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Items: 20

1.

PKIDB: A Curated, Annotated and Updated Database of Protein Kinase Inhibitors in Clinical Trials.

Carles F, Bourg S, Meyer C, Bonnet P.

Molecules. 2018 Apr 15;23(4). pii: E908. doi: 10.3390/molecules23040908.

2.

Comprehensive Network Map of ADME-Tox Databases.

Canault B, Bourg S, Vayer P, Bonnet P.

Mol Inform. 2017 Oct;36(10). doi: 10.1002/minf.201700029. Epub 2017 Jun 29.

PMID:
28660674
3.

VSPrep: A General KNIME Workflow for the Preparation of Molecules for Virtual Screening.

Gally JM, Bourg S, Do QT, Aci-Sèche S, Bonnet P.

Mol Inform. 2017 Oct;36(10). doi: 10.1002/minf.201700023. Epub 2017 Jun 6.

PMID:
28586180
4.

Novel optimization of valmerins (tetrahydropyrido[1,2-a]isoindolones) as potent dual CDK5/GSK3 inhibitors.

Ouach A, Boulahjar R, Vala C, Bourg S, Bonnet P, Guguen-Guillouzo C, Ravache M, Le Guevel R, Lozach O, Lazar S, Troin Y, Meijer L, Ruchaud S, Akssira M, Guillaumet G, Routier S.

Eur J Med Chem. 2016 Jun 10;115:311-25. doi: 10.1016/j.ejmech.2016.02.072. Epub 2016 Mar 2.

PMID:
27019296
5.

Synthesis of dihydropyrimidine α,γ-diketobutanoic acid derivatives targeting HIV integrase.

Sari O, Roy V, Métifiot M, Marchand C, Pommier Y, Bourg S, Bonnet P, Schinazi RF, Agrofoglio LA.

Eur J Med Chem. 2015 Nov 2;104:127-38. doi: 10.1016/j.ejmech.2015.09.015. Epub 2015 Sep 25.

6.

Advances in tetrahydropyrido[1,2-a]isoindolone (valmerins) series: Potent glycogen synthase kinase 3 and cyclin dependent kinase 5 inhibitors.

Boulahjar R, Ouach A, Bourg S, Bonnet P, Lozach O, Meijer L, Guguen-Guillouzo C, Le Guevel R, Lazar S, Akssira M, Troin Y, Guillaumet G, Routier S.

Eur J Med Chem. 2015 Aug 28;101:274-87. doi: 10.1016/j.ejmech.2015.06.046. Epub 2015 Jun 27.

7.

Synthesis and optimization of an original V-shaped collection of 4-7-disubstituted pyrido[3,2-d]pyrimidines as CDK5 and DYRK1A inhibitors.

Dehbi O, Tikad A, Bourg S, Bonnet P, Lozach O, Meijer L, Aadil M, Akssira M, Guillaumet G, Routier S.

Eur J Med Chem. 2014 Jun 10;80:352-63. doi: 10.1016/j.ejmech.2014.04.055. Epub 2014 Apr 22.

PMID:
24793883
8.

Design, synthesis, and biological activity of pyridopyrimidine scaffolds as novel PI3K/mTOR dual inhibitors.

Saurat T, Buron F, Rodrigues N, de Tauzia ML, Colliandre L, Bourg S, Bonnet P, Guillaumet G, Akssira M, Corlu A, Guillouzo C, Berthier P, Rio P, Jourdan ML, Bénédetti H, Routier S.

J Med Chem. 2014 Feb 13;57(3):613-31. doi: 10.1021/jm401138v. Epub 2014 Jan 21.

PMID:
24345273
9.

Synthesis and biological evaluation of enantiomerically pure cyclopropyl analogues of combretastatin A4.

Ty N, Pontikis R, Chabot GG, Devillers E, Quentin L, Bourg S, Florent JC.

Bioorg Med Chem. 2013 Mar 1;21(5):1357-66. doi: 10.1016/j.bmc.2012.11.056. Epub 2012 Dec 21.

PMID:
23369686
10.

Mining collections of compounds with Screening Assistant 2.

Guilloux VL, Arrault A, Colliandre L, Bourg S, Vayer P, Morin-Allory L.

J Cheminform. 2012 Aug 31;4(1):20. doi: 10.1186/1758-2946-4-20.

11.

Synthesis and properties of 2'-O-neopentyl modified oligonucleotides.

Mathis G, Bourg S, Aci-Sèche S, Truffert JC, Asseline U.

Org Biomol Chem. 2013 Feb 28;11(8):1345-57. doi: 10.1039/c2ob26871j.

PMID:
23318410
12.

Efficient synthesis and first regioselective C-3 direct arylation of imidazo[1,2-b]pyrazoles.

Grosse S, Pillard C, Massip S, Léger JM, Jarry C, Bourg S, Bernard P, Guillaumet G.

Chemistry. 2012 Nov 19;18(47):14943-7. doi: 10.1002/chem.201202593. Epub 2012 Oct 19.

PMID:
23086664
13.

Novel tetrahydropyrido[1,2-a]isoindolone derivatives (valmerins): potent cyclin-dependent kinase/glycogen synthase kinase 3 inhibitors with antiproliferative activities and antitumor effects in human tumor xenografts.

Boulahjar R, Ouach A, Matteo C, Bourg S, Ravache M, le Guével R, Marionneau S, Oullier T, Lozach O, Meijer L, Guguen-Guillouzo C, Lazar S, Akssira M, Troin Y, Guillaumet G, Routier S.

J Med Chem. 2012 Nov 26;55(22):9589-606. doi: 10.1021/jm3008536. Epub 2012 Nov 1.

PMID:
23083119
14.

In vitro and in vivo biological evaluation of new 4,5-disubstituted 1,2,3-triazoles as cis-constrained analogs of combretastatin A4.

Mur Blanch N, Chabot GG, Quentin L, Scherman D, Bourg S, Dauzonne D.

Eur J Med Chem. 2012 Aug;54:22-32. doi: 10.1016/j.ejmech.2012.04.017. Epub 2012 May 9.

15.

Synthesis of chromeno[3,4-b]indoles as Lamellarin D analogues: a novel DYRK1A inhibitor class.

Neagoie C, Vedrenne E, Buron F, Mérour JY, Rosca S, Bourg S, Lozach O, Meijer L, Baldeyrou B, Lansiaux A, Routier S.

Eur J Med Chem. 2012 Mar;49:379-96. doi: 10.1016/j.ejmech.2012.01.040. Epub 2012 Jan 25.

PMID:
22305342
16.

Visual characterization and diversity quantification of chemical libraries: 2. Analysis and selection of size-independent, subspace-specific diversity indices.

Colliandre L, Le Guilloux V, Bourg S, Morin-Allory L.

J Chem Inf Model. 2012 Feb 27;52(2):327-42. doi: 10.1021/ci200535y. Epub 2012 Jan 5.

PMID:
22181665
17.

Synthesis and biological evaluation of new 3-(6-hydroxyindol-2-yl)-5-(Phenyl) pyridine or pyrazine V-Shaped molecules as kinase inhibitors and cytotoxic agents.

Kassis P, Brzeszcz J, Bénéteau V, Lozach O, Meijer L, Le Guével R, Guillouzo C, Lewiński K, Bourg S, Colliandre L, Routier S, Mérour JY.

Eur J Med Chem. 2011 Nov;46(11):5416-34. doi: 10.1016/j.ejmech.2011.08.048. Epub 2011 Sep 8.

PMID:
21944287
18.

Visual characterization and diversity quantification of chemical libraries: 1. creation of delimited reference chemical subspaces.

Le Guilloux V, Colliandre L, Bourg S, Guénegou G, Dubois-Chevalier J, Morin-Allory L.

J Chem Inf Model. 2011 Aug 22;51(8):1762-74. doi: 10.1021/ci200051r. Epub 2011 Aug 3.

PMID:
21761916
19.

Synthesis and structure-activity relationships of constrained heterocyclic analogues of combretastatin A4.

Arthuis M, Pontikis R, Chabot GG, Seguin J, Quentin L, Bourg S, Morin-Allory L, Florent JC.

ChemMedChem. 2011 Sep 5;6(9):1693-705. doi: 10.1002/cmdc.201100154. Epub 2011 Jul 5.

PMID:
21732536
20.

Design, synthesis and antiproliferative activities of biarylolefins based on polyhydroxylated and carbohydrate scaffolds.

Novoa A, Pellegrini-Moïse N, Bourg S, Thoret S, Dubois J, Aubert G, Cresteil T, Chapleur Y.

Eur J Med Chem. 2011 Sep;46(9):3570-80. doi: 10.1016/j.ejmech.2011.05.021. Epub 2011 May 13.

PMID:
21636180

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