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J Dermatolog Treat. 2014 Feb;25(1):30-3. doi: 10.3109/09546634.2013.800182. Epub 2013 May 23.

Efficacy and maintenance strategies of two-compound formulation calcipotriol and betamethasone dipropionate gel (Xamiol® gel) in the treatment of scalp psoriasis: results from a study in 885 patients.

Author information

1
U.O.C. Dermatologia, University of Rome 'Tor Vergata' - PTV, Viale Oxford, 81, 00133 Rome , Italy.

Abstract

BACKGROUND:

Previous studies showed the efficacy of a formulation containing calcipotriol and betamethasone dipropionate for the treatment of psoriasis.

OBJECTIVE:

To investigate maintenance strategies of a formulation containing calcipotriol (50 µg/g) and betamethasone dipropionate (0.5 mg/g) for the treatment of scalp psoriasis.

MATERIALS AND METHODS:

Nine-hundred and four patients were screened and randomised on a 1:1 basis in two groups: maintenance of two applications per week (group A) versus on-demand therapy (group B). Clinical evaluation was performed at weeks 0, 2, 4, 8 and 12.

RESULTS:

Eight-hundred and eighty-five patients were randomised: 441 in group A and 444 in group B. From week 2, both groups showed a significant clinical improvement compared with baseline; at weeks 8 and 12, group A demonstrated a higher clinical response compared with group B (p < 0.05). This difference was statistically significant (OR 0.47, 95% CI 0.37, 0.60).

CONCLUSIONS:

The maintenance of twice-weekly application versus on-demand treatment of calcipotriol/betamethasone dipropionate gel is more effective and is associated with a lower rate of relapse.

PMID:
23621170
DOI:
10.3109/09546634.2013.800182
[Indexed for MEDLINE]

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