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Nutrients. 2017 Dec 1;9(12). pii: E1306. doi: 10.3390/nu9121306.

Resveratrol Role in Autoimmune Disease-A Mini-Review.

Author information

1
Pharmaceutical Science Post-Graduation Program, Neuroscience and Cellular Biology Post Graduation Program, Faculty of Pharmacy, Federal University of Pará, Avenue Augusto Correa SN, Guamá, Pará 66075-110, Brazil. any_015_@hotmail.com.
2
School of Pharmacy, Health Science Institute, Federal University of Pará/UFPA, Avenue Augusto Correa SN, Guamá, Pará 66075-110, Brazil. valterv@live.com.
3
Pharmaceutical Science Post-Graduation Program, Neuroscience and Cellular Biology Post Graduation Program, Faculty of Pharmacy, Federal University of Pará, Avenue Augusto Correa SN, Guamá, Pará 66075-110, Brazil. kcnavegantes@gmail.com.
4
School of Pharmacy, Health Science Institute, Federal University of Pará/UFPA, Avenue Augusto Correa SN, Guamá, Pará 66075-110, Brazil. jordanoreis@outlook.com.
5
Pharmaceutical Science Post-Graduation Program, Neuroscience and Cellular Biology Post Graduation Program, Faculty of Pharmacy, Federal University of Pará, Avenue Augusto Correa SN, Guamá, Pará 66075-110, Brazil. rafaelli_gomes@hotmail.com.
6
School of Pharmacy, Health Science Institute, Federal University of Pará/UFPA, Avenue Augusto Correa SN, Guamá, Pará 66075-110, Brazil. davilavrodrigues@gmail.com.
7
School of Pharmacy, Health Science Institute, Federal University of Pará/UFPA, Avenue Augusto Correa SN, Guamá, Pará 66075-110, Brazil. leticiagaspar.farma@hotmail.com.
8
Pharmaceutical Science Post-Graduation Program, Neuroscience and Cellular Biology Post Graduation Program, Faculty of Pharmacy, Federal University of Pará, Avenue Augusto Correa SN, Guamá, Pará 66075-110, Brazil. martachagas2@yahoo.com.br.

Abstract

Autoimmune diseases are still considered to be pressing concerns due the fact that they are leaders in death and disability causes worldwide. Resveratrol is a polyphenol derived from a variety of foods and beverages, including red grapes and red wine. Anti-inflammatory, antioxidant, and antiaging properties of resveratrol have been reported, and in some animal and human studies this compound reduced and ameliorated the progression of autoimmune diseases, such as rheumatoid arthritis, systemic lupus erythematosus, psoriasis, inflammatory bowel disease, and type 1 diabetes mellitus. Thus, this review aims to summarize and critically analyze the role of resveratrol in the modulation of several organ-specific or systemic autoimmune diseases.

KEYWORDS:

autoimmunity; inflammation; organ-specific; resveratrol; systemic

PMID:
29194364
PMCID:
PMC5748756
DOI:
10.3390/nu9121306
[Indexed for MEDLINE]
Free PMC Article

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