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Items: 14


Perturbation of Methionine/S-adenosylmethionine Metabolism as a Novel Vulnerability in MLL Rearranged Leukemia.

Barve A, Vega A, Shah PP, Ghare S, Casson L, Wunderlich M, Siskind LJ, Beverly LJ.

Cells. 2019 Oct 25;8(11). pii: E1322. doi: 10.3390/cells8111322.


Tributyrin Inhibits Ethanol-Induced Epigenetic Repression of CPT-1A and Attenuates Hepatic Steatosis and Injury.

Donde H, Ghare S, Joshi-Barve S, Zhang J, Vadhanam MV, Gobejishvili L, Lorkiewicz P, Srivastava S, McClain CJ, Barve S.

Cell Mol Gastroenterol Hepatol. 2019 Oct 22. pii: S2352-345X(19)30141-9. doi: 10.1016/j.jcmgh.2019.10.005. [Epub ahead of print]


Acrolein Is a Pathogenic Mediator of Alcoholic Liver Disease and the Scavenger Hydralazine Is Protective in Mice.

Chen WY, Zhang J, Ghare S, Barve S, McClain C, Joshi-Barve S.

Cell Mol Gastroenterol Hepatol. 2016 May 27;2(5):685-700. doi: 10.1016/j.jcmgh.2016.05.010. eCollection 2016 Sep.


Acrolein enhances epigenetic modifications, FasL expression and hepatocyte toxicity induced by anti-HIV drug Zidovudine.

Ghare SS, Donde H, Chen WY, Barker DF, Gobejishvilli L, McClain CJ, Barve SS, Joshi-Barve S.

Toxicol In Vitro. 2016 Sep;35:66-76. doi: 10.1016/j.tiv.2016.05.013. Epub 2016 May 26.


Misoprostol modulates cytokine expression through a cAMP pathway: Potential therapeutic implication for liver disease.

Gobejishvili L, Ghare S, Khan R, Cambon A, Barker DF, Barve S, McClain C, Hill D.

Clin Immunol. 2015 Dec;161(2):291-9. doi: 10.1016/j.clim.2015.09.008. Epub 2015 Sep 25.


Molecular mechanisms of acrolein toxicity: relevance to human disease.

Moghe A, Ghare S, Lamoreau B, Mohammad M, Barve S, McClain C, Joshi-Barve S.

Toxicol Sci. 2015 Feb;143(2):242-55. doi: 10.1093/toxsci/kfu233. Review.


Systemic cytokine and interferon responsiveness Patterns in HIV and HCV mono and co-infections.

Fernandez-Botran R, Joshi-Barve S, Ghare S, Barve S, Young M, Plankey M, Bordon J.

J Interferon Cytokine Res. 2014 Nov;34(11):885-93. doi: 10.1089/jir.2014.0006. Epub 2014 Jun 23.


Coordinated histone H3 methylation and acetylation regulate physiologic and pathologic fas ligand gene expression in human CD4+ T cells.

Ghare SS, Joshi-Barve S, Moghe A, Patil M, Barker DF, Gobejishvili L, Brock GN, Cave M, McClain CJ, Barve SS.

J Immunol. 2014 Jul 1;193(1):412-21. doi: 10.4049/jimmunol.1400055. Epub 2014 Jun 4.


Binge ethanol-induced HDAC3 down-regulates Cpt1α expression leading to hepatic steatosis and injury.

Kirpich I, Zhang J, Gobejishvili L, Kharebava G, Barker D, Ghare S, Joshi-Barve S, McClain CJ, Barve S.

Alcohol Clin Exp Res. 2013 Nov;37(11):1920-9. doi: 10.1111/acer.12172. Epub 2013 Jul 26.


Binge alcohol-induced microvesicular liver steatosis and injury are associated with down-regulation of hepatic Hdac 1, 7, 9, 10, 11 and up-regulation of Hdac 3.

Kirpich I, Ghare S, Zhang J, Gobejishvili L, Kharebava G, Barve SJ, Barker D, Moghe A, McClain CJ, Barve S.

Alcohol Clin Exp Res. 2012 Sep;36(9):1578-86. doi: 10.1111/j.1530-0277.2012.01751.x. Epub 2012 Feb 29.


Histone modifications and alcohol-induced liver disease: are altered nutrients the missing link?

Moghe A, Joshi-Barve S, Ghare S, Gobejishvili L, Kirpich I, McClain CJ, Barve S.

World J Gastroenterol. 2011 May 28;17(20):2465-72. doi: 10.3748/wjg.v17.i20.2465. Review.


Ethanol inhibits lipid raft-mediated TCR signaling and IL-2 expression: potential mechanism of alcohol-induced immune suppression.

Ghare S, Patil M, Hote P, Suttles J, McClain C, Barve S, Joshi-Barve S.

Alcohol Clin Exp Res. 2011 Aug;35(8):1435-44. doi: 10.1111/j.1530-0277.2011.01479.x. Epub 2011 Apr 4.


S-adenosylmethionine decreases lipopolysaccharide-induced phosphodiesterase 4B2 and attenuates tumor necrosis factor expression via cAMP/protein kinase A pathway.

Gobejishvili L, Avila DV, Barker DF, Ghare S, Henderson D, Brock GN, Kirpich IA, Joshi-Barve S, Mokshagundam SP, McClain CJ, Barve S.

J Pharmacol Exp Ther. 2011 May;337(2):433-43. doi: 10.1124/jpet.110.174268. Epub 2011 Jan 25.


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