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Items: 17


Pharmacological Inhibition of Myocardin-related Transcription Factor Pathway Blocks Lung Metastases of RhoC-Overexpressing Melanoma.

Haak AJ, Appleton KM, Lisabeth EM, Misek SA, Ji Y, Wade SM, Bell JL, Rockwell CE, Airik M, Krook MA, Larsen SD, Verhaegen M, Lawlor ER, Neubig RR.

Mol Cancer Ther. 2017 Jan;16(1):193-204. doi: 10.1158/1535-7163.MCT-16-0482. Epub 2016 Nov 11.


Small-Molecule Inhibition of Rho/MKL/SRF Transcription in Prostate Cancer Cells: Modulation of Cell Cycle, ER Stress, and Metastasis Gene Networks.

Evelyn CR, Lisabeth EM, Wade SM, Haak AJ, Johnson CN, Lawlor ER, Neubig RR.

Microarrays (Basel). 2016 May 28;5(2). pii: E13. doi: 10.3390/microarrays5020013.


Selectivity and anti-Parkinson's potential of thiadiazolidinone RGS4 inhibitors.

Blazer LL, Storaska AJ, Jutkiewicz EM, Turner EM, Calcagno M, Wade SM, Wang Q, Huang XP, Traynor JR, Husbands SM, Morari M, Neubig RR.

ACS Chem Neurosci. 2015 Jun 17;6(6):911-9. doi: 10.1021/acschemneuro.5b00063. Epub 2015 Apr 20.


Conditional disruption of interactions between Gαi2 and regulator of G protein signaling (RGS) proteins protects the heart from ischemic injury.

Parra S, Huang X, Charbeneau RA, Wade SM, Kaur K, Rorabaugh BR, Neubig RR.

BMC Pharmacol Toxicol. 2014 Jun 5;15:29. doi: 10.1186/2050-6511-15-29.


How prepared are college freshmen athletes for the rigors of college strength and conditioning? A survey of college strength and conditioning coaches.

Wade SM, Pope ZC, Simonson SR.

J Strength Cond Res. 2014 Oct;28(10):2746-53. doi: 10.1519/JSC.0000000000000473.


Reversible inhibitors of regulators of G-protein signaling identified in a high-throughput cell-based calcium signaling assay.

Storaska AJ, Mei JP, Wu M, Li M, Wade SM, Blazer LL, Sjögren B, Hopkins CR, Lindsley CW, Lin Z, Babcock JJ, McManus OB, Neubig RR.

Cell Signal. 2013 Dec;25(12):2848-55. doi: 10.1016/j.cellsig.2013.09.007. Epub 2013 Sep 14.


Design and synthesis of tag-free photoprobes for the identification of the molecular target for CCG-1423, a novel inhibitor of the Rho/MKL1/SRF signaling pathway.

Bell JL, Haak AJ, Wade SM, Sun Y, Neubig RR, Larsen SD.

Beilstein J Org Chem. 2013 May 21;9:966-73. doi: 10.3762/bjoc.9.111. Print 2013.


Microfluidic interrogation and mathematical modeling of multi-regime calcium signaling dynamics.

Jovic A, Wade SM, Neubig RR, Linderman JJ, Takayama S.

Integr Biol (Camb). 2013 Jul 24;5(7):932-9. doi: 10.1039/c3ib40032h. Epub 2013 Jun 4.


Optimization of novel nipecotic bis(amide) inhibitors of the Rho/MKL1/SRF transcriptional pathway as potential anti-metastasis agents.

Bell JL, Haak AJ, Wade SM, Kirchhoff PD, Neubig RR, Larsen SD.

Bioorg Med Chem Lett. 2013 Jul 1;23(13):3826-32. doi: 10.1016/j.bmcl.2013.04.080. Epub 2013 May 7.


Gαi2 signaling: friend or foe in cardiac injury and heart failure?

Kaur K, Parra S, Chen R, Charbeneau RA, Wade SM, Jay PY, Neubig RR.

Naunyn Schmiedebergs Arch Pharmacol. 2012 May;385(5):443-53. doi: 10.1007/s00210-011-0705-z. Epub 2012 Mar 14.


Hi-Fi transmission of periodic signals amid cell-to-cell variability.

Jovic A, Wade SM, Miyawaki A, Neubig RR, Linderman JJ, Takayama S.

Mol Biosyst. 2011 Jul;7(7):2238-44. doi: 10.1039/c1mb05031a. Epub 2011 May 11.


Phase-locked signals elucidate circuit architecture of an oscillatory pathway.

Jovic A, Howell B, Cote M, Wade SM, Mehta K, Miyawaki A, Neubig RR, Linderman JJ, Takayama S.

PLoS Comput Biol. 2010 Dec 23;6(12):e1001040. doi: 10.1371/journal.pcbi.1001040.


Design, synthesis and prostate cancer cell-based studies of analogs of the Rho/MKL1 transcriptional pathway inhibitor, CCG-1423.

Evelyn CR, Bell JL, Ryu JG, Wade SM, Kocab A, Harzdorf NL, Showalter HD, Neubig RR, Larsen SD.

Bioorg Med Chem Lett. 2010 Jan 15;20(2):665-72. doi: 10.1016/j.bmcl.2009.11.056. Epub 2009 Nov 18.


CCG-1423: a small-molecule inhibitor of RhoA transcriptional signaling.

Evelyn CR, Wade SM, Wang Q, Wu M, Iñiguez-Lluhí JA, Merajver SD, Neubig RR.

Mol Cancer Ther. 2007 Aug;6(8):2249-60.


Capillary electrophoresis assay for G protein-coupled receptor-mediated GTPase activity.

Jameson EE, Pei J, Wade SM, Neubig RR, Milligan G, Kennedy RT.

Anal Chem. 2007 Feb 1;79(3):1158-63.


A spatial focusing model for G protein signals. Regulator of G protein signaling (RGS) protien-mediated kinetic scaffolding.

Zhong H, Wade SM, Woolf PJ, Linderman JJ, Traynor JR, Neubig RR.

J Biol Chem. 2003 Feb 28;278(9):7278-84. Epub 2002 Nov 21.


Mutagenesis and peptide analysis of the DRY motif in the alpha2A adrenergic receptor: evidence for alternate mechanisms in G protein-coupled receptors.

Chung DA, Wade SM, Fowler CB, Woods DD, Abada PB, Mosberg HI, Neubig RR.

Biochem Biophys Res Commun. 2002 May 17;293(4):1233-41.


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