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Items: 1 to 20 of 361


A Novel CXCR4 Targeting Protein SDF-1/54 as an HIV-1 Entry Inhibitor.

Tan S, Li W, Li Z, Li Y, Luo J, Yu L, Yang J, Qiu M, Cheng H, Xu W, Jiang S, Lu L, Liu S, Ma W.

Viruses. 2019 Sep 18;11(9). pii: E874. doi: 10.3390/v11090874.


Design and Biological Evaluation of m-Xylene Thioether-stapled Short Helical Peptides Targeting the HIV-1 gp41 Hexameric Coiled-Coil Fusion Complex.

Meng G, Pu J, Li Y, Han A, Tian Y, Xu W, Zhang T, Li X, Lu L, Wang C, Jiang S, Liu K.

J Med Chem. 2019 Sep 12. doi: 10.1021/acs.jmedchem.9b00882. [Epub ahead of print]


Long-Acting HIV-1 Fusion Inhibitory Peptides and their Mechanisms of Action.

Wang C, Cheng S, Zhang Y, Ding Y, Chong H, Xing H, Jiang S, Li X, Ma L.

Viruses. 2019 Sep 2;11(9). pii: E811. doi: 10.3390/v11090811.


Crystal Structure of Refolding Fusion Core of Lassa Virus GP2 and Design of Lassa Virus Fusion Inhibitors.

Zhang X, Wang C, Chen B, Wang Q, Xu W, Ye S, Jiang S, Zhu Y, Zhang R.

Front Microbiol. 2019 Aug 13;10:1829. doi: 10.3389/fmicb.2019.01829. eCollection 2019.


N-Substituted Pyrrole Derivative 12m Inhibits HIV-1 Entry by Targeting Gp41 of HIV-1 Envelope Glycoprotein.

Qiu J, Liang T, Wu J, Yu F, He X, Tian Y, Xie L, Jiang S, Liu S, Li L.

Front Pharmacol. 2019 Aug 2;10:859. doi: 10.3389/fphar.2019.00859. eCollection 2019.


In Silico Identification of Novel Aromatic Compounds as Potential HIV-1 Entry Inhibitors Mimicking Cellular Receptor CD4.

Andrianov AM, Nikolaev GI, Kornoushenko YV, Xu W, Jiang S, Tuzikov AV.

Viruses. 2019 Aug 13;11(8). pii: E746. doi: 10.3390/v11080746.


Rapid elimination of broadly neutralizing antibodies correlates with treatment failure in the acute phase of SHIV infection.

Wu Y, Xue J, Wang C, Li W, Wang L, Chen W, Prabakaran P, Kong D, Jin Y, Hu D, Wang Y, Lei C, Yu D, Tu C, Bardhi A, Sidorov I, Ma L, Goldstein H, Qin C, Lu L, Jiang S, Dimitrov DS, Ying T.

J Virol. 2019 Aug 2. pii: JVI.01077-19. doi: 10.1128/JVI.01077-19. [Epub ahead of print]


Development of Protein- and Peptide-Based HIV Entry Inhibitors Targeting gp120 or gp41.

Pu J, Wang Q, Xu W, Lu L, Jiang S.

Viruses. 2019 Aug 1;11(8). pii: E705. doi: 10.3390/v11080705. Review.


A pan-coronavirus fusion inhibitor targeting the HR1 domain of human coronavirus spike.

Xia S, Yan L, Xu W, Agrawal AS, Algaissi A, Tseng CK, Wang Q, Du L, Tan W, Wilson IA, Jiang S, Yang B, Lu L.

Sci Adv. 2019 Apr 10;5(4):eaav4580. doi: 10.1126/sciadv.aav4580. eCollection 2019 Apr.


Revisiting the mechanism of enfuvirtide and designing an analog with improved fusion inhibitory activity by targeting triple sites in gp41.

Xu W, Pu J, Su S, Hua C, Su X, Wang Q, Jiang S, Lu L.

AIDS. 2019 Aug 1;33(10):1545-1555. doi: 10.1097/QAD.0000000000002208.


A Peptide-Based HIV-1 Fusion Inhibitor with Two Tail-Anchors and Palmitic Acid Exhibits Substantially Improved In Vitro and Ex Vivo Anti-HIV-1 Activity and Prolonged In Vivo Half-Life.

Su S, Rasquinha G, Du L, Wang Q, Xu W, Li W, Lu L, Jiang S.

Molecules. 2019 Mar 21;24(6). pii: E1134. doi: 10.3390/molecules24061134.


Transfusion-Transmitted Zika Virus Infection in Pregnant Mice Leads to Broad Tissue Tropism With Severe Placental Damage and Fetal Demise.

Tai W, Voronin D, Chen J, Bao W, Kessler DA, Shaz B, Jiang S, Yazdanbakhsh K, Du L.

Front Microbiol. 2019 Jan 23;10:29. doi: 10.3389/fmicb.2019.00029. eCollection 2019.


Sin1/mTORC2 regulate B cell growth and metabolism by activating mTORC1 and Myc.

Li M, Lazorchak AS, Ouyang X, Zhang H, Liu H, Arojo OA, Yan L, Jin J, Han Y, Qu G, Fu Y, Xu X, Liu X, Zhang W, Yang Z, Ruan C, Wang Q, Liu D, Huang C, Lu L, Jiang S, Li F, Su B.

Cell Mol Immunol. 2019 Sep;16(9):757-769. doi: 10.1038/s41423-018-0185-x. Epub 2019 Jan 31.


Metformin combined with nelfinavir induces SIRT3/mROS-dependent autophagy in human cervical cancer cells and xenograft in nude mice.

Xia C, He Z, Liang S, Chen R, Xu W, Yang J, Xiao G, Jiang S.

Eur J Pharmacol. 2019 Apr 5;848:62-69. doi: 10.1016/j.ejphar.2019.01.045. Epub 2019 Jan 26.


Advances in MERS-CoV Vaccines and Therapeutics Based on the Receptor-Binding Domain.

Zhou Y, Yang Y, Huang J, Jiang S, Du L.

Viruses. 2019 Jan 14;11(1). pii: E60. doi: 10.3390/v11010060. Review.


Potent MERS-CoV Fusion Inhibitory Peptides Identified from HR2 Domain in Spike Protein of Bat Coronavirus HKU4.

Xia S, Lan Q, Pu J, Wang C, Liu Z, Xu W, Wang Q, Liu H, Jiang S, Lu L.

Viruses. 2019 Jan 14;11(1). pii: E56. doi: 10.3390/v11010056.


Development of Small-Molecule MERS-CoV Inhibitors.

Liang R, Wang L, Zhang N, Deng X, Su M, Su Y, Hu L, He C, Ying T, Jiang S, Yu F.

Viruses. 2018 Dec 17;10(12). pii: E721. doi: 10.3390/v10120721. Review.


Characterization by high-resolution crystal structure analysis of a triple-helix region of human collagen type III with potent cell adhesion activity.

Hua C, Zhu Y, Xu W, Ye S, Zhang R, Lu L, Jiang S.

Biochem Biophys Res Commun. 2019 Jan 22;508(4):1018-1023. doi: 10.1016/j.bbrc.2018.12.018. Epub 2018 Dec 11.


The Antihistamine Drugs Carbinoxamine Maleate and Chlorpheniramine Maleate Exhibit Potent Antiviral Activity Against a Broad Spectrum of Influenza Viruses.

Xu W, Xia S, Pu J, Wang Q, Li P, Lu L, Jiang S.

Front Microbiol. 2018 Nov 6;9:2643. doi: 10.3389/fmicb.2018.02643. eCollection 2018.

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