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Sensors (Basel). 2019 Jun 17;19(12). pii: E2713. doi: 10.3390/s19122713.

Investigation of Polyurethane Matrix Membranes for Salivary Nitrate ISFETs to Prevent the Drift.

Author information

1
Aist-Osaka University Advanced Photonics and Biosensing Open Innovation Laboratory, AIST, Suita 565-0043, Japan. osaki@ap.eng.osaka-u.ac.jp.
2
Department of Applied Physics, Graduate School of Engineering, Osaka University, Suita 565-0043, Japan. osaki@ap.eng.osaka-u.ac.jp.
3
Aist-Osaka University Advanced Photonics and Biosensing Open Innovation Laboratory, AIST, Suita 565-0043, Japan. m1m18505@st.oit.ac.jp.
4
Department of Applied Chemistry, Graduate School of Engineering, Osaka Institute of Technology, Osaka 535-8585, Japan. m1m18505@st.oit.ac.jp.
5
Department of Applied Chemistry, Graduate School of Engineering, Osaka Institute of Technology, Osaka 535-8585, Japan. takayo.moriuchi@oit.ac.jp.
6
National Institute of Technology, Toba College, Toba 517-8501, Japan. kitamura-k@toba-cmt.ac.jp.
7
Aist-Osaka University Advanced Photonics and Biosensing Open Innovation Laboratory, AIST, Suita 565-0043, Japan. s.wakida@aist.go.jp.
8
Department of Applied Physics, Graduate School of Engineering, Osaka University, Suita 565-0043, Japan. s.wakida@aist.go.jp.

Abstract

We have investigated human-stress monitoring by making use of salivary nitrate, which can be a candidate for stress markers, with ion-selective field-effect transistors (ISFETs). ISFETs are suitable for on-site single-drop analysis of salivary nitrate within 10 s. However, when ISFETs are used for salivary nitrate, ISFETs have a problem that is called the initial drift. The initial drift makes accurate nitrate monitoring difficult. Thus, the purpose of this study is to prevent the initial drift and to search for a new, simple polymer to possess a better performance of sensor responses than conventional matrix membranes, such as PVC. In this research, we investigated ISFETs using specific matrix membranes, for example KP-13, Pellethane®--, and P7281-PU. The initial drift was evaluated from the fluctuations of the response values generated by the ISFETs when immersed in saliva or aqueous solution. As a result, P7281-PU showed a prevention effect on the initial drift, both in the whole saliva and in various solutions. Furthermore, the cause of drift may be H+ diffusion, and the drift prevention effect of P7281-PU may be affected by urethane bond capturing H+ in the ion-selective membrane. This result suggests that a continuous nitrate monitoring is feasible and may be applied to wearable sensors.

KEYWORDS:

ISE; ISFETs; drift; ion-selective membrane; polyurethane; salivary nitrate; stress

PMID:
31212895
PMCID:
PMC6630929
DOI:
10.3390/s19122713
[Indexed for MEDLINE]
Free PMC Article

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