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Items: 1 to 20 of 35

1.

Design, synthesis and biological evaluation of novel TRĪ² selective agonists sustained by ADME-toxicity analysis.

Runfola M, Sestito S, Bellusci L, La Pietra V, D'Amore VM, Kowalik MA, Chiellini G, Gul S, Perra A, Columbano A, Marinelli L, Novellino E, Rapposelli S.

Eur J Med Chem. 2019 Dec 23;188:112006. doi: 10.1016/j.ejmech.2019.112006. [Epub ahead of print]

PMID:
31931337
2.

Dual PDK1/Aurora Kinase A Inhibitors Reduce Pancreatic Cancer Cell Proliferation and Colony Formation.

Casari I, Domenichini A, Sestito S, Capone E, Sala G, Rapposelli S, Falasca M.

Cancers (Basel). 2019 Oct 31;11(11). pii: E1695. doi: 10.3390/cancers11111695.

3.

Design and synthesis of H2S-donor hybrids: A new treatment for Alzheimer's disease?

Sestito S, Pruccoli L, Runfola M, Citi V, Martelli A, Saccomanni G, Calderone V, Tarozzi A, Rapposelli S.

Eur J Med Chem. 2019 Dec 15;184:111745. doi: 10.1016/j.ejmech.2019.111745. Epub 2019 Sep 27.

PMID:
31585237
4.

A 46,XY Female with a 9p24.3p24.1 Deletion and a 8q24.11q24.3 Duplication: A Case Report and Review of the Literature.

Bruni V, Roppa K, Scionti F, Apa R, Sestito S, Di Martino MT, Pensabene L, Concolino D.

Cytogenet Genome Res. 2019;158(2):74-82. doi: 10.1159/000500619. Epub 2019 May 28. Review.

PMID:
31141803
5.

Preclinical validation of 3-phosphoinositide-dependent protein kinase 1 inhibition in pancreatic cancer.

Emmanouilidi A, Fyffe CA, Ferro R, Edling CE, Capone E, Sestito S, Rapposelli S, Lattanzio R, Iacobelli S, Sala G, Maffucci T, Falasca M.

J Exp Clin Cancer Res. 2019 May 14;38(1):191. doi: 10.1186/s13046-019-1191-2.

6.

Multi-targeted ChEI-copper chelating molecules as neuroprotective agents.

Sestito S, Wang S, Chen Q, Lu J, Bertini S, Pomelli C, Chiellini G, He X, Pi R, Rapposelli S.

Eur J Med Chem. 2019 Jul 15;174:216-225. doi: 10.1016/j.ejmech.2019.04.060. Epub 2019 Apr 23.

PMID:
31042617
7.

A patent update on PDK1 inhibitors (2015-present).

Sestito S, Rapposelli S.

Expert Opin Ther Pat. 2019 Apr;29(4):271-282. doi: 10.1080/13543776.2019.1597852. Epub 2019 Mar 29. Review.

PMID:
30897008
8.

Memantine prodrug as a new agent for Alzheimer's Disease.

Sestito S, Daniele S, Pietrobono D, Citi V, Bellusci L, Chiellini G, Calderone V, Martini C, Rapposelli S.

Sci Rep. 2019 Mar 15;9(1):4612. doi: 10.1038/s41598-019-40925-8.

9.

Epibatidine: A Promising Natural Alkaloid in Health.

Salehi B, Sestito S, Rapposelli S, Peron G, Calina D, Sharifi-Rad M, Sharopov F, Martins N, Sharifi-Rad J.

Biomolecules. 2018 Dec 23;9(1). pii: E6. doi: 10.3390/biom9010006. Review.

10.

New Multitarget Approaches in the War Against Glioblastoma: A Mini-Perspective.

Sestito S, Runfola M, Tonelli M, Chiellini G, Rapposelli S.

Front Pharmacol. 2018 Aug 3;9:874. doi: 10.3389/fphar.2018.00874. eCollection 2018.

11.

Werner syndrome: a rare mutation.

Castagna A, Gareri P, Falvo F, Sestito S, Rocca M, Pensabene L, Concolino D, Coppolino G, Ruotolo G.

Aging Clin Exp Res. 2019 Mar;31(3):425-429. doi: 10.1007/s40520-018-0982-1. Epub 2018 Jun 6. No abstract available.

PMID:
29876830
12.

Assessment of intrafamilial clinical variability of poikiloderma with neutropenia by a 10-year follow-up of three affected siblings.

Concolino D, Sestito S, Falvo F, Romano G, Ceravolo M, Anastasio E, Pensabene L, Colombo EA, Larizza L.

Eur J Med Genet. 2019 Jan;62(1):73-76. doi: 10.1016/j.ejmg.2018.05.007. Epub 2018 May 24.

PMID:
29753917
13.

New Insights into the Potential Roles of 3-Iodothyronamine (T1AM) and Newly Developed Thyronamine-Like TAAR1 Agonists in Neuroprotection.

Bellusci L, Laurino A, Sabatini M, Sestito S, Lenzi P, Raimondi L, Rapposelli S, Biagioni F, Fornai F, Salvetti A, Rossi L, Zucchi R, Chiellini G.

Front Pharmacol. 2017 Dec 12;8:905. doi: 10.3389/fphar.2017.00905. eCollection 2017.

14.

Genetic variants associated with Fabry disease progression despite enzyme replacement therapy.

Scionti F, Di Martino MT, Sestito S, Nicoletti A, Falvo F, Roppa K, Arbitrio M, Guzzi PH, Agapito G, Pisani A, Riccio E, Concolino D, Pensabene L.

Oncotarget. 2017 Nov 18;8(64):107558-107564. doi: 10.18632/oncotarget.22505. eCollection 2017 Dec 8.

15.

Nature-based molecules combined with rivastigmine: A symbiotic approach for the synthesis of new agents against Alzheimer's disease.

Nesi G, Chen Q, Sestito S, Digiacomo M, Yang X, Wang S, Pi R, Rapposelli S.

Eur J Med Chem. 2017 Dec 1;141:232-239. doi: 10.1016/j.ejmech.2017.10.006. Epub 2017 Oct 4.

PMID:
29031070
16.

Hydrogen Sulfide: A Worthwhile Tool in the Design of New Multitarget Drugs.

Sestito S, Nesi G, Pi R, Macchia M, Rapposelli S.

Front Chem. 2017 Sep 27;5:72. doi: 10.3389/fchem.2017.00072. eCollection 2017.

17.

Oxidative Stress, Mitochondrial Abnormalities and Proteins Deposition: Multitarget Approaches in Alzheimer's Disease.

Nesi G, Sestito S, Digiacomo M, Rapposelli S.

Curr Top Med Chem. 2017;17(27):3062-3079. doi: 10.2174/1568026617666170607114232. Review.

PMID:
28595557
18.

Synthesis and Functional Evaluation of Novel Aldose Reductase Inhibitors Bearing a Spirobenzopyran Scaffold.

Digiacomo M, Sartini S, Nesi G, Sestito S, Coviello V, La Motta C, Rapposelli S.

Open Med Chem J. 2017 Jan 31;11:9-23. doi: 10.2174/1874104501711010009. eCollection 2017.

19.

Parapelvic cysts, a distinguishing feature of renal Fabry disease.

Pisani A, Petruzzelli Annicchiarico L, Pellegrino A, Bruzzese D, Feriozzi S, Imbriaco M, Tedeschi E, Cocozza S, De Rosa D, Mignani R, Veroux M, Battaglia Y, Concolino D, Sestito S, Pieruzzi F, Caroti L, Manna R, Zizzo C, Santangelo M, Sabbatini M, Riccio E.

Nephrol Dial Transplant. 2018 Feb 1;33(2):318-323. doi: 10.1093/ndt/gfx009.

PMID:
28371803
20.

Combination therapy in a patient with chronic neuronopathic Gaucher disease: a case report.

Ceravolo F, Grisolia M, Sestito S, Falvo F, Moricca MT, Concolino D.

J Med Case Rep. 2017 Jan 20;11(1):19. doi: 10.1186/s13256-016-1147-5.

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