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Items: 1 to 20 of 34


Poly-ADP ribosylation in DNA damage response and cancer therapy.

Hou WH, Chen SH, Yu X.

Mutat Res. 2019 Apr - Jun;780:82-91. doi: 10.1016/j.mrrev.2017.09.004. Epub 2017 Sep 20. Review.


Targeting dePARylation selectively suppresses DNA repair-defective and PARP inhibitor-resistant malignancies.

Chen SH, Yu X.

Sci Adv. 2019 Apr 10;5(4):eaav4340. doi: 10.1126/sciadv.aav4340. eCollection 2019 Apr.


NADP+ is an endogenous PARP inhibitor in DNA damage response and tumor suppression.

Bian C, Zhang C, Luo T, Vyas A, Chen SH, Liu C, Kassab MA, Yang Y, Kong M, Yu X.

Nat Commun. 2019 Feb 11;10(1):693. doi: 10.1038/s41467-019-08530-5.


Human DNA ligase IV is able to use NAD+ as an alternative adenylation donor for DNA ends ligation.

Chen SH, Yu X.

Nucleic Acids Res. 2019 Feb 20;47(3):1321-1334. doi: 10.1093/nar/gky1202.


Sintering Pmperature-Dependence on Radiopacity of Bi(2-x) ZrxO(3+x/2) Powders Prepared by Sol-Gel Process.

Chen MS, Chen SH, Lai FC, Chen CY, Hsieh MY, Chang WJ, Yang JC, Lin CK.

Materials (Basel). 2018 Sep 11;11(9). pii: E1685. doi: 10.3390/ma11091685.


Super-resolution imaging identifies PARP1 and the Ku complex acting as DNA double-strand break sensors.

Yang G, Liu C, Chen SH, Kassab MA, Hoff JD, Walter NG, Yu X.

Nucleic Acids Res. 2018 Apr 20;46(7):3446-3457. doi: 10.1093/nar/gky088.


Fabrication of device with poly(N-isopropylacrylamide)-b-ssDNA copolymer brush for resistivity study.

Liu YZ, Chen MS, Cheng CC, Chen SH, Chen JK.

J Nanobiotechnology. 2017 Oct 5;15(1):68. doi: 10.1186/s12951-017-0303-4.


Effect of Hydroxyapatite on the Mechanical Properties and Corrosion Behavior of Mg-Zn-Y Alloy.

Chiu C, Lu CT, Chen SH, Ou KL.

Materials (Basel). 2017 Jul 26;10(8). pii: E855. doi: 10.3390/ma10080855.


In vitro study of electrodeposited fluoridated hydroxyapatite coating on G-II titanium with a nanostructured TiO2 interlayer.

Lin JS, Tsai TB, Say WC, Chiu C, Chen SH.

Biomed Mater. 2017 Apr 4;12(2):025018. doi: 10.1088/1748-605X/aa6264.


The fabrication and thermal properties of bismuth-aluminum oxide nanothermometers.

Wang CY, Chen SH, Tsai PH, Chiou CH, Hsieh SJ.

Nanotechnology. 2017 Jan 27;28(4):045705. doi: 10.1088/1361-6528/28/4/045705. Epub 2016 Dec 16.


New Flexible Silicone-Based EEG Dry Sensor Material Compositions Exhibiting Improvements in Lifespan, Conductivity, and Reliability.

Yu YH, Chen SH, Chang CL, Lin CT, Hairston WD, Mrozek RA.

Sensors (Basel). 2016 Oct 31;16(11). pii: E1826.


Oncogenic BRAF Deletions That Function as Homodimers and Are Sensitive to Inhibition by RAF Dimer Inhibitor LY3009120.

Chen SH, Zhang Y, Van Horn RD, Yin T, Buchanan S, Yadav V, Mochalkin I, Wong SS, Yue YG, Huber L, Conti I, Henry JR, Starling JJ, Plowman GD, Peng SB.

Cancer Discov. 2016 Mar;6(3):300-15. doi: 10.1158/2159-8290.CD-15-0896. Epub 2016 Jan 5.


The PIN domain of EXO1 recognizes poly(ADP-ribose) in DNA damage response.

Zhang F, Shi J, Chen SH, Bian C, Yu X.

Nucleic Acids Res. 2015 Dec 15;43(22):10782-94. doi: 10.1093/nar/gkv939. Epub 2015 Sep 22.


Inhibition of RAF Isoforms and Active Dimers by LY3009120 Leads to Anti-tumor Activities in RAS or BRAF Mutant Cancers.

Peng SB, Henry JR, Kaufman MD, Lu WP, Smith BD, Vogeti S, Rutkoski TJ, Wise S, Chun L, Zhang Y, Van Horn RD, Yin T, Zhang X, Yadav V, Chen SH, Gong X, Ma X, Webster Y, Buchanan S, Mochalkin I, Huber L, Kays L, Donoho GP, Walgren J, McCann D, Patel P, Conti I, Plowman GD, Starling JJ, Flynn DL.

Cancer Cell. 2015 Sep 14;28(3):384-98. doi: 10.1016/j.ccell.2015.08.002. Epub 2015 Sep 3.


Co-targeting BRAF and cyclin dependent kinases 4/6 for BRAF mutant cancers.

Yadav V, Chen SH, Yue YG, Buchanan S, Beckmann RP, Peng SB.

Pharmacol Ther. 2015 May;149:139-49. doi: 10.1016/j.pharmthera.2014.12.003. Epub 2014 Dec 27. Review.


Identification, synthesis, and evaluation of new neuraminidase inhibitors.

Kumar V, Chang CK, Tan KP, Jung YS, Chen SH, Cheng YS, Liang PH.

Org Lett. 2014 Oct 3;16(19):5060-3. doi: 10.1021/ol502410x. Epub 2014 Sep 17.


Water permeation drives tumor cell migration in confined microenvironments.

Stroka KM, Jiang H, Chen SH, Tong Z, Wirtz D, Sun SX, Konstantopoulos K.

Cell. 2014 Apr 24;157(3):611-23. doi: 10.1016/j.cell.2014.02.052. Epub 2014 Apr 10.


Conjugation of benzylvanillin and benzimidazole structure improves DNA binding with enhanced antileukemic properties.

Al-Mudaris ZA, Majid AS, Ji D, Al-Mudarris BA, Chen SH, Liang PH, Osman H, Jamal Din SK, Abdul Majid AM.

PLoS One. 2013 Nov 15;8(11):e80983. doi: 10.1371/journal.pone.0080983. eCollection 2013.


Impact of flavonoids on matrix metalloproteinase secretion and invadopodia formation in highly invasive A431-III cancer cells.

Lin YC, Tsai PH, Lin CY, Cheng CH, Lin TH, Lee KP, Huang KY, Chen SH, Hwang JJ, Kandaswami CC, Lee MT.

PLoS One. 2013 Aug 21;8(8):e71903. doi: 10.1371/journal.pone.0071903. eCollection 2013.


Distinct signaling mechanisms regulate migration in unconfined versus confined spaces.

Hung WC, Chen SH, Paul CD, Stroka KM, Lo YC, Yang JT, Konstantopoulos K.

J Cell Biol. 2013 Sep 2;202(5):807-24. doi: 10.1083/jcb.201302132. Epub 2013 Aug 26.

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