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Items: 19

  • Showing results for stephen kaiser. Your search for Stephen Haiser retrieved no results.
1.

Discovery of a Novel and Selective Indoleamine 2,3-Dioxygenase (IDO-1) Inhibitor 3-(5-Fluoro-1H-indol-3-yl)pyrrolidine-2,5-dione (EOS200271/PF-06840003) and Its Characterization as a Potential Clinical Candidate.

Crosignani S, Bingham P, Bottemanne P, Cannelle H, Cauwenberghs S, Cordonnier M, Dalvie D, Deroose F, Feng JL, Gomes B, Greasley S, Kaiser SE, Kraus M, Négrerie M, Maegley K, Miller N, Murray BW, Schneider M, Soloweij J, Stewart AE, Tumang J, Torti VR, Van Den Eynde B, Wythes M.

J Med Chem. 2017 Dec 14;60(23):9617-9629. doi: 10.1021/acs.jmedchem.7b00974. Epub 2017 Nov 21.

PMID:
29111717
2.

Targeting S-adenosylmethionine biosynthesis with a novel allosteric inhibitor of Mat2A.

Quinlan CL, Kaiser SE, Bolaños B, Nowlin D, Grantner R, Karlicek-Bryant S, Feng JL, Jenkinson S, Freeman-Cook K, Dann SG, Wang X, Wells PA, Fantin VR, Stewart AE, Grant SK.

Nat Chem Biol. 2017 Jul;13(7):785-792. doi: 10.1038/nchembio.2384. Epub 2017 May 29.

PMID:
28553945
3.

Chemoselective Preparation of Clickable Aryl Sulfonyl Fluoride Monomers: A Toolbox of Highly Functionalized Intermediates for Chemical Biology Probe Synthesis.

Fadeyi O, Parikh MD, Chen MZ, Kyne RE Jr, Taylor AP, O'Doherty I, Kaiser SE, Barbas S, Niessen S, Shi M, Weinrich SL, Kath JC, Jones LH, Robinson RP.

Chembiochem. 2016 Oct 17;17(20):1925-1930. doi: 10.1002/cbic.201600427. Epub 2016 Aug 30.

PMID:
27504718
4.

The Unfolded Protein Response Triggers Site-Specific Regulatory Ubiquitylation of 40S Ribosomal Proteins.

Higgins R, Gendron JM, Rising L, Mak R, Webb K, Kaiser SE, Zuzow N, Riviere P, Yang B, Fenech E, Tang X, Lindsay SA, Christianson JC, Hampton RY, Wasserman SA, Bennett EJ.

Mol Cell. 2015 Jul 2;59(1):35-49. doi: 10.1016/j.molcel.2015.04.026. Epub 2015 Jun 4.

5.

Binding to E1 and E3 is mutually exclusive for the human autophagy E2 Atg3.

Qiu Y, Hofmann K, Coats JE, Schulman BA, Kaiser SE.

Protein Sci. 2013 Dec;22(12):1691-7. doi: 10.1002/pro.2381.

6.

Structures of Atg7-Atg3 and Atg7-Atg10 reveal noncanonical mechanisms of E2 recruitment by the autophagy E1.

Kaiser SE, Qiu Y, Coats JE, Mao K, Klionsky DJ, Schulman BA.

Autophagy. 2013 May;9(5):778-80. doi: 10.4161/auto.23644. Epub 2013 Feb 6.

7.

ALIX is a Lys63-specific polyubiquitin binding protein that functions in retrovirus budding.

Dowlatshahi DP, Sandrin V, Vivona S, Shaler TA, Kaiser SE, Melandri F, Sundquist WI, Kopito RR.

Dev Cell. 2012 Dec 11;23(6):1247-54. doi: 10.1016/j.devcel.2012.10.023. Epub 2012 Nov 29.

8.

Noncanonical E2 recruitment by the autophagy E1 revealed by Atg7-Atg3 and Atg7-Atg10 structures.

Kaiser SE, Mao K, Taherbhoy AM, Yu S, Olszewski JL, Duda DM, Kurinov I, Deng A, Fenn TD, Klionsky DJ, Schulman BA.

Nat Struct Mol Biol. 2012 Dec;19(12):1242-9. doi: 10.1038/nsmb.2415. Epub 2012 Nov 11.

9.

Ubiquitin-like modifiers.

Taherbhoy AM, Schulman BA, Kaiser SE.

Essays Biochem. 2012;52:51-63. doi: 10.1042/bse0520051. Review.

PMID:
22708563
10.

Indirect inhibition of 26S proteasome activity in a cellular model of Huntington's disease.

Hipp MS, Patel CN, Bersuker K, Riley BE, Kaiser SE, Shaler TA, Brandeis M, Kopito RR.

J Cell Biol. 2012 Mar 5;196(5):573-87. doi: 10.1083/jcb.201110093. Epub 2012 Feb 27.

11.

Trans mechanism for ubiquitin-like protein transfer in autophagy.

Taherbhoy AM, Kaiser SE, Schulman BA.

Cell Cycle. 2012 Feb 15;11(4):635-6. doi: 10.4161/cc.11.4.19277. Epub 2012 Feb 15. No abstract available.

PMID:
22313730
12.

Specific recognition of linear ubiquitin chains by the Npl4 zinc finger (NZF) domain of the HOIL-1L subunit of the linear ubiquitin chain assembly complex.

Sato Y, Fujita H, Yoshikawa A, Yamashita M, Yamagata A, Kaiser SE, Iwai K, Fukai S.

Proc Natl Acad Sci U S A. 2011 Dec 20;108(51):20520-5. doi: 10.1073/pnas.1109088108. Epub 2011 Dec 2.

13.

Atg8 transfer from Atg7 to Atg3: a distinctive E1-E2 architecture and mechanism in the autophagy pathway.

Taherbhoy AM, Tait SW, Kaiser SE, Williams AH, Deng A, Nourse A, Hammel M, Kurinov I, Rock CO, Green DR, Schulman BA.

Mol Cell. 2011 Nov 4;44(3):451-61. doi: 10.1016/j.molcel.2011.08.034.

14.

Protein standard absolute quantification (PSAQ) method for the measurement of cellular ubiquitin pools.

Kaiser SE, Riley BE, Shaler TA, Trevino RS, Becker CH, Schulman H, Kopito RR.

Nat Methods. 2011 Jul 10;8(8):691-6. doi: 10.1038/nmeth.1649.

15.

Autophagy inhibition engages Nrf2-p62 Ub-associated signaling.

Riley BE, Kaiser SE, Kopito RR.

Autophagy. 2011 Mar;7(3):338-40. No abstract available.

16.

Ubiquitin accumulation in autophagy-deficient mice is dependent on the Nrf2-mediated stress response pathway: a potential role for protein aggregation in autophagic substrate selection.

Riley BE, Kaiser SE, Shaler TA, Ng AC, Hara T, Hipp MS, Lage K, Xavier RJ, Ryu KY, Taguchi K, Yamamoto M, Tanaka K, Mizushima N, Komatsu M, Kopito RR.

J Cell Biol. 2010 Nov 1;191(3):537-52. doi: 10.1083/jcb.201005012.

17.

Conservation of mechanism, variation of rate: folding kinetics of three homologous four-helix bundle proteins.

Dalal S, Canet D, Kaiser SE, Dobson CM, Regan L.

Protein Eng Des Sel. 2008 Mar;21(3):197-206. doi: 10.1093/protein/gzm088.

PMID:
18299293
18.

The structure of the yeast plasma membrane SNARE complex reveals destabilizing water-filled cavities.

Strop P, Kaiser SE, Vrljic M, Brunger AT.

J Biol Chem. 2008 Jan 11;283(2):1113-9. Epub 2007 Oct 22.

19.

Structural basis of FFAT motif-mediated ER targeting.

Kaiser SE, Brickner JH, Reilein AR, Fenn TD, Walter P, Brunger AT.

Structure. 2005 Jul;13(7):1035-45.

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