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Items: 1 to 20 of 47


CD38-Driven Mitochondrial Trafficking Promotes Bioenergetic Plasticity in Multiple Myeloma.

Marlein CR, Piddock RE, Mistry JJ, Zaitseva L, Hellmich C, Horton RH, Zhou Z, Auger MJ, Bowles KM, Rushworth SA.

Cancer Res. 2019 May 1;79(9):2285-2297. doi: 10.1158/0008-5472.CAN-18-0773. Epub 2019 Jan 8.


Acute myeloid leukemia induces protumoral p16INK4a-driven senescence in the bone marrow microenvironment.

Abdul-Aziz AM, Sun Y, Hellmich C, Marlein CR, Mistry J, Forde E, Piddock RE, Shafat MS, Morfakis A, Mehta T, Di Palma F, Macaulay I, Ingham CJ, Haestier A, Collins A, Campisi J, Bowles KM, Rushworth SA.

Blood. 2019 Jan 31;133(5):446-456. doi: 10.1182/blood-2018-04-845420. Epub 2018 Nov 6.


Targeting the KEAP1/NRF2 pathway to manipulate the expression of oncogenic and oncosuppressive miRNAs in human leukemia.

Bowles KM, Rushworth SA.

Mol Cell Oncol. 2018 Apr 19;5(3):e988484. doi: 10.4161/23723556.2014.988484. eCollection 2018.


PGC-1α driven mitochondrial biogenesis in stromal cells underpins mitochondrial trafficking to leukemic blasts.

Marlein CR, Zaitseva L, Piddock RE, Raso-Barnett L, Scott MA, Ingham CJ, Collins A, Bowles KM, Rushworth SA.

Leukemia. 2018 Sep;32(9):2073-2077. doi: 10.1038/s41375-018-0221-y. Epub 2018 Jul 20. No abstract available.


Myeloma-derived macrophage inhibitory factor regulates bone marrow stromal cell-derived IL-6 via c-MYC.

Piddock RE, Marlein CR, Abdul-Aziz A, Shafat MS, Auger MJ, Bowles KM, Rushworth SA.

J Hematol Oncol. 2018 May 16;11(1):66. doi: 10.1186/s13045-018-0614-4.


HIF1α drives chemokine factor pro-tumoral signaling pathways in acute myeloid leukemia.

Abdul-Aziz AM, Shafat MS, Sun Y, Marlein CR, Piddock RE, Robinson SD, Edwards DR, Zhou Z, Collins A, Bowles KM, Rushworth SA.

Oncogene. 2018 May;37(20):2676-2686. doi: 10.1038/s41388-018-0151-1. Epub 2018 Feb 28.


Pulling the plug - halting cancer's theft of mitochondria.

Marlein CR, Zaitseva L, Rushworth SA.

Oncoscience. 2017 Nov 2;4(11-12):173-174. doi: 10.18632/oncoscience.374. eCollection 2017 Nov. No abstract available.


NADPH oxidase-2 derived superoxide drives mitochondrial transfer from bone marrow stromal cells to leukemic blasts.

Marlein CR, Zaitseva L, Piddock RE, Robinson SD, Edwards DR, Shafat MS, Zhou Z, Lawes M, Bowles KM, Rushworth SA.

Blood. 2017 Oct 5;130(14):1649-1660. doi: 10.1182/blood-2017-03-772939. Epub 2017 Jul 21.


Front-line glioblastoma chemotherapeutic temozolomide is toxic to Trypanosoma brucei and potently enhances melarsoprol and eflornithine.

Steverding D, Rushworth SA.

Exp Parasitol. 2017 Jul;178:45-50. doi: 10.1016/j.exppara.2017.05.006. Epub 2017 May 25.


Inflammatory Differences in Plaque Erosion and Rupture in Patients With ST-Segment Elevation Myocardial Infarction.

Chandran S, Watkins J, Abdul-Aziz A, Shafat M, Calvert PA, Bowles KM, Flather MD, Rushworth SA, Ryding AD.

J Am Heart Assoc. 2017 May 3;6(5). pii: e005868. doi: 10.1161/JAHA.117.005868.


The Role of PI3K Isoforms in Regulating Bone Marrow Microenvironment Signaling Focusing on Acute Myeloid Leukemia and Multiple Myeloma.

Piddock RE, Bowles KM, Rushworth SA.

Cancers (Basel). 2017 Mar 28;9(4). pii: E29. doi: 10.3390/cancers9040029. Review.


The bone marrow microenvironment - Home of the leukemic blasts.

Shafat MS, Gnaneswaran B, Bowles KM, Rushworth SA.

Blood Rev. 2017 Sep;31(5):277-286. doi: 10.1016/j.blre.2017.03.004. Epub 2017 Mar 12. Review.


Leukemic blasts program bone marrow adipocytes to generate a protumoral microenvironment.

Shafat MS, Oellerich T, Mohr S, Robinson SD, Edwards DR, Marlein CR, Piddock RE, Fenech M, Zaitseva L, Abdul-Aziz A, Turner J, Watkins JA, Lawes M, Bowles KM, Rushworth SA.

Blood. 2017 Mar 9;129(10):1320-1332. doi: 10.1182/blood-2016-08-734798. Epub 2017 Jan 3.


MIF-Induced Stromal PKCβ/IL8 Is Essential in Human Acute Myeloid Leukemia.

Abdul-Aziz AM, Shafat MS, Mehta TK, Di Palma F, Lawes MJ, Rushworth SA, Bowles KM.

Cancer Res. 2017 Jan 15;77(2):303-311. doi: 10.1158/0008-5472.CAN-16-1095. Epub 2016 Nov 21.


Targeting PI3Kδ and PI3Kγ signalling disrupts human AML survival and bone marrow stromal cell mediated protection.

Pillinger G, Loughran NV, Piddock RE, Shafat MS, Zaitseva L, Abdul-Aziz A, Lawes MJ, Bowles KM, Rushworth SA.

Oncotarget. 2016 Jun 28;7(26):39784-39795. doi: 10.18632/oncotarget.9289.


Trypanocidal and cysteine protease inhibitory activity of isopentyl caffeate is not linked in Trypanosoma brucei.

Steverding D, da Nóbrega FR, Rushworth SA, de Sousa DP.

Parasitol Res. 2016 Nov;115(11):4397-4403. Epub 2016 Aug 18.


Activity of Bruton's tyrosine-kinase inhibitor ibrutinib in patients with CD117-positive acute myeloid leukaemia: a mechanistic study using patient-derived blast cells.

Rushworth SA, Pillinger G, Abdul-Aziz A, Piddock R, Shafat MS, Murray MY, Zaitseva L, Lawes MJ, MacEwan DJ, Bowles KM.

Lancet Haematol. 2015 May;2(5):e204-11. doi: 10.1016/S2352-3026(15)00046-0. Epub 2015 Apr 14.


Targeting BTK for the treatment of FLT3-ITD mutated acute myeloid leukemia.

Pillinger G, Abdul-Aziz A, Zaitseva L, Lawes M, MacEwan DJ, Bowles KM, Rushworth SA.

Sci Rep. 2015 Aug 21;5:12949. doi: 10.1038/srep12949.


Oxidative stress responses and NRF2 in human leukaemia.

Abdul-Aziz A, MacEwan DJ, Bowles KM, Rushworth SA.

Oxid Med Cell Longev. 2015;2015:454659. doi: 10.1155/2015/454659. Epub 2015 Mar 30. Review.


Ibrutinib inhibits BTK-driven NF-κB p65 activity to overcome bortezomib-resistance in multiple myeloma.

Murray MY, Zaitseva L, Auger MJ, Craig JI, MacEwan DJ, Rushworth SA, Bowles KM.

Cell Cycle. 2015;14(14):2367-75. doi: 10.1080/15384101.2014.998067. Epub 2015 Jan 7.

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