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Short periods of hypoxia upregulate Sphingosine Kinase 1 and increase vasodilation of arteries to Sphingosine 1-Phosphate via S1P3.

Alganga H, Almabrouk TAM, Katwan OJ, Daly CJ, Pyne S, Pyne NJ, Kennedy S.

J Pharmacol Exp Ther. 2019 Aug 1. pii: jpet.119.257931. doi: 10.1124/jpet.119.257931. [Epub ahead of print]


Ceramide and sphingosine 1-phosphate in adipose dysfunction.

Fang Z, Pyne S, Pyne NJ.

Prog Lipid Res. 2019 Apr;74:145-159. doi: 10.1016/j.plipres.2019.04.001. Epub 2019 Apr 2. Review.


Topographical Mapping of Isoform-Selectivity Determinants for J-Channel-Binding Inhibitors of Sphingosine Kinases 1 and 2.

Adams DR, Tawati S, Berretta G, Rivas PL, Baiget J, Jiang Z, Alsfouk A, Mackay SP, Pyne NJ, Pyne S.

J Med Chem. 2019 Apr 11;62(7):3658-3676. doi: 10.1021/acs.jmedchem.9b00162. Epub 2019 Mar 27.


Requirement for sphingosine kinase 1 in mediating phase 1 of the hypotensive response to anandamide in the anaesthetised mouse.

Greig FH, Nather K, Ballantyne MD, Kazi ZH, Alganga H, Ewart MA, Zaborska KE, Fertig B, Pyne NJ, Pyne S, Kennedy S.

Eur J Pharmacol. 2019 Jan 5;842:1-9. doi: 10.1016/j.ejphar.2018.10.027. Epub 2018 Oct 23.


Does the Sphingosine 1-Phosphate Receptor-1 Provide a Better or Worse Prognostic Outcome for Breast Cancer Patients?

Pyne NJ, Pyne S.

Front Oncol. 2018 Sep 27;8:417. doi: 10.3389/fonc.2018.00417. eCollection 2018. No abstract available.


Native and Polyubiquitinated Forms of Dihydroceramide Desaturase Are Differentially Linked to Human Embryonic Kidney Cell Survival.

Alsanafi M, Kelly SL, Jubair K, McNaughton M, Tate RJ, Merrill AH Jr, Pyne S, Pyne NJ.

Mol Cell Biol. 2018 Nov 13;38(23). pii: e00222-18. doi: 10.1128/MCB.00222-18. Print 2018 Dec 1.


Sphingosine Kinases as Druggable Targets.

Pyne S, Adams DR, Pyne NJ.

Handb Exp Pharmacol. 2018 Feb 20. doi: 10.1007/164_2018_96. [Epub ahead of print]


Sphingosine 1-phosphate and cancer.

Pyne NJ, El Buri A, Adams DR, Pyne S.

Adv Biol Regul. 2018 May;68:97-106. doi: 10.1016/j.jbior.2017.09.006. Epub 2017 Sep 15. Review.


Sphingosine Kinase 1: A Potential Therapeutic Target in Pulmonary Arterial Hypertension?

Pyne NJ, Pyne S.

Trends Mol Med. 2017 Sep;23(9):786-798. doi: 10.1016/j.molmed.2017.07.001. Epub 2017 Aug 5. Review.


Sphingosine Kinase 2 in Autoimmune/Inflammatory Disease and the Development of Sphingosine Kinase 2 Inhibitors.

Pyne NJ, Adams DR, Pyne S.

Trends Pharmacol Sci. 2017 Jul;38(7):581-591. doi: 10.1016/ Epub 2017 Jun 9. Review.


Sphingosine kinase 2 and multiple myeloma.

Pyne NJ, Pyne S.

Oncotarget. 2017 Jul 4;8(27):43596-43597. doi: 10.18632/oncotarget.17420. No abstract available.


Sphingosine 1-Phosphate Receptor 1 Signaling in Mammalian Cells.

Pyne NJ, Pyne S.

Molecules. 2017 Feb 23;22(3). pii: E344. doi: 10.3390/molecules22030344. Review.


Effect of sphingosine kinase modulators on interleukin-1β release, sphingosine 1-phosphate receptor 1 expression and experimental autoimmune encephalomyelitis.

Barbour M, McNaughton M, Boomkamp SD, MacRitchie N, Jiang HR, Pyne NJ, Pyne S.

Br J Pharmacol. 2017 Jan;174(2):210-222. doi: 10.1111/bph.13670. Epub 2016 Dec 20.


Effect of the sphingosine kinase 1 selective inhibitor, PF-543 on arterial and cardiac remodelling in a hypoxic model of pulmonary arterial hypertension.

MacRitchie N, Volpert G, Al Washih M, Watson DG, Futerman AH, Kennedy S, Pyne S, Pyne NJ.

Cell Signal. 2016 Aug;28(8):946-55. doi: 10.1016/j.cellsig.2016.03.014. Epub 2016 Apr 6.


Sphingosine Kinases: Emerging Structure-Function Insights.

Adams DR, Pyne S, Pyne NJ.

Trends Biochem Sci. 2016 May;41(5):395-409. doi: 10.1016/j.tibs.2016.02.007. Epub 2016 Mar 25. Review.


Sphingosine 1-phosphate and sphingosine kinases in health and disease: Recent advances.

Pyne S, Adams DR, Pyne NJ.

Prog Lipid Res. 2016 Apr;62:93-106. doi: 10.1016/j.plipres.2016.03.001. Epub 2016 Mar 10. Review.


Pharmacological Characterization of the αvβ6 Integrin Binding and Internalization Kinetics of the Foot-and-Mouth Disease Virus Derived Peptide A20FMDV2.

Slack RJ, Hafeji M, Rogers R, Ludbrook SB, Marshall JF, Flint DJ, Pyne S, Denyer JC.

Pharmacology. 2016;97(3-4):114-25. doi: 10.1159/000443180. Epub 2016 Jan 7.


Role of sphingosine 1-phosphate receptors, sphingosine kinases and sphingosine in cancer and inflammation.

Pyne NJ, McNaughton M, Boomkamp S, MacRitchie N, Evangelisti C, Martelli AM, Jiang HR, Ubhi S, Pyne S.

Adv Biol Regul. 2016 Jan;60:151-159. doi: 10.1016/j.jbior.2015.09.001. Epub 2015 Sep 25. Review.

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