Format

Send to

Choose Destination

See 1 citation found using an alternative search:

Cell Death Differ. 2012 Feb;19(2):267-73. doi: 10.1038/cdd.2011.92. Epub 2011 Jul 1.

VDAC1 selectively transfers apoptotic Ca2+ signals to mitochondria.

Author information

1
Department of Biomedical Sciences, University of Padova and CNR Neuroscience Institute, Padua, Italy.

Abstract

Voltage-dependent anion channels (VDACs) are expressed in three isoforms, with common channeling properties and different roles in cell survival. We show that VDAC1 silencing potentiates apoptotic challenges, whereas VDAC2 has the opposite effect. Although all three VDAC isoforms are equivalent in allowing mitochondrial Ca(2+) loading upon agonist stimulation, VDAC1 silencing selectively impairs the transfer of the low-amplitude apoptotic Ca(2+) signals. Co-immunoprecipitation experiments show that VDAC1, but not VDAC2 and VDAC3, forms complexes with IP(3) receptors, an interaction that is further strengthened by apoptotic stimuli. These data highlight a non-redundant molecular route for transferring Ca(2+) signals to mitochondria in apoptosis.

PMID:
21720385
PMCID:
PMC3263501
DOI:
10.1038/cdd.2011.92
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Nature Publishing Group Icon for PubMed Central
Loading ...
Support Center