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Items: 1 to 20 of 29


Modulation of Agrin and RhoA Pathways Ameliorates Movement Defects and Synapse Morphology in MYO9A-Depleted Zebrafish.

O'Connor E, Cairns G, Spendiff S, Burns D, Hettwer S, Mäder A, Müller J, Horvath R, Slater C, Roos A, Lochmüller H.

Cells. 2019 Aug 7;8(8). pii: E848. doi: 10.3390/cells8080848.


Plasma C-terminal agrin fragment and rapid kidney function decline in chronic kidney disease patients.

Lorenz G, Hettwer S, McCallum W, Angermann S, Wen M, Schmaderer C, Heemann U, Roos M, Renders L, Steubl D.

Medicine (Baltimore). 2019 May;98(19):e15597. doi: 10.1097/MD.0000000000015597.


MYO9A deficiency in motor neurons is associated with reduced neuromuscular agrin secretion.

O'Connor E, Phan V, Cordts I, Cairns G, Hettwer S, Cox D, Lochmüller H, Roos A.

Hum Mol Genet. 2018 Apr 15;27(8):1434-1446. doi: 10.1093/hmg/ddy054.


Increasing Agrin Function Antagonizes Muscle Atrophy and Motor Impairment in Spinal Muscular Atrophy.

Boido M, De Amicis E, Valsecchi V, Trevisan M, Ala U, Ruegg MA, Hettwer S, Vercelli A.

Front Cell Neurosci. 2018 Jan 30;12:17. doi: 10.3389/fncel.2018.00017. eCollection 2018.


Denervation drives mitochondrial dysfunction in skeletal muscle of octogenarians.

Spendiff S, Vuda M, Gouspillou G, Aare S, Perez A, Morais JA, Jagoe RT, Filion ME, Glicksman R, Kapchinsky S, MacMillan NJ, Pion CH, Aubertin-Leheudre M, Hettwer S, Correa JA, Taivassalo T, Hepple RT.

J Physiol. 2016 Dec 15;594(24):7361-7379. doi: 10.1113/JP272487. Epub 2016 Oct 23.


Failed reinnervation in aging skeletal muscle.

Aare S, Spendiff S, Vuda M, Elkrief D, Perez A, Wu Q, Mayaki D, Hussain SN, Hettwer S, Hepple RT.

Skelet Muscle. 2016 Sep 1;6(1):29. doi: 10.1186/s13395-016-0101-y. eCollection 2016.


The C-Terminal Fragment of Agrin (CAF), a Novel Marker of Renal Function, Is Filtered by the Kidney and Reabsorbed by the Proximal Tubule.

Daryadel A, Haubitz M, Figueiredo M, Steubl D, Roos M, Mäder A, Hettwer S, Wagner CA.

PLoS One. 2016 Jul 5;11(7):e0157905. doi: 10.1371/journal.pone.0157905. eCollection 2016.


Evaluation of C-terminal Agrin Fragment as a marker of muscle wasting in patients after acute stroke during early rehabilitation.

Scherbakov N, Knops M, Ebner N, Valentova M, Sandek A, Grittner U, Dahinden P, Hettwer S, Schefold JC, von Haehling S, Anker SD, Joebges M, Doehner W.

J Cachexia Sarcopenia Muscle. 2016 Mar;7(1):60-7. doi: 10.1002/jcsm.12068. Epub 2015 Oct 27.


Comparison of Peritoneal Low-Molecular-Weight-Protein-Removal in CCPD and CAPD Patients Based on C-Terminal Agrin Fragment Clearance.

Steubl D, Roos M, Hettwer S, Angermann S, Wen M, Schmaderer C, Luppa P, Heemann U, Renders L.

Kidney Blood Press Res. 2016;41(2):175-85. doi: 10.1159/000443419. Epub 2016 Mar 10.


Plasma total C-terminal agrin fragment (tCAF) as a marker for kidney function in patients with chronic kidney disease.

Steubl D, Roos M, Hettwer S, Satanovskij R, Tholen S, Wen M, Schmaderer C, Hasenau AL, Luppa P, Stecher L, Heemann U, Renders L.

Clin Chem Lab Med. 2016 Sep 1;54(9):1487-95. doi: 10.1515/cclm-2015-1027.


C-Terminal Fragment of Agrin (CAF): A Novel Marker for Progression of Kidney Disease in Type 2 Diabetics.

Devetzis V, Daryadel A, Roumeliotis S, Theodoridis M, Wagner CA, Hettwer S, Huynh-Do U, Ploumis P, Arampatzis S.

PLoS One. 2015 Dec 2;10(12):e0143524. doi: 10.1371/journal.pone.0143524. eCollection 2015.


Detection of muscle wasting in patients with chronic heart failure using C-terminal agrin fragment: results from the Studies Investigating Co-morbidities Aggravating Heart Failure (SICA-HF).

Steinbeck L, Ebner N, Valentova M, Bekfani T, Elsner S, Dahinden P, Hettwer S, Scherbakov N, Schefold JC, Sandek A, Springer J, Doehner W, Anker SD, von Haehling S.

Eur J Heart Fail. 2015 Dec;17(12):1283-93. doi: 10.1002/ejhf.400. Epub 2015 Oct 9.


Early postoperative C-terminal agrin fragment (CAF) serum levels predict graft loss and proteinuria in renal transplant recipients.

Steubl D, Vogel A, Hettwer S, Tholen S, Luppa PB, Rondak IC, Renders L, Heemann U, Roos M.

Clin Chem Lab Med. 2016 Jan;54(1):63-72. doi: 10.1515/cclm-2015-0369.


C-terminal agrin fragment (CAF) reflects renal function in patients suffering from severe sepsis or septic shock.

Drey M, Behnes M, Kob R, Lepiorz D, Hettwer S, Bollheimer C, Sieber CC, Bertsch T, Hoffmann U.

Clin Lab. 2015;61(1-2):69-76.


C-terminal agrin fragment (CAF) as a serum biomarker for residual renal function in peritoneal dialysis patients.

Steubl D, Hettwer S, Dahinden P, Luppa P, Rondak IC, Regenbogen C, Stock KF, Renders L, Heemann U, Roos M.

Int Urol Nephrol. 2015 Feb;47(2):391-6. doi: 10.1007/s11255-014-0852-5. Epub 2014 Oct 29.


Influence of high-flux hemodialysis and hemodiafiltration on serum C-terminal agrin fragment levels in end-stage renal disease patients.

Steubl D, Hettwer S, Dahinden P, Wolf P, Luppa P, Wagner CA, Küchle C, Schmaderer C, Renders L, Heemann U, Roos M.

Transl Res. 2014 Nov;164(5):392-9. doi: 10.1016/j.trsl.2014.05.005. Epub 2014 May 16.


Motoneuron loss is associated with sarcopenia.

Drey M, Krieger B, Sieber CC, Bauer JM, Hettwer S, Bertsch T; DISARCO Study Group.

J Am Med Dir Assoc. 2014 Jun;15(6):435-9. doi: 10.1016/j.jamda.2014.02.002. Epub 2014 Mar 18.


Elevated troponin in septic patients in the emergency department: frequency, causes, and prognostic implications.

Wilhelm J, Hettwer S, Schuermann M, Bagger S, Gerhardt F, Mundt S, Muschik S, Zimmermann J, Amoury M, Ebelt H, Werdan K.

Clin Res Cardiol. 2014 Jul;103(7):561-7. doi: 10.1007/s00392-014-0684-4. Epub 2014 Feb 18.


Injection of a soluble fragment of neural agrin (NT-1654) considerably improves the muscle pathology caused by the disassembly of the neuromuscular junction.

Hettwer S, Lin S, Kucsera S, Haubitz M, Oliveri F, Fariello RG, Ruegg MA, Vrijbloed JW.

PLoS One. 2014 Feb 10;9(2):e88739. doi: 10.1371/journal.pone.0088739. eCollection 2014.


C-terminal agrin fragment--a new fast biomarker for kidney function in renal transplant recipients.

Steubl D, Hettwer S, Vrijbloed W, Dahinden P, Wolf P, Luppa P, Wagner CA, Renders L, Heemann U, Roos M.

Am J Nephrol. 2013;38(6):501-8. doi: 10.1159/000356969. Epub 2013 Dec 14.

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