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Items: 16

1.

5-Nitro-Thiophene-Thiosemicarbazone Derivatives Present Antitumor Activity Mediated by Apoptosis and DNA Intercalation.

Roque Marques KM, do Desterro MR, de Arruda SM, de-Araújo Neto LN, de Lima MDCA, de Almeida SMV, Silva ECDD, Aquino TM, Júnior EFDS, Júnior JXD, Silva MM, de A Dantas MD, C Santos JC, Figueiredo IM, Bazin MA, Marchand P, da Silva TG, Mendonça Junior FJB.

Curr Top Med Chem. 2019 Jun 21. doi: 10.2174/1568026619666190621120304. [Epub ahead of print]

PMID:
31223089
2.

Synthesis, DNA and protein interactions and human topoisomerase inhibition of novel Spiroacridine derivatives.

Gouveia RG, Ribeiro AG, Segundo MÂSP, de Oliveira JF, de Lima MDCA, de Lima Souza TRC, de Almeida SMV, de Moura RO.

Bioorg Med Chem. 2018 Dec 1;26(22):5911-5921. doi: 10.1016/j.bmc.2018.10.038. Epub 2018 Oct 29.

PMID:
30420325
3.

Spiro-acridine inhibiting tyrosinase enzyme: Kinetic, protein-ligand interaction and molecular docking studies.

Menezes TM, de Almeida SMV, de Moura RO, Seabra G, de Lima MDCA, Neves JL.

Int J Biol Macromol. 2019 Feb 1;122:289-297. doi: 10.1016/j.ijbiomac.2018.10.175. Epub 2018 Oct 26.

PMID:
30401647
4.

Synthesis, in vitro and in vivo biological evaluation, COX-1/2 inhibition and molecular docking study of indole-N-acylhydrazone derivatives.

Moraes ADTO, Miranda MDS, Jacob ÍTT, Amorim CADC, Moura RO, Silva SÂSD, Soares MBP, Almeida SMV, Souza TRCL, Oliveira JF, Silva TGD, Melo CML, Moreira DRM, Lima MDCA.

Bioorg Med Chem. 2018 Nov 1;26(20):5388-5396. doi: 10.1016/j.bmc.2018.07.024. Epub 2018 Jul 17.

PMID:
30293795
5.

Molecular profile of mannan-binding lectin in hepatitis C patients with MBL gene polymorphisms by a modified mannan-coated nitrocellulose assay.

Albuquerque DAP, Cavalcanti IT, Vasconcelos LRS, Montenegro F, Pereira LMMB, Cavalcanti MSM, Moura P, Júnior LBC, de Almeida SMV, Beltrão EIC.

J Immunol Methods. 2018 Sep;460:101-106. doi: 10.1016/j.jim.2018.06.015. Epub 2018 Jul 3.

PMID:
30056939
6.

Lectin-carbohydrate complex evaluation by chemiluminescence.

de Lima LRA, da Silva LPBG, de Almeida SMV, Cahú TB, Beltrão EIC, de Carvalho Júnior LB.

Anal Biochem. 2018 May 1;548:91-95. doi: 10.1016/j.ab.2018.01.024. Epub 2018 Feb 16.

PMID:
29458035
7.

New thiophene-acridine compounds: Synthesis, antileishmanial activity, DNA binding, chemometric, and molecular docking studies.

de Lima Serafim V, Félix MB, Frade Silva DK, Rodrigues KADF, Andrade PN, de Almeida SMV, de Albuquerque Dos Santos S, de Oliveira JF, de Lima MDCA, Mendonça-Junior FJB, Scotti MT, de Oliveira MR, de Moura RO.

Chem Biol Drug Des. 2018 Jun;91(6):1141-1155. doi: 10.1111/cbdd.13176. Epub 2018 Mar 25.

PMID:
29415325
8.

DNA binding and Topoisomerase inhibition: How can these mechanisms be explored to design more specific anticancer agents?

de Almeida SMV, Ribeiro AG, de Lima Silva GC, Ferreira Alves JE, Beltrão EIC, de Oliveira JF, de Carvalho LB Junior, Alves de Lima MDC.

Biomed Pharmacother. 2017 Dec;96:1538-1556. doi: 10.1016/j.biopha.2017.11.054. Epub 2017 Nov 22. Review.

PMID:
29174576
9.

Synthesis of novel indole derivatives as promising DNA-binding agents and evaluation of antitumor and antitopoisomerase I activities.

Lafayette EA, de Almeida SMV, Cavalcanti Santos RV, de Oliveira JF, Amorim CADC, da Silva RMF, Pitta MGDR, Pitta IDR, de Moura RO, de Carvalho Júnior LB, de Melo Rêgo MJB, de Lima MDCA.

Eur J Med Chem. 2017 Aug 18;136:511-522. doi: 10.1016/j.ejmech.2017.05.012. Epub 2017 May 4.

PMID:
28531811
10.

Thiosemicarbazones and 4-thiazolidinones indole-based derivatives: Synthesis, evaluation of antiproliferative activity, cell death mechanisms and topoisomerase inhibition assay.

de Oliveira JF, Lima TS, Vendramini-Costa DB, de Lacerda Pedrosa SCB, Lafayette EA, da Silva RMF, de Almeida SMV, de Moura RO, Ruiz ALTG, de Carvalho JE, de Lima MDCA.

Eur J Med Chem. 2017 Aug 18;136:305-314. doi: 10.1016/j.ejmech.2017.05.023. Epub 2017 May 8.

PMID:
28505535
11.

Ultrastructural Assessment of 2-(acridin-9-ylmethylene)-N-phenylhydrazinecarbothioamide activity on human breast adenocarcinoma cells.

de Almeida SMV, da Silva LPBG, de Lima LRA, Longato GB, Padilha RJR, Alves LC, Brayner FA, Ruiz ALTG, de Carvalho JE, Beltrão EIC, de Lima MDCA, de Carvalho Júnior LB.

Micron. 2016 Nov;90:114-122. doi: 10.1016/j.micron.2016.08.009. Epub 2016 Aug 30.

PMID:
27668344
12.

New spiro-acridines: DNA interaction, antiproliferative activity and inhibition of human DNA topoisomerases.

Almeida SM, Lafayette EA, Silva WL, Lima Serafim V, Menezes TM, Neves JL, Ruiz AL, Carvalho JE, Moura RO, Beltrão EI, Carvalho Júnior LB, Lima MD.

Int J Biol Macromol. 2016 Nov;92:467-475. doi: 10.1016/j.ijbiomac.2016.07.057. Epub 2016 Jul 18.

PMID:
27435006
13.

Synthesis, DNA Binding, and Antiproliferative Activity of Novel Acridine-Thiosemicarbazone Derivatives.

de Almeida SM, Lafayette EA, da Silva LP, Amorim CA, de Oliveira TB, Ruiz AL, de Carvalho JE, de Moura RO, Beltrão EI, de Lima Mdo C, de Carvalho Júnior LB.

Int J Mol Sci. 2015 Jun 9;16(6):13023-42. doi: 10.3390/ijms160613023.

14.

Different cell death responses induced by eupomatenoid-5 in MCF-7 and 786-0 tumor cell lines.

Longato GB, Fiorito GF, Vendramini-Costa DB, de Oliveira Sousa IM, Tinti SV, Ruiz AL, de Almeida SM, Padilha RJ, Foglio MA, de Carvalho JE.

Toxicol In Vitro. 2015 Aug;29(5):1026-33. doi: 10.1016/j.tiv.2015.04.002. Epub 2015 Apr 13.

PMID:
25882683
15.

Evaluation of glycophenotype in prostatic neoplasm by chemiluminescent assay.

da Silva LP, de Almeida SM, de Lima LR, Cavalcanti Cde L, de Melo Lira MM, da Silva Mda P, Beltrão EI, de Carvalho Júnior LB.

Int J Clin Exp Pathol. 2014 Jun 15;7(7):3800-8. eCollection 2014.

16.

Synthesis, DNA binding and topoisomerase I inhibition activity of thiazacridine and imidazacridine derivatives.

Lafayette EA, Vitalino de Almeida SM, Pitta MG, Carneiro Beltrão EI, da Silva TG, Olímpio de Moura R, Pitta Ida R, de Carvalho LB Jr, de Lima Mdo C.

Molecules. 2013 Dec 6;18(12):15035-50. doi: 10.3390/molecules181215035.

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