Format

Send to

Choose Destination
Brain Dev. 2018 Sep;40(8):685-692. doi: 10.1016/j.braindev.2018.04.006. Epub 2018 May 3.

Treatment of infantile spasms by pediatric neurologists in Japan.

Author information

1
Division of Neurology, Saitama Children's Medical Center, Saitama, Japan; Department for Child Health and Human Development, Saitama Children's Medical Center, Saitama, Japan. Electronic address: hamano.shinichiro@scmc.pref.saitama.jp.
2
Department of Education, Faculty of Education, Poole Gakuin University and College, Osaka, Japan.
3
Division of Neurology, Saitama Children's Medical Center, Saitama, Japan.
4
Department for Child Health and Human Development, Saitama Children's Medical Center, Saitama, Japan.

Abstract

OBJECTIVE:

To clarify changes in clinical practice for infantile spasms, including West syndrome, in Japan over the past two decades.

METHODS:

We investigated common treatment strategies for infantile spasms among 157 pediatric neurologists from a designated training facility for pediatric neurology and/or a designated training facility for epilepsy in Japan. A questionnaire was used to investigate use of adrenocorticotropic hormone (ACTH) therapy including daily dose, treatment duration, and tapering off period, and preferred first to fifth-line treatment choices.

RESULTS:

Among 119 responses (75.8%), 107 enabled analysis of ACTH therapy and 112 were used to determine preferred order of first to fifth-line treatments. Over 80% respondents reported an initial ACTH dose of ≤0.0125 mg/kg/day, with a treatment duration of 14 days and various tapering periods. Following an unfavorable response of seizures to ACTH, 80% respondents increased the dose and/or extended treatment duration. The same ACTH therapy regimen was performed for symptomatic and cryptogenic patients at 95 facilities (88.8%). Preferred orders of therapeutic agents were the same for both symptomatic and cryptogenic patients at 64 facilities (57.1%). Over half the respondents selected vitamin B6 or valproate as the first and second-line treatments instead of ACTH therapy, while ACTH therapy was the most frequently selected third-line treatment.

CONCLUSIONS:

Current ACTH therapy regimens have lower doses and shorter durations than previously reported. However, treatment strategies for infantile spasms have not changed much in two decades. ACTH therapy should be the first/second-line treatment rather than third-line or later, especially for cryptogenic infantile spasms.

KEYWORDS:

Adrenocorticotropic hormone; Epilepsy; Epileptic spasms; Valproate; Vigabatrin; Vitamin B6; West syndrome

PMID:
29731400
DOI:
10.1016/j.braindev.2018.04.006
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center