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Nutrients. 2019 Jun 25;11(6). pii: E1426. doi: 10.3390/nu11061426.

In Search of Panacea-Review of Recent Studies Concerning Nature-Derived Anticancer Agents.

Author information

1
Faculty of Medicine, Wroclaw Medical University, J. Mikulicza-Radeckiego 5, 50-345 Wroclaw, Poland. dawid.przystupski@gmail.com.
2
Department of Biological Sciences, Institute of Experimental Biology, University of Wrocław, Kanonia 6/8, 50-328 Wroclaw, Poland. m.j.niemczura@gmail.com.
3
Department of Biological Sciences, Institute of Experimental Biology, University of Wrocław, Kanonia 6/8, 50-328 Wroclaw, Poland. agata_gorska@onet.eu.
4
Faculty of Medicine, Wroclaw Medical University, J. Mikulicza-Radeckiego 5, 50-345 Wroclaw, Poland. stkwiatek@gmail.com.
5
Faculty of Medicine, Wroclaw Medical University, J. Mikulicza-Radeckiego 5, 50-345 Wroclaw, Poland. krzysztof.kotowski96@gmail.com.
6
Faculty of Medicine, Wroclaw Medical University, J. Mikulicza-Radeckiego 5, 50-345 Wroclaw, Poland. piotr95wawryka@gmail.com.
7
Faculty of Chemistry, Wroclaw University of Science and Technology, Norwida 4/6, 50-373 Wroclaw, Poland. rozborska.paulina@gmail.com.
8
Faculty of Chemistry, Wroclaw University of Science and Technology, Norwida 4/6, 50-373 Wroclaw, Poland. kinga.wozniak@onet.eu.
9
Department of Medical Biochemistry, Wroclaw Medical University, Chalubinskiego 10, 50-368 13 Wroclaw, Poland. michel.olga.maria@gmail.com.
10
Faculty of Medicine, Wroclaw Medical University, J. Mikulicza-Radeckiego 5, 50-345 Wroclaw, Poland. akielbik6@gmail.com.
11
Faculty of Biotechnology, University of Wroclaw, Joliot-Curie 14a, 50-385 Wroclaw, Poland. weronikabartosik@gmail.com.
12
Department of Molecular and Cellular Biology, Wroclaw Medical University, Borowska 211A, 50-25 556 Wroclaw, Poland. jolanta.saczko@umed.wroc.pl.
13
Department of Molecular and Cellular Biology, Wroclaw Medical University, Borowska 211A, 50-25 556 Wroclaw, Poland. julita.kulbacka@umed.wroc.pl.

Abstract

Cancers are one of the leading causes of deaths affecting millions of people around the world, therefore they are currently a major public health problem. The treatment of cancer is based on surgical resection, radiotherapy, chemotherapy or immunotherapy, much of which is often insufficient and cause serious, burdensome and undesirable side effects. For many years, assorted secondary metabolites derived from plants have been used as antitumor agents. Recently, researchers have discovered a large number of new natural substances which can effectively interfere with cancer cells' metabolism. The most famous groups of these compounds are topoisomerase and mitotic inhibitors. The aim of the latest research is to characterize natural compounds found in many common foods, especially by means of their abilities to regulate cell cycle, growth and differentiation, as well as epigenetic modulation. In this paper, we focus on a review of recent discoveries regarding nature-derived anticancer agents.

KEYWORDS:

6-gingerol; anticancer research; chemoprevention; drug resistance; honokiol; mitotic inhibitors; natural substances; nutraceuticals; nutri-epigenetics; phytochemicals; polyphenols; topoisomerase inhibitors; xenobiotics

PMID:
31242602
PMCID:
PMC6627480
DOI:
10.3390/nu11061426
[Indexed for MEDLINE]
Free PMC Article

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