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Items: 1 to 20 of 26

1.

Synthesis, Docking and Biological Evaluation of a Novel Class of Imidazothiazoles as IDO1 Inhibitors.

Serafini M, Torre E, Aprile S, Massarotti A, Fallarini S, Pirali T.

Molecules. 2019 May 15;24(10). pii: E1874. doi: 10.3390/molecules24101874.

2.

Inhalation of the prodrug PI3K inhibitor CL27c improves lung function in asthma and fibrosis.

Campa CC, Silva RL, Margaria JP, Pirali T, Mattos MS, Kraemer LR, Reis DC, Grosa G, Copperi F, Dalmarco EM, Lima-Júnior RCP, Aprile S, Sala V, Dal Bello F, Prado DS, Alves-Filho JC, Medana C, Cassali GD, Tron GC, Teixeira MM, Ciraolo E, Russo RC, Hirsch E.

Nat Commun. 2018 Dec 12;9(1):5232. doi: 10.1038/s41467-018-07698-6.

3.

Pyrtriazoles, a Novel Class of Store-Operated Calcium Entry Modulators: Discovery, Biological Profiling, and in Vivo Proof-of-Concept Efficacy in Acute Pancreatitis.

Riva B, Griglio A, Serafini M, Cordero-Sanchez C, Aprile S, Di Paola R, Gugliandolo E, Alansary D, Biocotino I, Lim D, Grosa G, Galli U, Niemeyer B, Sorba G, Canonico PL, Cuzzocrea S, Genazzani AA, Pirali T.

J Med Chem. 2018 Nov 8;61(21):9756-9783. doi: 10.1021/acs.jmedchem.8b01512. Epub 2018 Oct 30.

PMID:
30347159
4.

Targeting Transient Receptor Potential Vanilloid 1 (TRPV1) Channel Softly: The Discovery of Passerini Adducts as a Topical Treatment for Inflammatory Skin Disorders.

Serafini M, Griglio A, Aprile S, Seiti F, Travelli C, Pattarino F, Grosa G, Sorba G, Genazzani AA, Gonzalez-Rodriguez S, Butron L, Devesa I, Fernandez-Carvajal A, Pirali T, Ferrer-Montiel A.

J Med Chem. 2018 May 24;61(10):4436-4455. doi: 10.1021/acs.jmedchem.8b00109. Epub 2018 May 15.

PMID:
29722529
5.

Troxerutin, a mixture of O-hydroxyethyl derivatives of the natural flavonoid rutin: Chemical stability and analytical aspects.

Bianchi M, Canavesi R, Aprile S, Grosa G, Del Grosso E.

J Pharm Biomed Anal. 2018 Feb 20;150:248-257. doi: 10.1016/j.jpba.2017.12.018. Epub 2017 Dec 9.

PMID:
29258044
6.

Biological effects of combined resveratrol and vitamin D3 on ovarian tissue.

Uberti F, Morsanuto V, Aprile S, Ghirlanda S, Stoppa I, Cochis A, Grosa G, Rimondini L, Molinari C.

J Ovarian Res. 2017 Sep 15;10(1):61. doi: 10.1186/s13048-017-0357-9.

7.

Identification of a Potent Phosphoinositide 3-Kinase Pan Inhibitor Displaying a Strategic Carboxylic Acid Group and Development of Its Prodrugs.

Pirali T, Ciraolo E, Aprile S, Massarotti A, Berndt A, Griglio A, Serafini M, Mercalli V, Landoni C, Campa CC, Margaria JP, Silva RL, Grosa G, Sorba G, Williams R, Hirsch E, Tron GC.

ChemMedChem. 2017 Sep 21;12(18):1542-1554. doi: 10.1002/cmdc.201700340. Epub 2017 Aug 31.

8.

An aryne-based three-component access to α-aroylamino amides.

Serafini M, Griglio A, Viarengo S, Aprile S, Pirali T.

Org Biomol Chem. 2017 Aug 9;15(31):6604-6612. doi: 10.1039/c7ob01715d.

PMID:
28752162
9.

New insights in the metabolism of oxybutynin: evidence of N-oxidation of propargylamine moiety and rearrangement to enaminoketone.

Aprile S, Canavesi R, Matucci R, Bellucci C, Del Grosso E, Grosa G.

Xenobiotica. 2018 May;48(5):478-487. doi: 10.1080/00498254.2017.1342288. Epub 2017 Jul 6.

PMID:
28608746
10.

Identification of Novel Triazole-Based Nicotinamide Phosphoribosyltransferase (NAMPT) Inhibitors Endowed with Antiproliferative and Antiinflammatory Activity.

Travelli C, Aprile S, Rahimian R, Grolla AA, Rogati F, Bertolotti M, Malagnino F, di Paola R, Impellizzeri D, Fusco R, Mercalli V, Massarotti A, Stortini G, Terrazzino S, Del Grosso E, Fakhfouri G, Troiani MP, Alisi MA, Grosa G, Sorba G, Canonico PL, Orsomando G, Cuzzocrea S, Genazzani AA, Galli U, Tron GC.

J Med Chem. 2017 Mar 9;60(5):1768-1792. doi: 10.1021/acs.jmedchem.6b01392. Epub 2017 Feb 22.

PMID:
28165742
11.

Development and validation of a stability-indicating HPLC-UV method for the determination of Thiocolchicoside and its degradation products.

Aprile S, Canavesi R, Bianchi M, Grosa G, Del Grosso E.

J Pharm Biomed Anal. 2017 Jan 5;132:66-71. doi: 10.1016/j.jpba.2016.09.037. Epub 2016 Sep 26.

PMID:
27697571
12.

Transition-Metal-Free Synthesis of 2-Arylimidazolones via Cascade Reaction between Arynes and α,α'-Disubstituted α-Isocyanoacetamides.

Gesù A, Pozzoli C, Torre E, Aprile S, Pirali T.

Org Lett. 2016 May 6;18(9):1992-5. doi: 10.1021/acs.orglett.6b00580. Epub 2016 Apr 8.

PMID:
27057924
13.

New insights in oxybutynin chemical stability: Identification in transdermal patches of a new impurity arising from oxybutynin N-oxide rearrangement.

Canavesi R, Aprile S, Giovenzana GB, Di Sotto A, Di Giacomo S, Del Grosso E, Grosa G.

Eur J Pharm Sci. 2016 Mar 10;84:123-31. doi: 10.1016/j.ejps.2016.01.015. Epub 2016 Jan 18.

PMID:
26796144
14.

Design, synthesis, and biological evaluation of combretabenzodiazepines: a novel class of anti-tubulin agents.

Galli U, Travelli C, Aprile S, Arrigoni E, Torretta S, Grosa G, Massarotti A, Sorba G, Canonico PL, Genazzani AA, Tron GC.

J Med Chem. 2015 Feb 12;58(3):1345-57. doi: 10.1021/jm5016389. Epub 2015 Jan 27.

PMID:
25584687
15.

Are 1,4- and 1,5-disubstituted 1,2,3-triazoles good pharmacophoric groups?

Massarotti A, Aprile S, Mercalli V, Del Grosso E, Grosa G, Sorba G, Tron GC.

ChemMedChem. 2014 Nov;9(11):2497-508. doi: 10.1002/cmdc.201402233. Epub 2014 Jul 30.

PMID:
25079879
16.

Development and validation of a stability-indicating LC-UV method for the determination of pantethine and its degradation product based on a forced degradation study.

Canavesi R, Aprile S, Varese E, Grosa G.

J Pharm Biomed Anal. 2014 Aug;97:141-50. doi: 10.1016/j.jpba.2014.04.025. Epub 2014 May 2.

PMID:
24863372
17.

Metabolic fate of combretastatin A-1: LC-DAD-MS/MS investigation and biological evaluation of its reactive metabolites.

Aprile S, Zaninetti R, Del Grosso E, Genazzani AA, Grosa G.

J Pharm Biomed Anal. 2013 May 5;78-79:233-42. doi: 10.1016/j.jpba.2013.02.030. Epub 2013 Feb 27.

PMID:
23501444
18.

A concise synthesis of pyrazole analogues of combretastatin A1 as potent anti-tubulin agents.

Zaninetti R, Cortese SV, Aprile S, Massarotti A, Canonico PL, Sorba G, Grosa G, Genazzani AA, Pirali T.

ChemMedChem. 2013 Apr;8(4):633-43. doi: 10.1002/cmdc.201200561. Epub 2013 Feb 21.

PMID:
23436706
19.

In vitro metabolic fate of alizapride: evidence for the formation of reactive metabolites based on liquid chromatography-tandem mass spectrometry.

Aprile S, Del Grosso E, Grosa G.

J Mass Spectrom. 2012 Jun;47(6):737-50. doi: 10.1002/jms.3011.

PMID:
22707166
20.

Forced degradation study of thiocolchicoside: characterization of its degradation products.

Erika del G, Silvio A, Giorgio G.

J Pharm Biomed Anal. 2012 Mar 5;61:215-23. doi: 10.1016/j.jpba.2011.12.008. Epub 2011 Dec 17.

PMID:
22226415

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