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Items: 11


International standards for monoclonal antibodies to support pre- and post-marketing product consistency: Evaluation of a candidate international standard for the bioactivities of rituximab.

Prior S, Hufton SE, Fox B, Dougall T, Rigsby P, Bristow A; participants of the study.

MAbs. 2018 Jan;10(1):129-142. doi: 10.1080/19420862.2017.1386824. Epub 2017 Nov 3.


Cross-Neutralising Nanobodies Bind to a Conserved Pocket in the Hemagglutinin Stem Region Identified Using Yeast Display and Deep Mutational Scanning.

Gaiotto T, Hufton SE.

PLoS One. 2016 Oct 14;11(10):e0164296. doi: 10.1371/journal.pone.0164296. eCollection 2016.


The breadth of cross sub-type neutralisation activity of a single domain antibody to influenza hemagglutinin can be increased by antibody valency.

Hufton SE, Risley P, Ball CR, Major D, Engelhardt OG, Poole S.

PLoS One. 2014 Aug 1;9(8):e103294. doi: 10.1371/journal.pone.0103294. eCollection 2014.


Affinity maturation and functional dissection of a humanised anti-RAGE monoclonal antibody by ribosome display.

Hufton SE.

Methods Mol Biol. 2012;805:403-22. doi: 10.1007/978-1-61779-379-0_23.


Affinity maturation of a humanized rat antibody for anti-RAGE therapy: comprehensive mutagenesis reveals a high level of mutational plasticity both inside and outside the complementarity-determining regions.

Finlay WJ, Cunningham O, Lambert MA, Darmanin-Sheehan A, Liu X, Fennell BJ, Mahon CM, Cummins E, Wade JM, O'Sullivan CM, Tan XY, Piche N, Pittman DD, Paulsen J, Tchistiakova L, Kodangattil S, Gill D, Hufton SE.

J Mol Biol. 2009 May 8;388(3):541-58. doi: 10.1016/j.jmb.2009.03.019. Epub 2009 Mar 13.


Identification and characterization of ErbB-3-binding protein-1 as a target for immunotherapy.

Santegoets SJ, Schreurs MW, Reurs AW, Lindenberg JJ, Kueter EW, van den Eertwegh AJ, Hooijberg E, Brandwijk RJ, Hufton SE, Hoogenboom HR, Scheper RJ, Somers VA, de Gruijl TD.

J Immunol. 2007 Aug 1;179(3):2005-12.


Generation of high-affinity human antibodies by combining donor-derived and synthetic complementarity-determining-region diversity.

Hoet RM, Cohen EH, Kent RB, Rookey K, Schoonbroodt S, Hogan S, Rem L, Frans N, Daukandt M, Pieters H, van Hegelsom R, Neer NC, Nastri HG, Rondon IJ, Leeds JA, Hufton SE, Huang L, Kashin I, Devlin M, Kuang G, Steukers M, Viswanathan M, Nixon AE, Sexton DJ, Hoogenboom HR, Ladner RC.

Nat Biotechnol. 2005 Mar;23(3):344-8. Epub 2005 Feb 20.


Construction and diversification of yeast cell surface displayed libraries by yeast mating: application to the affinity maturation of Fab antibody fragments.

Blaise L, Wehnert A, Steukers MP, van den Beucken T, Hoogenboom HR, Hufton SE.

Gene. 2004 Nov 24;342(2):211-8.


Affinity maturation of Fab antibody fragments by fluorescent-activated cell sorting of yeast-displayed libraries.

van den Beucken T, Pieters H, Steukers M, van der Vaart M, Ladner RC, Hoogenboom HR, Hufton SE.

FEBS Lett. 2003 Jul 10;546(2-3):288-94.


Target validation for genomics using peptide-specific phage antibodies: a study of five gene products overexpressed in colorectal cancer.

Van Beijnum JR, Moerkerk PT, Gerbers AJ, De Bruïne AP, Arends JW, Hoogenboom HR, Hufton SE.

Int J Cancer. 2002 Sep 10;101(2):118-27.


A panel of candidate tumor antigens in colorectal cancer revealed by the serological selection of a phage displayed cDNA expression library.

Somers VA, Brandwijk RJ, Joosten B, Moerkerk PT, Arends JW, Menheere P, Pieterse WO, Claessen A, Scheper RJ, Hoogenboom HR, Hufton SE.

J Immunol. 2002 Sep 1;169(5):2772-80.

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