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Items: 1 to 20 of 109


Rapamycin inhibits B-cell activating factor (BAFF)-stimulated cell proliferation and survival by suppressing Ca2+-CaMKII-dependent PTEN/Akt-Erk1/2 signaling pathway in normal and neoplastic B-lymphoid cells.

Zeng Q, Zhou Z, Qin S, Yao Y, Qin J, Zhang H, Zhang R, Xu C, Zhang S, Huang S, Chen L.

Cell Calcium. 2020 Feb 7;87:102171. doi: 10.1016/j.ceca.2020.102171. [Epub ahead of print]


Cadmium induces mitochondrial ROS inactivation of XIAP pathway leading to apoptosis in neuronal cells.

Zhao R, Yu Q, Hou L, Dong X, Zhang H, Chen X, Zhou Z, Ma J, Huang S, Chen L.

Int J Biochem Cell Biol. 2020 Feb 5;121:105715. doi: 10.1016/j.biocel.2020.105715. [Epub ahead of print]


ReishiMax inhibits mTORC1/2 by activating AMPK and inhibiting IGFR/PI3K/Rheb in tumor cells.

Sohretoglu D, Zhang C, Luo J, Huang S.

Signal Transduct Target Ther. 2019 Jun 28;4:21. doi: 10.1038/s41392-019-0056-7. eCollection 2019.


Artesunate enhances the immune response of rabies vaccine as an adjuvant.

Luo J, Zhang Y, He H, Liu Q, Huang S, Guo X.

Vaccine. 2019 Dec 3;37(51):7478-7481. doi: 10.1016/j.vaccine.2019.09.077. Epub 2019 Sep 30.


Fisetin, a 3,7,3',4'-Tetrahydroxyflavone Inhibits the PI3K/Akt/mTOR and MAPK Pathways and Ameliorates Psoriasis Pathology in 2D and 3D Organotypic Human Inflammatory Skin Models.

Chamcheu JC, Esnault S, Adhami VM, Noll AL, Banang-Mbeumi S, Roy T, Singh SS, Huang S, Kousoulas KG, Mukhtar H.

Cells. 2019 Sep 15;8(9). pii: E1089. doi: 10.3390/cells8091089.


Role and Therapeutic Targeting of the PI3K/Akt/mTOR Signaling Pathway in Skin Cancer: A Review of Current Status and Future Trends on Natural and Synthetic Agents Therapy.

Chamcheu JC, Roy T, Uddin MB, Banang-Mbeumi S, Chamcheu RN, Walker AL, Liu YY, Huang S.

Cells. 2019 Jul 31;8(8). pii: E803. doi: 10.3390/cells8080803. Review.


Beta-elemene inhibits breast cancer metastasis through blocking pyruvate kinase M2 dimerization and nuclear translocation.

Pan Y, Wang W, Huang S, Ni W, Wei Z, Cao Y, Yu S, Jia Q, Wu Y, Chai C, Zheng Q, Zhang L, Wang A, Sun Z, Huang S, Wang S, Chen W, Lu Y.

J Cell Mol Med. 2019 Oct;23(10):6846-6858. doi: 10.1111/jcmm.14568. Epub 2019 Jul 25.


Maduramicin inactivation of Akt impairs autophagic flux leading to accumulated autophagosomes-dependent apoptosis in skeletal myoblast cells.

Dong X, Zhao R, Li Y, Yu Q, Chen X, Hu X, Ma J, Chen X, Huang S, Chen L.

Int J Biochem Cell Biol. 2019 Sep;114:105573. doi: 10.1016/j.biocel.2019.105573. Epub 2019 Jul 17.


Maduramicin induces apoptosis through ROS-PP5-JNK pathway in skeletal myoblast cells and muscle tissue.

Chen X, Zhang Y, Jiang S, Huang S.

Toxicology. 2019 Aug 1;424:152239. doi: 10.1016/j.tox.2019.152239. Epub 2019 Jun 20.


Novel lncRNA-IUR suppresses Bcr-Abl-induced tumorigenesis through regulation of STAT5-CD71 pathway.

Wang X, Yang J, Guo G, Feng R, Chen K, Liao Y, Zhang L, Sun L, Huang S, Chen JL.

Mol Cancer. 2019 Apr 8;18(1):84. doi: 10.1186/s12943-019-1013-3.


Correction to: Cryptotanshinone activates AMPK-TSC2 axis leading to inhibition of mTORC1 signaling in cancer cells.

Chen W, Pan Y, Wang S, Liu Y, Chen G, Zhou L, Zhang C, Ni W, Wang A, Lu Y, Huang S.

BMC Cancer. 2019 Mar 21;19(1):257. doi: 10.1186/s12885-019-5458-y.


The bromodomain protein BRD4 positively regulates necroptosis via modulating MLKL expression.

Xiong Y, Li L, Zhang L, Cui Y, Wu C, Li H, Chen K, Yang Q, Xiang R, Hu Y, Huang S, Wei Y, Yang S.

Cell Death Differ. 2019 Oct;26(10):1929-1941. doi: 10.1038/s41418-018-0262-9. Epub 2019 Jan 15.


Cadmium results in accumulation of autophagosomes-dependent apoptosis through activating Akt-impaired autophagic flux in neuronal cells.

Zhang H, Dong X, Zhao R, Zhang R, Xu C, Wang X, Liu C, Hu X, Huang S, Chen L.

Cell Signal. 2019 Mar;55:26-39. doi: 10.1016/j.cellsig.2018.12.008. Epub 2018 Dec 19.


Maduramicin induces cardiac muscle cell death by the ROS-dependent PTEN/Akt-Erk1/2 signaling pathway.

Chen X, Li Y, Feng M, Hu X, Zhang H, Zhang R, Dong X, Liu C, Zhang Z, Jiang S, Huang S, Chen L.

J Cell Physiol. 2019 Jul;234(7):10964-10976. doi: 10.1002/jcp.27830. Epub 2018 Dec 3.


BAFF inhibits autophagy promoting cell proliferation and survival by activating Ca2+-CaMKII-dependent Akt/mTOR signaling pathway in normal and neoplastic B-lymphoid cells.

Dong X, Qin J, Ma J, Zeng Q, Zhang H, Zhang R, Liu C, Xu C, Zhang S, Huang S, Chen L.

Cell Signal. 2019 Jan;53:68-79. doi: 10.1016/j.cellsig.2018.09.012. Epub 2018 Sep 20.


Interaction of Abl Tyrosine Kinases with SOCS3 Impairs Its Suppressor Function in Tumorigenesis.

Feng R, Wang X, Li J, Chen K, Guo G, Liao Y, Sun L, Huang S, Chen JL.

Neoplasia. 2018 Nov;20(11):1095-1105. doi: 10.1016/j.neo.2018.09.002. Epub 2018 Sep 18.


Resveratrol inhibits Erk1/2-mediated adhesion of cancer cells via activating PP2A-PTEN signaling network.

Chen X, Hu X, Li Y, Zhu C, Dong X, Zhang R, Ma J, Huang S, Chen L.

J Cell Physiol. 2019 Mar;234(3):2822-2836. doi: 10.1002/jcp.27100. Epub 2018 Aug 1.


Ciclopirox activates ATR-Chk1 signaling pathway leading to Cdc25A protein degradation.

Shen T, Zhou H, Shang C, Luo Y, Wu Y, Huang S.

Genes Cancer. 2018 Jan;9(1-2):39-52. doi: 10.18632/genesandcancer.166.


Host Immune Response to Influenza A Virus Infection.

Chen X, Liu S, Goraya MU, Maarouf M, Huang S, Chen JL.

Front Immunol. 2018 Mar 5;9:320. doi: 10.3389/fimmu.2018.00320. eCollection 2018. Review.

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