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Items: 1 to 20 of 26


Vitamin D and Phenylbutyrate Supplementation Does Not Modulate Gut Derived Immune Activation in HIV-1.

Missailidis C, Sørensen N, Ashenafi S, Amogne W, Kassa E, Bekele A, Getachew M, Gebreselassie N, Aseffa A, Aderaye G, Andersson J, Brighenti S, Bergman P.

Nutrients. 2019 Jul 21;11(7). pii: E1675. doi: 10.3390/nu11071675.


Daily Nutritional Supplementation with Vitamin D₃ and Phenylbutyrate to Treatment-Naïve HIV Patients Tested in a Randomized Placebo-Controlled Trial.

Ashenafi S, Amogne W, Kassa E, Gebreselassie N, Bekele A, Aseffa G, Getachew M, Aseffa A, Worku A, Hammar U, Bergman P, Aderaye G, Andersson J, Brighenti S.

Nutrients. 2019 Jan 10;11(1). pii: E133. doi: 10.3390/nu11010133.


Vitamin D₃ Status and the Association with Human Cathelicidin Expression in Patients with Different Clinical Forms of Active Tuberculosis.

Ashenafi S, Mazurek J, Rehn A, Lemma B, Aderaye G, Bekele A, Assefa G, Chanyalew M, Aseffa A, Andersson J, Bergman P, Brighenti S.

Nutrients. 2018 Jun 4;10(6). pii: E721. doi: 10.3390/nu10060721.


Prostaglandin E2 suppresses hCAP18/LL-37 expression in human macrophages via EP2/EP4: implications for treatment of Mycobacterium tuberculosis infection.

Wan M, Tang X, Rekha RS, Muvva SSVJR, Brighenti S, Agerberth B, Haeggström JZ.

FASEB J. 2018 May;32(5):2827-2840. doi: 10.1096/fj.201701308. Epub 2018 Jan 17.


Inhibition of Tissue Matrix Metalloproteinases Interferes with Mycobacterium tuberculosis-Induced Granuloma Formation and Reduces Bacterial Load in a Human Lung Tissue Model.

Parasa VR, Muvva JR, Rose JF, Braian C, Brighenti S, Lerm M.

Front Microbiol. 2017 Dec 5;8:2370. doi: 10.3389/fmicb.2017.02370. eCollection 2017.



Bekele A, Ashenafi S, Aderay G, Assefa G, Aseffa A, Anderssen J, Brighenti S.

Ethiop Med J. 2016 Oct;54(4):181-8.


Enhanced CD8+ cytolytic T cell responses in the peripheral circulation of patients with sarcoidosis and non-Löfgren's disease.

Parasa VR, Forsslund H, Enger T, Lorenz D, Kullberg S, Eklund A, Sköld M, Wahlström J, Grunewald J, Brighenti S.

Respir Med. 2018 May;138S:S38-S44. doi: 10.1016/j.rmed.2017.10.006. Epub 2017 Oct 13.


IL-7δ5 protein is expressed in human tissues and induces expression of the oxidized low density lipoprotein receptor 1 (OLR1) in CD14+ monocytes.

Rane L, Rahman S, Magalhaes I, Ambati A, Andersson J, Zumla A, Brighenti S, Maeurer MJ.

Int J Infect Dis. 2017 Jun;59:29-36. doi: 10.1016/j.ijid.2017.03.001. Epub 2017 Mar 6.


Safety and immunogenicity of the novel H4:IC31 tuberculosis vaccine candidate in BCG-vaccinated adults: Two phase I dose escalation trials.

Norrby M, Vesikari T, Lindqvist L, Maeurer M, Ahmed R, Mahdavifar S, Bennett S, McClain JB, Shepherd BM, Li D, Hokey DA, Kromann I, Hoff ST, Andersen P, de Visser AW, Joosten SA, Ottenhoff THM, Andersson J, Brighenti S.

Vaccine. 2017 Mar 14;35(12):1652-1661. doi: 10.1016/j.vaccine.2017.01.055. Epub 2017 Feb 17.


Peptide microarray-based characterization of antibody responses to host proteins after bacille Calmette-Guérin vaccination.

Valentini D, Rao M, Rane L, Rahman S, Axelsson-Robertson R, Heuchel R, Löhr M, Hoft D, Brighenti S, Zumla A, Maeurer M.

Int J Infect Dis. 2017 Mar;56:140-154. doi: 10.1016/j.ijid.2017.01.027. Epub 2017 Feb 2.


Humoral immune profiling of mycobacterial antigen recognition in sarcoidosis and Löfgren's syndrome using high-content peptide microarrays.

Ferrara G, Valentini D, Rao M, Wahlström J, Grunewald J, Larsson LO, Brighenti S, Dodoo E, Zumla A, Maeurer M.

Int J Infect Dis. 2017 Mar;56:167-175. doi: 10.1016/j.ijid.2017.01.021. Epub 2017 Jan 31.


Regulation of Immunity to Tuberculosis.

Brighenti S, Ordway DJ.

Microbiol Spectr. 2016 Dec;4(6). doi: 10.1128/microbiolspec.TBTB2-0006-2016. Review.


A 3D Human Lung Tissue Model for Functional Studies on Mycobacterium tuberculosis Infection.

Braian C, Svensson M, Brighenti S, Lerm M, Parasa VR.

J Vis Exp. 2015 Oct 5;(104). doi: 10.3791/53084.


B in TB: B Cells as Mediators of Clinically Relevant Immune Responses in Tuberculosis.

Rao M, Valentini D, Poiret T, Dodoo E, Parida S, Zumla A, Brighenti S, Maeurer M.

Clin Infect Dis. 2015 Oct 15;61Suppl 3:S225-34. doi: 10.1093/cid/civ614. Review.


Significant Effects of Oral Phenylbutyrate and Vitamin D3 Adjunctive Therapy in Pulmonary Tuberculosis: A Randomized Controlled Trial.

Mily A, Rekha RS, Kamal SM, Arifuzzaman AS, Rahim Z, Khan L, Haq MA, Zaman K, Bergman P, Brighenti S, Gudmundsson GH, Agerberth B, Raqib R.

PLoS One. 2015 Sep 22;10(9):e0138340. doi: 10.1371/journal.pone.0138340. eCollection 2015.


Phenylbutyrate induces LL-37-dependent autophagy and intracellular killing of Mycobacterium tuberculosis in human macrophages.

Rekha RS, Rao Muvva SS, Wan M, Raqib R, Bergman P, Brighenti S, Gudmundsson GH, Agerberth B.

Autophagy. 2015;11(9):1688-99. doi: 10.1080/15548627.2015.1075110.


Pulmonary tuberculosis patients with a vitamin D deficiency demonstrate low local expression of the antimicrobial peptide LL-37 but enhanced FoxP3+ regulatory T cells and IgG-secreting cells.

Rahman S, Rehn A, Rahman J, Andersson J, Svensson M, Brighenti S.

Clin Immunol. 2015 Feb;156(2):85-97. doi: 10.1016/j.clim.2014.12.003. Epub 2014 Dec 12.


Progression of clinical tuberculosis is associated with a Th2 immune response signature in combination with elevated levels of SOCS3.

Ashenafi S, Aderaye G, Bekele A, Zewdie M, Aseffa G, Hoang AT, Carow B, Habtamu M, Wijkander M, Rottenberg M, Aseffa A, Andersson J, Svensson M, Brighenti S.

Clin Immunol. 2014 Apr;151(2):84-99. doi: 10.1016/j.clim.2014.01.010. Epub 2014 Feb 9.


Modeling Mycobacterium tuberculosis early granuloma formation in experimental human lung tissue.

Parasa VR, Rahman MJ, Ngyuen Hoang AT, Svensson M, Brighenti S, Lerm M.

Dis Model Mech. 2014 Feb;7(2):281-8. doi: 10.1242/dmm.013854. Epub 2013 Nov 7.


BCG-specific IgG-secreting peripheral plasmablasts as a potential biomarker of active tuberculosis in HIV negative and HIV positive patients.

Ashenafi S, Aderaye G, Zewdie M, Raqib R, Bekele A, Magalhaes I, Lema B, Habtamu M, Rekha RS, Aseffa G, Maeurer M, Aseffa A, Svensson M, Andersson J, Brighenti S.

Thorax. 2013 Mar;68(3):269-76. doi: 10.1136/thoraxjnl-2012-201817. Epub 2012 Aug 24.

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