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Items: 1 to 20 of 52


Elucidation of Molecular Mechanism of a Selective PPARα Modulator, Pemafibrate, through Combinational Approaches of X-ray Crystallography, Thermodynamic Analysis, and First-Principle Calculations.

Kawasaki M, Kambe A, Yamamoto Y, Arulmozhiraja S, Ito S, Nakagawa Y, Tokiwa H, Nakano S, Shimano H.

Int J Mol Sci. 2020 Jan 6;21(1). pii: E361. doi: 10.3390/ijms21010361.


Endoscopic ultrasound-guided fine-needle aspiration of sigmoid colon cancer undiagnosed with endoscopic biopsy.

Nakano S, Minaga K, Yamashita Y.

Arab J Gastroenterol. 2019 Dec;20(4):209-210. doi: 10.1016/j.ajg.2019.11.001. Epub 2019 Nov 20. No abstract available.


The Japanese Breast Cancer Society Clinical Practice Guidelines for Breast Cancer Screening and Diagnosis, 2018 Edition.

Uematsu T, Nakashima K, Kikuchi M, Kubota K, Suzuki A, Nakano S, Hirokaga K, Yamaguchi K, Saji S, Iwata H.

Breast Cancer. 2020 Jan;27(1):17-24. doi: 10.1007/s12282-019-01025-7. Epub 2019 Nov 16.


Kinetics-Based Structural Requirements of Human Immunoglobulin G Binding Peptides.

Muguruma K, Fujita K, Fukuda A, Kishimoto S, Sakamoto S, Arima R, Ito M, Kawasaki M, Nakano S, Ito S, Shimizu K, Taguchi A, Takayama K, Taniguchi A, Ito Y, Hayashi Y.

ACS Omega. 2019 Aug 28;4(11):14390-14397. doi: 10.1021/acsomega.9b01104. eCollection 2019 Sep 10.


Competitive Binding Assay with an Umbelliferone-Based Fluorescent Rexinoid for Retinoid X Receptor Ligand Screening.

Yamada S, Kawasaki M, Fujihara M, Watanabe M, Takamura Y, Takioku M, Nishioka H, Takeuchi Y, Makishima M, Motoyama T, Ito S, Tokiwa H, Nakano S, Kakuta H.

J Med Chem. 2019 Oct 10;62(19):8809-8818. doi: 10.1021/acs.jmedchem.9b00995. Epub 2019 Sep 18.


Current conditions and issues of physicians and working conditions at institutions accredited by the Japanese Breast Cancer Society.

Kawase K, Yamashita H, Iwase H, Akashi-Tanaka S, Iijima K, Ishida T, Takeishi Y, Tanaka F, Doihara H, Nakano S, Yamauchi H, Masuda S.

Breast Cancer. 2019 Aug 22. doi: 10.1007/s12282-019-01005-x. [Epub ahead of print]


Following the Evolutionary Track of a Highly Specific l-Arginine Oxidase by Reconstruction and Biochemical Analysis of Ancestral and Native Enzymes.

Nakano S, Niwa M, Asano Y, Ito S.

Appl Environ Microbiol. 2019 May 30;85(12). pii: e00459-19. doi: 10.1128/AEM.00459-19. Print 2019 Jun 15.


Dual conformation of the ligand induces the partial agonistic activity of retinoid X receptor α (RXRα).

Miyashita Y, Numoto N, Arulmozhiraja S, Nakano S, Matsuo N, Shimizu K, Shibahara O, Fujihara M, Kakuta H, Ito S, Ikura T, Ito N, Tokiwa H.

FEBS Lett. 2019 Jan;593(2):242-250. doi: 10.1002/1873-3468.13301. Epub 2018 Dec 21.


Development of an Analysis Toolkit, AnalysisFMO, to Visualize Interaction Energies Generated by Fragment Molecular Orbital Calculations.

Tokiwa T, Nakano S, Yamamoto Y, Ishikawa T, Ito S, Sladek V, Fukuzawa K, Mochizuki Y, Tokiwa H, Misaizu F, Shigeta Y.

J Chem Inf Model. 2019 Jan 28;59(1):25-30. doi: 10.1021/acs.jcim.8b00649. Epub 2018 Dec 20.


Improvement of ST0452 N-Acetylglucosamine-1-Phosphate Uridyltransferase Activity by the Cooperative Effect of Two Single Mutations Identified through Structure-Based Protein Engineering.

Honda Y, Nakano S, Ito S, Dadashipour M, Zhang Z, Kawarabayasi Y.

Appl Environ Microbiol. 2018 Nov 30;84(24). pii: e02213-18. doi: 10.1128/AEM.02213-18. Print 2018 Dec 15.


Computational Molecular Docking and X-ray Crystallographic Studies of Catechins in New Drug Design Strategies.

Nakano S, Megro SI, Hase T, Suzuki T, Isemura M, Nakamura Y, Ito S.

Molecules. 2018 Aug 13;23(8). pii: E2020. doi: 10.3390/molecules23082020. Review.


In Vitro and In Silico Studies of the Molecular Interactions of Epigallocatechin-3-O-gallate (EGCG) with Proteins That Explain the Health Benefits of Green Tea.

Saeki K, Hayakawa S, Nakano S, Ito S, Oishi Y, Suzuki Y, Isemura M.

Molecules. 2018 May 28;23(6). pii: E1295. doi: 10.3390/molecules23061295. Review.


Benchmark Analysis of Native and Artificial NAD+-Dependent Enzymes Generated by a Sequence-Based Design Method with or without Phylogenetic Data.

Nakano S, Motoyama T, Miyashita Y, Ishizuka Y, Matsuo N, Tokiwa H, Shinoda S, Asano Y, Ito S.

Biochemistry. 2018 Jul 3;57(26):3722-3732. doi: 10.1021/acs.biochem.8b00339. Epub 2018 Jun 4.


Binding of Catechins to Staphylococcal Enterotoxin A.

Shimamura Y, Utsumi M, Hirai C, Nakano S, Ito S, Tsuji A, Ishii T, Hosoya T, Kan T, Ohashi N, Masuda S.

Molecules. 2018 May 9;23(5). pii: E1125. doi: 10.3390/molecules23051125.


Pre-Operative Planning Using Real-Time Virtual Sonography, an MRI/Ultrasound Image Fusion Technique, for Breast-Conserving Surgery in Patients with Non-Mass Enhancement on Breast MRI: A Preliminary Study.

Ando T, Ito Y, Ido M, Osawa M, Kousaka J, Mouri Y, Fujii K, Nakano S, Kimura J, Ishiguchi T, Watanebe R, Imai T, Fukutomi T.

Ultrasound Med Biol. 2018 Jul;44(7):1364-1370. doi: 10.1016/j.ultrasmedbio.2018.03.001. Epub 2018 Apr 10.


Alterations in three biomarkers (estrogen receptor, progesterone receptor and human epidermal growth factor 2) and the Ki67 index between primary and metastatic breast cancer lesions.

Fujii K, Watanabe R, Ando T, Kousaka J, Mouri Y, Yoshida M, Imai T, Nakano S, Fukutomi T.

Biomed Rep. 2017 Dec;7(6):535-542. doi: 10.3892/br.2017.1003. Epub 2017 Oct 19.


Product Release Mechanism Associated with Structural Changes in Monomeric l-Threonine 3-Dehydrogenase.

Motoyama T, Nakano S, Yamamoto Y, Tokiwa H, Asano Y, Ito S.

Biochemistry. 2017 Oct 31;56(43):5758-5770. doi: 10.1021/acs.biochem.7b00832. Epub 2017 Oct 19.


Rational identification of aggregation hotspots based on secondary structure and amino acid hydrophobicity.

Matsui D, Nakano S, Dadashipour M, Asano Y.

Sci Rep. 2017 Aug 25;7(1):9558. doi: 10.1038/s41598-017-09749-2.


Azo-polymer film twisted to form a helical surface relief by illumination with a circularly polarized Gaussian beam.

Masuda K, Nakano S, Barada D, Kumakura M, Miyamoto K, Omatsu T.

Opt Express. 2017 May 29;25(11):12499-12507. doi: 10.1364/OE.25.012499.


Second-look US Using Real-time Virtual Sonography, a Coordinated Breast US and MRI System with Electromagnetic Tracking Technology: A Pilot Study.

Watanabe R, Ando T, Osawa M, Ido M, Kousaka J, Mouri Y, Fujii K, Nakano S, Kimura J, Ishiguchi T, Yoshida M, Imai T, Fukutomi T.

Ultrasound Med Biol. 2017 Oct;43(10):2362-2371. doi: 10.1016/j.ultrasmedbio.2017.04.024. Epub 2017 Jun 27.


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