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Platelet-Specific Deletion of Cyclooxygenase-1 Ameliorates Dextran Sulfate Sodium-Induced Colitis in Mice.

Sacco A, Bruno A, Contursi A, Dovizio M, Tacconelli S, Ricciotti E, Guillem-Llobat P, Salvatore T, Di Francesco L, Fullone R, Ballerini P, Arena V, Alberti S, Liu G, Gong Y, Sgambato A, Patrono C, FitzGerald GA, Yu Y, Patrignani P.

J Pharmacol Exp Ther. 2019 Sep;370(3):416-426. doi: 10.1124/jpet.119.259382. Epub 2019 Jun 27.


miR-574-5p as RNA decoy for CUGBP1 stimulates human lung tumor growth by mPGES-1 induction.

Saul MJ, Baumann I, Bruno A, Emmerich AC, Wellstein J, Ottinger SM, Contursi A, Dovizio M, Donnini S, Tacconelli S, Raouf J, Idborg H, Stein S, Korotkova M, Savai R, Terzuoli E, Sala G, Seeger W, Jakobsson PJ, Patrignani P, Suess B, Steinhilber D.

FASEB J. 2019 Jun;33(6):6933-6947. doi: 10.1096/fj.201802547R. Epub 2019 Mar 28.


Antithrombotic Agents and Cancer.

Bruno A, Dovizio M, Tacconelli S, Contursi A, Ballerini P, Patrignani P.

Cancers (Basel). 2018 Jul 31;10(8). pii: E253. doi: 10.3390/cancers10080253. Review.


Reduced Variability to Aspirin Antiplatelet Effect by the Coadministration of Statins in High-Risk Patients for Cardiovascular Disease.

Tacconelli S, Dovizio M, Di Francesco L, Meneguzzi A, D'Agostino I, Evangelista V, Manarini S, Capone ML, Grossi L, Porreca E, Di Febbo C, Bruno A, Ballerini P, Levantesi G, Fava C, Minuz P, Patrignani P.

Clin Pharmacol Ther. 2018 Jul;104(1):111-119. doi: 10.1002/cpt.1075. Epub 2018 Apr 19.


P2Y12 Receptors in Tumorigenesis and Metastasis.

Ballerini P, Dovizio M, Bruno A, Tacconelli S, Patrignani P.

Front Pharmacol. 2018 Feb 2;9:66. doi: 10.3389/fphar.2018.00066. eCollection 2018. Review.


Nonsteroidal anti-inflammatory drugs and cardiovascular safety - translating pharmacological data into clinical readouts.

Tacconelli S, Bruno A, Grande R, Ballerini P, Patrignani P.

Expert Opin Drug Saf. 2017 Jul;16(7):791-807. doi: 10.1080/14740338.2017.1338272. Epub 2017 Jun 8. Review.


Dysregulated post-transcriptional control of COX-2 gene expression in gestational diabetic endothelial cells.

Di Francesco L, Dovizio M, Trenti A, Marcantoni E, Moore A, O'Gaora P, McCarthy C, Tacconelli S, Bruno A, Alberti S, Gizzo S, Nardelli GB, Orso G, Belton O, Trevisi L, Dixon DA, Patrignani P.

Br J Pharmacol. 2015 Sep;172(18):4575-4587. doi: 10.1111/bph.13241. Epub 2015 Aug 3.


Inside epoxyeicosatrienoic acids and cardiovascular disease.

Tacconelli S, Patrignani P.

Front Pharmacol. 2014 Nov 10;5:239. doi: 10.3389/fphar.2014.00239. eCollection 2014. Review.


Gut microbiota, host gene expression, and aging.

Patrignani P, Tacconelli S, Bruno A.

J Clin Gastroenterol. 2014 Nov-Dec;48 Suppl 1:S28-31. doi: 10.1097/MCG.0000000000000229. Review.


Variability in the response to non-steroidal anti-inflammatory drugs: mechanisms and perspectives.

Bruno A, Tacconelli S, Patrignani P.

Basic Clin Pharmacol Toxicol. 2014 Jan;114(1):56-63. doi: 10.1111/bcpt.12117. Epub 2013 Sep 3. Review.


Synthesis, pharmacological characterization, and docking analysis of a novel family of diarylisoxazoles as highly selective cyclooxygenase-1 (COX-1) inhibitors.

Vitale P, Tacconelli S, Perrone MG, Malerba P, Simone L, Scilimati A, Lavecchia A, Dovizio M, Marcantoni E, Bruno A, Patrignani P.

J Med Chem. 2013 Jun 13;56(11):4277-99. doi: 10.1021/jm301905a. Epub 2013 May 16.


Mechanisms of the antitumoural effects of aspirin in the gastrointestinal tract.

Bruno A, Dovizio M, Tacconelli S, Patrignani P.

Best Pract Res Clin Gastroenterol. 2012 Aug;26(4):e1-e13. doi: 10.1016/j.bpg.2012.10.001. Review.


Coxibs: pharmacology, toxicity and efficacy in cancer clinical trials.

Garcia Rodriguez LA, Cea-Soriano L, Tacconelli S, Patrignani P.

Recent Results Cancer Res. 2013;191:67-93. doi: 10.1007/978-3-642-30331-9_4. Review.


Mode of action of aspirin as a chemopreventive agent.

Dovizio M, Bruno A, Tacconelli S, Patrignani P.

Recent Results Cancer Res. 2013;191:39-65. doi: 10.1007/978-3-642-30331-9_3. Review.


Oxidative damage, platelet activation, and inflammation to predict mobility disability and mortality in older persons: results from the health aging and body composition study.

Cesari M, Kritchevsky SB, Nicklas B, Kanaya AM, Patrignani P, Tacconelli S, Tranah GJ, Tognoni G, Harris TB, Incalzi RA, Newman AB, Pahor M; Health ABC study.

J Gerontol A Biol Sci Med Sci. 2012 Jun;67(6):671-6. doi: 10.1093/gerona/glr246. Epub 2012 Mar 1.


Effects of estrogen on endothelial prostanoid production and cyclooxygenase-2 and heme oxygenase-1 expression.

Marcantoni E, Di Francesco L, Totani L, Piccoli A, Evangelista V, Tacconelli S, Patrignani P.

Prostaglandins Other Lipid Mediat. 2012 Aug;98(3-4):122-8. doi: 10.1016/j.prostaglandins.2012.01.006. Epub 2012 Feb 6.


Effects of celecoxib on prostanoid biosynthesis and circulating angiogenesis proteins in familial adenomatous polyposis.

Dovizio M, Tacconelli S, Ricciotti E, Bruno A, Maier TJ, Anzellotti P, Di Francesco L, Sala P, Signoroni S, Bertario L, Dixon DA, Lawson JA, Steinhilber D, FitzGerald GA, Patrignani P.

J Pharmacol Exp Ther. 2012 Apr;341(1):242-50. doi: 10.1124/jpet.111.190785. Epub 2012 Jan 19.


Mechanistic and pharmacological issues of aspirin as an anticancer agent.

Dovizio M, Tacconelli S, Sostres C, Ricciotti E, Patrignani P.

Pharmaceuticals (Basel). 2012 Dec 5;5(12):1346-71. doi: 10.3390/ph5121346.


Managing the adverse effects of nonsteroidal anti-inflammatory drugs.

Patrignani P, Tacconelli S, Bruno A, Sostres C, Lanas A.

Expert Rev Clin Pharmacol. 2011 Sep;4(5):605-21. doi: 10.1586/ecp.11.36. Review.


Glucose and collagen regulate human platelet activity through aldose reductase induction of thromboxane.

Tang WH, Stitham J, Gleim S, Di Febbo C, Porreca E, Fava C, Tacconelli S, Capone M, Evangelista V, Levantesi G, Wen L, Martin K, Minuz P, Rade J, Patrignani P, Hwa J.

J Clin Invest. 2011 Nov;121(11):4462-76. doi: 10.1172/JCI59291. Epub 2011 Oct 17.

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