jun 22;10(6):e0130648. doi: 10.1371/journal.pone.0130648. eCollection 2015.

7.

Animal models of diabetic macrovascular complications: key players in the development of new therapeutic approaches.

Heinonen SE, Genové G, Bengtsson E, Hübschle T, Åkesson L, Hiss K, Benardeau A, Ylä-Herttuala S, Jönsson-Rylander AC, Gomez MF.

J Diabetes Res. 2015;2015:404085. doi: 10.1155/2015/404085. Epub 2015 Feb 15. Review.

8.

[18F]fluorodeoxyglucose uptake in atherosclerotic plaques is associated with reduced coronary flow reserve in mice.

Uotila S, Silvola JM, Saukko P, Nuutila P, Heinonen SE, Ylä-Herttuala S, Roivainen A, Knuuti J, Saraste A.

J Ultrasound Med. 2014 Nov;33(11):1941-8. doi: 10.7863/ultra.33.11.1941.

PMID:
25336481
9.

Lymphatic vessel insufficiency in hypercholesterolemic mice alters lipoprotein levels and promotes atherogenesis.

Vuorio T, Nurmi H, Moulton K, Kurkipuro J, Robciuc MR, Ohman M, Heinonen SE, Samaranayake H, Heikura T, Alitalo K, Ylä-Herttuala S.

Arterioscler Thromb Vasc Biol. 2014 Jun;34(6):1162-70. doi: 10.1161/ATVBAHA.114.302528. Epub 2014 Apr 10.

10.

LDLR-/-ApoB100/100 mice with insulin-like growth factor II overexpression reveal a novel form of retinopathy with photoreceptor atrophy and altered morphology of the retina.

Kinnunen K, Heinonen SE, Kalesnykas G, Laidinen S, Uusitalo-Järvinen H, Uusitalo H, Ylä-Herttuala S.

Mol Vis. 2013 Aug 4;19:1723-33. Print 2013.

11.

The effects of VEGF-A on atherosclerosis, lipoprotein profile, and lipoprotein lipase in hyperlipidaemic mouse models.

Heinonen SE, Kivelä AM, Huusko J, Dijkstra MH, Gurzeler E, Mäkinen PI, Leppänen P, Olkkonen VM, Eriksson U, Jauhiainen M, Ylä-Herttuala S.

Cardiovasc Res. 2013 Sep 1;99(4):716-23. doi: 10.1093/cvr/cvt148. Epub 2013 Jun 10.

PMID:
23756254
12.

The absence of macrophage Nrf2 promotes early atherogenesis.

Ruotsalainen AK, Inkala M, Partanen ME, Lappalainen JP, Kansanen E, Mäkinen PI, Heinonen SE, Laitinen HM, Heikkilä J, Vatanen T, Hörkkö S, Yamamoto M, Ylä-Herttuala S, Jauhiainen M, Levonen AL.

Cardiovasc Res. 2013 Apr 1;98(1):107-15. doi: 10.1093/cvr/cvt008. Epub 2013 Jan 22.

PMID:
23341579
13.

Regulation of endothelial lipase and systemic HDL cholesterol levels by SREBPs and VEGF-A.

Kivelä AM, Dijkstra MH, Heinonen SE, Gurzeler E, Jauhiainen S, Levonen AL, Ylä-Herttuala S.

Atherosclerosis. 2012 Dec;225(2):335-40. doi: 10.1016/j.atherosclerosis.2012.09.039. Epub 2012 Oct 9.

PMID:
23102786
14.

Endothelium-specific overexpression of human vascular endothelial growth factor-D in mice leads to increased tumor frequency and a reduced lifespan.

Kotimaa AA, Zainana AM, Pulkkinen E, Huusko J, Heinonen SE, Kholová I, Stedt H, Lesch HP, Ylä-Herttuala S.

J Gene Med. 2012 Mar;14(3):182-90. doi: 10.1002/jgm.2608.

PMID:
22287362
15.

Effects of age, diet, and type 2 diabetes on the development and FDG uptake of atherosclerotic plaques.

Silvola JM, Saraste A, Laitinen I, Savisto N, Laine VJ, Heinonen SE, Ylä-Herttuala S, Saukko P, Nuutila P, Roivainen A, Knuuti J.

JACC Cardiovasc Imaging. 2011 Dec;4(12):1294-301. doi: 10.1016/j.jcmg.2011.07.009.

16.

Left ventricular dysfunction with reduced functional cardiac reserve in diabetic and non-diabetic LDL-receptor deficient apolipoprotein B100-only mice.

Heinonen SE, Merentie M, Hedman M, Mäkinen PI, Loponen E, Kholová I, Bosch F, Laakso M, Ylä-Herttuala S.

Cardiovasc Diabetol. 2011 Jun 30;10:59. doi: 10.1186/1475-2840-10-59.

17.

Vascular endothelial growth factor (VEGF)-D stimulates VEGF-A, stanniocalcin-1, and neuropilin-2 and has potent angiogenic effects.

Jauhiainen S, Häkkinen SK, Toivanen PI, Heinonen SE, Jyrkkänen HK, Kansanen E, Leinonen H, Levonen AL, Ylä-Herttuala S.

Arterioscler Thromb Vasc Biol. 2011 Jul;31(7):1617-24. doi: 10.1161/ATVBAHA.111.225961. Epub 2011 Apr 7.

PMID:
21474827
18.

Detection of hypoxia by [18F]EF5 in atherosclerotic plaques in mice.

Silvola JM, Saraste A, Forsback S, Laine VJ, Saukko P, Heinonen SE, Ylä-Herttuala S, Roivainen A, Knuuti J.

Arterioscler Thromb Vasc Biol. 2011 May;31(5):1011-5. doi: 10.1161/ATVBAHA.110.221440. Epub 2011 Mar 3.

PMID:
21372297
19.

Silencing of either SR-A or CD36 reduces atherosclerosis in hyperlipidaemic mice and reveals reciprocal upregulation of these receptors.

Mäkinen PI, Lappalainen JP, Heinonen SE, Leppänen P, Lähteenvuo MT, Aarnio JV, Heikkilä J, Turunen MP, Ylä-Herttuala S.

Cardiovasc Res. 2010 Dec 1;88(3):530-8. doi: 10.1093/cvr/cvq235. Epub 2010 Jul 15.

PMID:
20634212
20.

The effects of VEGF-R1 and VEGF-R2 ligands on angiogenic responses and left ventricular function in mice.

Huusko J, Merentie M, Dijkstra MH, Ryhänen MM, Karvinen H, Rissanen TT, Vanwildemeersch M, Hedman M, Lipponen J, Heinonen SE, Eriksson U, Shibuya M, Ylä-Herttuala S.

Cardiovasc Res. 2010 Apr 1;86(1):122-30. doi: 10.1093/cvr/cvp382. Epub 2009 Dec 2.

PMID:
19955220

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