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Items: 1 to 20 of 74

1.

C. elegans expressing D76N β2-microglobulin: a model for in vivo screening of drug candidates targeting amyloidosis.

Faravelli G, Raimondi S, Marchese L, Partridge FA, Soria C, Mangione PP, Canetti D, Perni M, Aprile FA, Zorzoli I, Di Schiavi E, Lomas DA, Bellotti V, Sattelle DB, Giorgetti S.

Sci Rep. 2019 Dec 27;9(1):19960. doi: 10.1038/s41598-019-56498-5.

2.

S-Homocysteinylation effects on transthyretin: worsening of cardiomyopathy onset.

Leri M, Rebuzzini P, Caselli A, Luti S, Natalello A, Giorgetti S, Marchese L, Garagna S, Stefani M, Paoli P, Bucciantini M.

Biochim Biophys Acta Gen Subj. 2020 Jan;1864(1):129453. doi: 10.1016/j.bbagen.2019.129453. Epub 2019 Oct 29.

PMID:
31676294
3.

Targeting Amyloid Aggregation: An Overview of Strategies and Mechanisms.

Giorgetti S, Greco C, Tortora P, Aprile FA.

Int J Mol Sci. 2018 Sep 9;19(9). pii: E2677. doi: 10.3390/ijms19092677. Review.

4.

A FTIR microspectroscopy study of the structural and biochemical perturbations induced by natively folded and aggregated transthyretin in HL-1 cardiomyocytes.

Ami D, Mereghetti P, Leri M, Giorgetti S, Natalello A, Doglia SM, Stefani M, Bucciantini M.

Sci Rep. 2018 Aug 21;8(1):12508. doi: 10.1038/s41598-018-30995-5.

5.

Plasminogen activation triggers transthyretin amyloidogenesis in vitro.

Mangione PP, Verona G, Corazza A, Marcoux J, Canetti D, Giorgetti S, Raimondi S, Stoppini M, Esposito M, Relini A, Canale C, Valli M, Marchese L, Faravelli G, Obici L, Hawkins PN, Taylor GW, Gillmore JD, Pepys MB, Bellotti V.

J Biol Chem. 2018 Sep 14;293(37):14192-14199. doi: 10.1074/jbc.RA118.003990. Epub 2018 Jul 17.

6.

Interference of citrate-stabilized gold nanoparticles with β2-microglobulin oligomeric association.

Cantarutti C, Raj G, Fogolari F, Giorgetti S, Corazza A, Bellotti V, Naumov P, Esposito G.

Chem Commun (Camb). 2018 May 24;54(43):5422-5425. doi: 10.1039/c8cc01053f.

PMID:
29737327
7.

Oleuropein aglycone: A polyphenol with different targets against amyloid toxicity.

Leri M, Oropesa-Nuñez R, Canale C, Raimondi S, Giorgetti S, Bruzzone E, Bellotti V, Stefani M, Bucciantini M.

Biochim Biophys Acta Gen Subj. 2018 Jun;1862(6):1432-1442. doi: 10.1016/j.bbagen.2018.03.023. Epub 2018 Mar 21.

PMID:
29571746
8.

Misidentification of transthyretin and immunoglobulin variants by proteomics due to methyl lysine formation in formalin-fixed paraffin-embedded amyloid tissue.

Canetti D, Rendell NB, Di Vagno L, Gilbertson JA, Rowczenio D, Rezk T, Gillmore JD, Hawkins PN, Verona G, Mangione PP, Giorgetti S, Mauri P, Motta S, De Palma A, Bellotti V, Taylor GW.

Amyloid. 2017 Dec;24(4):233-241. doi: 10.1080/13506129.2017.1385452. Epub 2017 Oct 10.

PMID:
29016222
9.

Increasing the accuracy of proteomic typing by decellularisation of amyloid tissue biopsies.

Mangione PP, Mazza G, Gilbertson JA, Rendell NB, Canetti D, Giorgetti S, Frenguelli L, Curti M, Rezk T, Raimondi S, Pepys MB, Hawkins PN, Gillmore JD, Taylor GW, Pinzani M, Bellotti V.

J Proteomics. 2017 Aug 8;165:113-118. doi: 10.1016/j.jprot.2017.06.016. Epub 2017 Jun 21.

10.

A specific nanobody prevents amyloidogenesis of D76N β2-microglobulin in vitro and modifies its tissue distribution in vivo.

Raimondi S, Porcari R, Mangione PP, Verona G, Marcoux J, Giorgetti S, Taylor GW, Ellmerich S, Ballico M, Zanini S, Pardon E, Al-Shawi R, Simons JP, Corazza A, Fogolari F, Leri M, Stefani M, Bucciantini M, Gillmore JD, Hawkins PN, Valli M, Stoppini M, Robinson CV, Steyaert J, Esposito G, Bellotti V.

Sci Rep. 2017 Apr 21;7:46711. doi: 10.1038/srep46711.

11.

Inhibition of the mechano-enzymatic amyloidogenesis of transthyretin: role of ligand affinity, binding cooperativity and occupancy of the inner channel.

Verona G, Mangione PP, Raimondi S, Giorgetti S, Faravelli G, Porcari R, Corazza A, Gillmore JD, Hawkins PN, Pepys MB, Taylor GW, Bellotti V.

Sci Rep. 2017 Mar 15;7(1):182. doi: 10.1038/s41598-017-00338-x.

12.

Citrate-stabilized gold nanoparticles hinder fibrillogenesis of a pathological variant of β2-microglobulin.

Cantarutti C, Raimondi S, Brancolini G, Corazza A, Giorgetti S, Ballico M, Zanini S, Palmisano G, Bertoncin P, Marchese L, Patrizia Mangione P, Bellotti V, Corni S, Fogolari F, Esposito G.

Nanoscale. 2017 Mar 17;9(11):3941-3951. doi: 10.1039/c6nr09362k.

PMID:
28265615
13.

De-immunized and Functional Therapeutic (DeFT) versions of a long lasting recombinant alpha interferon for antiviral therapy.

Mufarrege EF, Giorgetti S, Etcheverrigaray M, Terry F, Martin W, De Groot AS.

Clin Immunol. 2017 Mar;176:31-41. doi: 10.1016/j.clim.2017.01.003. Epub 2017 Jan 10.

PMID:
28089609
14.

Biochemical and Electrophysiological Modification of Amyloid Transthyretin on Cardiomyocytes.

Sartiani L, Bucciantini M, Spinelli V, Leri M, Natalello A, Nosi D, Maria Doglia S, Relini A, Penco A, Giorgetti S, Gerace E, Mannaioni G, Bellotti V, Rigacci S, Cerbai E, Stefani M.

Biophys J. 2016 Nov 1;111(9):2024-2038. doi: 10.1016/j.bpj.2016.09.010.

15.

In situ characterization of protein aggregates in human tissues affected by light chain amyloidosis: a FTIR microspectroscopy study.

Ami D, Lavatelli F, Rognoni P, Palladini G, Raimondi S, Giorgetti S, Monti L, Doglia SM, Natalello A, Merlini G.

Sci Rep. 2016 Jul 4;6:29096. doi: 10.1038/srep29096.

16.

Molecular insights into cell toxicity of a novel familial amyloidogenic variant of β2-microglobulin.

Leri M, Bemporad F, Oropesa-Nuñez R, Canale C, Calamai M, Nosi D, Ramazzotti M, Giorgetti S, Pavone FS, Bellotti V, Stefani M, Bucciantini M.

J Cell Mol Med. 2016 Aug;20(8):1443-56. doi: 10.1111/jcmm.12833. Epub 2016 Mar 18.

17.

Co-fibrillogenesis of Wild-type and D76N β2-Microglobulin: THE CRUCIAL ROLE OF FIBRILLAR SEEDS.

Natalello A, Mangione PP, Giorgetti S, Porcari R, Marchese L, Zorzoli I, Relini A, Ami D, Faravelli G, Valli M, Stoppini M, Doglia SM, Bellotti V, Raimondi S.

J Biol Chem. 2016 Apr 29;291(18):9678-89. doi: 10.1074/jbc.M116.720573. Epub 2016 Feb 26.

18.

Amyloid persistence in decellularized liver: biochemical and histopathological characterization.

Mazza G, Simons JP, Al-Shawi R, Ellmerich S, Urbani L, Giorgetti S, Taylor GW, Gilbertson JA, Hall AR, Al-Akkad W, Dhar D, Hawkins PN, De Coppi P, Pinzani M, Bellotti V, Mangione PP.

Amyloid. 2016;23(1):1-7. doi: 10.3109/13506129.2015.1110518. Epub 2015 Dec 8.

19.

Decoding the Structural Bases of D76N ß2-Microglobulin High Amyloidogenicity through Crystallography and Asn-Scan Mutagenesis.

de Rosa M, Barbiroli A, Giorgetti S, Mangione PP, Bolognesi M, Ricagno S.

PLoS One. 2015 Dec 1;10(12):e0144061. doi: 10.1371/journal.pone.0144061. eCollection 2015.

20.

Enhanced toxicity of silver nanoparticles in transgenic Caenorhabditis elegans expressing amyloidogenic proteins.

Soria C, Coccini T, De Simone U, Marchese L, Zorzoli I, Giorgetti S, Raimondi S, Mangione PP, Ramat S, Bellotti V, Manzo L, Stoppini M.

Amyloid. 2015;22(4):221-8. doi: 10.3109/13506129.2015.1077216. Epub 2015 Oct 14.

PMID:
26466638

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