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Items: 1 to 20 of 198

1.

Correlation of homologous recombination deficiency induced mutational signatures with sensitivity to PARP inhibitors and cytotoxic agents.

Póti Á, Gyergyák H, Németh E, Rusz O, Tóth S, Kovácsházi C, Chen D, Szikriszt B, Spisák S, Takeda S, Szakács G, Szallasi Z, Richardson AL, Szüts D.

Genome Biol. 2019 Nov 14;20(1):240. doi: 10.1186/s13059-019-1867-0.

2.

Type II DNA Topoisomerases Cause Spontaneous Double-Strand Breaks in Genomic DNA.

Morimoto S, Tsuda M, Bunch H, Sasanuma H, Austin C, Takeda S.

Genes (Basel). 2019 Oct 30;10(11). pii: E868. doi: 10.3390/genes10110868. Review.

3.

Processing of a single ribonucleotide embedded into DNA by human nucleotide excision repair and DNA polymerase η.

Sassa A, Tada H, Takeishi A, Harada K, Suzuki M, Tsuda M, Sasanuma H, Takeda S, Sugasawa K, Yasui M, Honma M, Ura K.

Sci Rep. 2019 Sep 26;9(1):13910. doi: 10.1038/s41598-019-50421-8.

4.

Applicability Domain of Active Learning in Chemical Probe Identification: Convergence in Learning from Non-Specific Compounds and Decision Rule Clarification.

Polash AH, Nakano T, Takeda S, Brown JB.

Molecules. 2019 Jul 26;24(15). pii: E2716. doi: 10.3390/molecules24152716.

5.

Spatial Chromosome Folding and Active Transcription Drive DNA Fragility and Formation of Oncogenic MLL Translocations.

Gothe HJ, Bouwman BAM, Gusmao EG, Piccinno R, Petrosino G, Sayols S, Drechsel O, Minneker V, Josipovic N, Mizi A, Nielsen CF, Wagner EM, Takeda S, Sasanuma H, Hudson DF, Kindler T, Baranello L, Papantonis A, Crosetto N, Roukos V.

Mol Cell. 2019 Jul 25;75(2):267-283.e12. doi: 10.1016/j.molcel.2019.05.015. Epub 2019 Jun 12.

PMID:
31202576
6.

Brca1 is involved in tolerance to adefovir dipivoxil‑induced DNA damage.

Liu H, Wu Y, He F, Cheng Z, Zhao Z, Xiang C, Feng X, Bai X, Takeda S, Wu X, Qing Y.

Int J Mol Med. 2019 Jun;43(6):2491-2498. doi: 10.3892/ijmm.2019.4164. Epub 2019 Apr 11.

PMID:
31017265
7.

A screening for DNA damage response molecules that affect HIV-1 infection.

Yoshinaga N, Shindo K, Matsui Y, Takiuchi Y, Fukuda H, Nagata K, Shirakawa K, Kobayashi M, Takeda S, Takaori-Kondo A.

Biochem Biophys Res Commun. 2019 May 21;513(1):93-98. doi: 10.1016/j.bbrc.2019.03.168. Epub 2019 Mar 30.

PMID:
30935695
8.

PDIP38/PolDIP2 controls the DNA damage tolerance pathways by increasing the relative usage of translesion DNA synthesis over template switching.

Tsuda M, Ogawa S, Ooka M, Kobayashi K, Hirota K, Wakasugi M, Matsunaga T, Sakuma T, Yamamoto T, Chikuma S, Sasanuma H, Debatisse M, Doherty AJ, Fuchs RP, Takeda S.

PLoS One. 2019 Mar 6;14(3):e0213383. doi: 10.1371/journal.pone.0213383. eCollection 2019.

9.

BRCA1 Haploinsufficiency Is Masked by RNF168-Mediated Chromatin Ubiquitylation.

Zong D, Adam S, Wang Y, Sasanuma H, Callén E, Murga M, Day A, Kruhlak MJ, Wong N, Munro M, Ray Chaudhuri A, Karim B, Xia B, Takeda S, Johnson N, Durocher D, Nussenzweig A.

Mol Cell. 2019 Mar 21;73(6):1267-1281.e7. doi: 10.1016/j.molcel.2018.12.010. Epub 2019 Jan 28.

PMID:
30704900
10.

SUMOylation of PCNA by PIAS1 and PIAS4 promotes template switch in the chicken and human B cell lines.

Mohiuddin M, Evans TJ, Rahman MM, Keka IS, Tsuda M, Sasanuma H, Takeda S.

Proc Natl Acad Sci U S A. 2018 Dec 11;115(50):12793-12798. doi: 10.1073/pnas.1716349115. Epub 2018 Nov 28.

11.

BRCA1 ensures genome integrity by eliminating estrogen-induced pathological topoisomerase II-DNA complexes.

Sasanuma H, Tsuda M, Morimoto S, Saha LK, Rahman MM, Kiyooka Y, Fujiike H, Cherniack AD, Itou J, Callen Moreu E, Toi M, Nakada S, Tanaka H, Tsutsui K, Yamada S, Nussenzweig A, Takeda S.

Proc Natl Acad Sci U S A. 2018 Nov 6;115(45):E10642-E10651. doi: 10.1073/pnas.1803177115. Epub 2018 Oct 23.

12.

Genistein-induced DNA damage is repaired by nonhomologous end joining and homologous recombination in TK6 cells.

Hu X, Wu X, Liu H, Cheng Z, Zhao Z, Xiang C, Feng X, Takeda S, Qing Y.

J Cell Physiol. 2019 Mar;234(3):2683-2692. doi: 10.1002/jcp.27082. Epub 2018 Aug 2.

PMID:
30070703
13.

SPARTAN promotes genetic diversification of the immunoglobulin-variable gene locus in avian DT40 cells.

Nakazato A, Kajita K, Ooka M, Akagawa R, Abe T, Takeda S, Branzei D, Hirota K.

DNA Repair (Amst). 2018 Aug;68:50-57. doi: 10.1016/j.dnarep.2018.06.003. Epub 2018 Jun 18.

PMID:
29935364
14.

Differential micronucleus frequency in isogenic human cells deficient in DNA repair pathways is a valuable indicator for evaluating genotoxic agents and their genotoxic mechanisms.

Saha LK, Kim S, Kang H, Akter S, Choi K, Sakuma T, Yamamoto T, Sasanuma H, Hirota K, Nakamura J, Honma M, Takeda S, Dertinger S.

Environ Mol Mutagen. 2018 Jul;59(6):529-538. doi: 10.1002/em.22201. Epub 2018 May 15.

PMID:
29761828
15.

Correction: The BRCT Domain of PARP-1 Is Required for Immunoglobulin Gene Conversion.

Paddock MN, Buelow BD, Takeda S, Scharenberg AM.

PLoS Biol. 2018 Mar 1;16(3):e1002621. doi: 10.1371/journal.pbio.1002621. eCollection 2018 Mar.

16.

Chromatin remodeler ALC1 prevents replication-fork collapse by slowing fork progression.

Ooka M, Abe T, Cho K, Koike K, Takeda S, Hirota K.

PLoS One. 2018 Feb 6;13(2):e0192421. doi: 10.1371/journal.pone.0192421. eCollection 2018.

17.

Chemogenomic Active Learning's Domain of Applicability on Small, Sparse qHTS Matrices: A Study Using Cytochrome P450 and Nuclear Hormone Receptor Families.

Rakers C, Najnin RA, Polash AH, Takeda S, Brown JB.

ChemMedChem. 2018 Mar 20;13(6):511-521. doi: 10.1002/cmdc.201700677. Epub 2018 Feb 5.

PMID:
29211346
18.

Disruption of Hif-1α enhances cytotoxic effects of metformin in murine squamous cell carcinoma.

Sanada Y, Sasanuma H, Takeda S, Tano K, Masunaga SI.

Int J Radiat Biol. 2018 Jan;94(1):88-96. doi: 10.1080/09553002.2018.1409443. Epub 2017 Dec 12.

PMID:
29185833
19.

ALC1/CHD1L, a chromatin-remodeling enzyme, is required for efficient base excision repair.

Tsuda M, Cho K, Ooka M, Shimizu N, Watanabe R, Yasui A, Nakazawa Y, Ogi T, Harada H, Agama K, Nakamura J, Asada R, Fujiike H, Sakuma T, Yamamoto T, Murai J, Hiraoka M, Koike K, Pommier Y, Takeda S, Hirota K.

PLoS One. 2017 Nov 17;12(11):e0188320. doi: 10.1371/journal.pone.0188320. eCollection 2017.

20.

Complementation of aprataxin deficiency by base excision repair enzymes in mitochondrial extracts.

Çaglayan M, Prasad R, Krasich R, Longley MJ, Kadoda K, Tsuda M, Sasanuma H, Takeda S, Tano K, Copeland WC, Wilson SH.

Nucleic Acids Res. 2017 Sep 29;45(17):10079-10088. doi: 10.1093/nar/gkx654.

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