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Items: 1 to 20 of 49


Elucidation of Molecular Mechanism of a Selective PPARα Modulator, Pemafibrate, through Combinational Approaches of X-ray Crystallography, Thermodynamic Analysis, and First-Principle Calculations.

Kawasaki M, Kambe A, Yamamoto Y, Arulmozhiraja S, Ito S, Nakagawa Y, Tokiwa H, Nakano S, Shimano H.

Int J Mol Sci. 2020 Jan 6;21(1). pii: E361. doi: 10.3390/ijms21010361.


High Salt Intake Worsens Aortic Dissection in Mice: Involvement of IL (Interleukin)-17A-Dependent ECM (Extracellular Matrix) Metabolism.

Nishida N, Aoki H, Ohno-Urabe S, Nishihara M, Furusho A, Hirakata S, Hayashi M, Ito S, Yamada H, Hirata Y, Yasukawa H, Imaizumi T, Tanaka H, Fukumoto Y.

Arterioscler Thromb Vasc Biol. 2020 Jan;40(1):189-205. doi: 10.1161/ATVBAHA.119.313336. Epub 2019 Nov 7.


Kinetics-Based Structural Requirements of Human Immunoglobulin G Binding Peptides.

Muguruma K, Fujita K, Fukuda A, Kishimoto S, Sakamoto S, Arima R, Ito M, Kawasaki M, Nakano S, Ito S, Shimizu K, Taguchi A, Takayama K, Taniguchi A, Ito Y, Hayashi Y.

ACS Omega. 2019 Aug 28;4(11):14390-14397. doi: 10.1021/acsomega.9b01104. eCollection 2019 Sep 10.


Competitive Binding Assay with an Umbelliferone-Based Fluorescent Rexinoid for Retinoid X Receptor Ligand Screening.

Yamada S, Kawasaki M, Fujihara M, Watanabe M, Takamura Y, Takioku M, Nishioka H, Takeuchi Y, Makishima M, Motoyama T, Ito S, Tokiwa H, Nakano S, Kakuta H.

J Med Chem. 2019 Oct 10;62(19):8809-8818. doi: 10.1021/acs.jmedchem.9b00995. Epub 2019 Sep 18.


Human TRPA1 activation by terpenes derived from the essential oil of daidai, Citrus aurantium L. var. daidai Makino.

Terada Y, Yamashita R, Ihara N, Yamazaki-Ito T, Takahashi Y, Masuda H, Sakuragawa S, Ito S, Ito K, Watanabe T.

Biosci Biotechnol Biochem. 2019 Sep;83(9):1721-1728. doi: 10.1080/09168451.2019.1611405. Epub 2019 May 10.


Following the Evolutionary Track of a Highly Specific l-Arginine Oxidase by Reconstruction and Biochemical Analysis of Ancestral and Native Enzymes.

Nakano S, Niwa M, Asano Y, Ito S.

Appl Environ Microbiol. 2019 May 30;85(12). pii: e00459-19. doi: 10.1128/AEM.00459-19. Print 2019 Jun 15.


Dual conformation of the ligand induces the partial agonistic activity of retinoid X receptor α (RXRα).

Miyashita Y, Numoto N, Arulmozhiraja S, Nakano S, Matsuo N, Shimizu K, Shibahara O, Fujihara M, Kakuta H, Ito S, Ikura T, Ito N, Tokiwa H.

FEBS Lett. 2019 Jan;593(2):242-250. doi: 10.1002/1873-3468.13301. Epub 2018 Dec 21.


Development of an Analysis Toolkit, AnalysisFMO, to Visualize Interaction Energies Generated by Fragment Molecular Orbital Calculations.

Tokiwa T, Nakano S, Yamamoto Y, Ishikawa T, Ito S, Sladek V, Fukuzawa K, Mochizuki Y, Tokiwa H, Misaizu F, Shigeta Y.

J Chem Inf Model. 2019 Jan 28;59(1):25-30. doi: 10.1021/acs.jcim.8b00649. Epub 2018 Dec 20.


Identification of soybean peptide leginsulin variants in different cultivars and their insulin-like activities.

Hashidume T, Sakano T, Mochizuki A, Ito K, Ito S, Kawarasaki Y, Miyoshi N.

Sci Rep. 2018 Nov 15;8(1):16847. doi: 10.1038/s41598-018-35331-5.


Improvement of ST0452 N-Acetylglucosamine-1-Phosphate Uridyltransferase Activity by the Cooperative Effect of Two Single Mutations Identified through Structure-Based Protein Engineering.

Honda Y, Nakano S, Ito S, Dadashipour M, Zhang Z, Kawarabayasi Y.

Appl Environ Microbiol. 2018 Nov 30;84(24). pii: e02213-18. doi: 10.1128/AEM.02213-18. Print 2018 Dec 15.


Computational Molecular Docking and X-ray Crystallographic Studies of Catechins in New Drug Design Strategies.

Nakano S, Megro SI, Hase T, Suzuki T, Isemura M, Nakamura Y, Ito S.

Molecules. 2018 Aug 13;23(8). pii: E2020. doi: 10.3390/molecules23082020. Review.


Pulmonary torsion after open esophagectomy for esophageal cancer: a case report and review.

Shiomi K, Yamashita K, Arai M, Ito S, Hayashi S, Ono M, Naito M, Mikubo M, Matsui Y, Satoh Y.

J Thorac Dis. 2018 Jun;10(6):E462-E468. doi: 10.21037/jtd.2018.05.194. No abstract available.


In Vitro and In Silico Studies of the Molecular Interactions of Epigallocatechin-3-O-gallate (EGCG) with Proteins That Explain the Health Benefits of Green Tea.

Saeki K, Hayakawa S, Nakano S, Ito S, Oishi Y, Suzuki Y, Isemura M.

Molecules. 2018 May 28;23(6). pii: E1295. doi: 10.3390/molecules23061295. Review.


Benchmark Analysis of Native and Artificial NAD+-Dependent Enzymes Generated by a Sequence-Based Design Method with or without Phylogenetic Data.

Nakano S, Motoyama T, Miyashita Y, Ishizuka Y, Matsuo N, Tokiwa H, Shinoda S, Asano Y, Ito S.

Biochemistry. 2018 Jul 3;57(26):3722-3732. doi: 10.1021/acs.biochem.8b00339. Epub 2018 Jun 4.


Binding of Catechins to Staphylococcal Enterotoxin A.

Shimamura Y, Utsumi M, Hirai C, Nakano S, Ito S, Tsuji A, Ishii T, Hosoya T, Kan T, Ohashi N, Masuda S.

Molecules. 2018 May 9;23(5). pii: E1125. doi: 10.3390/molecules23051125.


Involvement of B Cells, Immunoglobulins, and Syk in the Pathogenesis of Abdominal Aortic Aneurysm.

Furusho A, Aoki H, Ohno-Urabe S, Nishihara M, Hirakata S, Nishida N, Ito S, Hayashi M, Imaizumi T, Hiromatsu S, Akashi H, Tanaka H, Fukumoto Y.

J Am Heart Assoc. 2018 Mar 15;7(6). pii: e007750. doi: 10.1161/JAHA.117.007750.


Role of Macrophage Socs3 in the Pathogenesis of Aortic Dissection.

Ohno-Urabe S, Aoki H, Nishihara M, Furusho A, Hirakata S, Nishida N, Ito S, Hayashi M, Yasukawa H, Imaizumi T, Akashi H, Tanaka H, Fukumoto Y.

J Am Heart Assoc. 2018 Jan 17;7(2). pii: e007389. doi: 10.1161/JAHA.117.007389.


Product Release Mechanism Associated with Structural Changes in Monomeric l-Threonine 3-Dehydrogenase.

Motoyama T, Nakano S, Yamamoto Y, Tokiwa H, Asano Y, Ito S.

Biochemistry. 2017 Oct 31;56(43):5758-5770. doi: 10.1021/acs.biochem.7b00832. Epub 2017 Oct 19.


The role of IL-6 in pathogenesis of abdominal aortic aneurysm in mice.

Nishihara M, Aoki H, Ohno S, Furusho A, Hirakata S, Nishida N, Ito S, Hayashi M, Imaizumi T, Fukumoto Y.

PLoS One. 2017 Oct 5;12(10):e0185923. doi: 10.1371/journal.pone.0185923. eCollection 2017.


Origin of Stereoselectivity and Substrate/Ligand Recognition in an FAD-Dependent R-Selective Amine Oxidase.

Nakano S, Yasukawa K, Tokiwa T, Ishikawa T, Ishitsubo E, Matsuo N, Ito S, Tokiwa H, Asano Y.

J Phys Chem B. 2016 Oct 20;120(41):10736-10743. doi: 10.1021/acs.jpcb.6b09328. Epub 2016 Oct 10.


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