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Items: 1 to 20 of 36

1.

Cytotoxicity Of Chalcone Of Eugenia aquea Burm F. Leaves Against T47D Breast Cancer Cell Lines And Its Prediction As An Estrogen Receptor Antagonist Based On Pharmacophore-Molecular Dynamics Simulation.

Muchtaridi M, Yusuf M, Syahidah HN, Subarnas A, Zamri A, Bryant SD, Langer T.

Adv Appl Bioinform Chem. 2019 Nov 6;12:33-43. doi: 10.2147/AABC.S217205. eCollection 2019.

2.

Molecular Docking and 3D-Pharmacophore Modeling to Study the Interactions of Chalcone Derivatives with Estrogen Receptor Alpha.

Muchtaridi M, Syahidah HN, Subarnas A, Yusuf M, Bryant SD, Langer T.

Pharmaceuticals (Basel). 2017 Oct 16;10(4). pii: E81. doi: 10.3390/ph10040081.

3.

Shaping the future of safer innovative drugs in Europe.

Mestres J, Bryant SD, Zamora I, Gasteiger J.

Nat Biotechnol. 2011 Sep 8;29(9):789-90. doi: 10.1038/nbt.1973. No abstract available.

PMID:
21904315
4.

Synthesis of opioidmimetics, 3-[H-Dmt-NH(CH(2))(m)]-6-[H-Dmt-NH(CH(2))(n)]-2(1H)-pyrazinones, and studies on structure-activity relationships.

Shiotani K, Miyazaki A, Li T, Tsuda Y, Yokoi T, Ambo A, Sasaki Y, Bryant SD, Jinsmaa Y, Lazarus LH, Okada Y.

Med Chem. 2007 Nov;3(6):583-98.

PMID:
18045209
5.

A new opioid designed multiple ligand derived from the micro opioid agonist endomorphin-2 and the delta opioid antagonist pharmacophore Dmt-Tic.

Salvadori S, Trapella C, Fiorini S, Negri L, Lattanzi R, Bryant SD, Jinsmaa Y, Lazarus LH, Balboni G.

Bioorg Med Chem. 2007 Nov 15;15(22):6876-81. Epub 2007 Aug 29.

6.

Design and synthesis of opioidmimetics containing 2',6'-dimethyl-L-tyrosine and a pyrazinone-ring platform.

Shiotani K, Li T, Miyazaki A, Tsuda Y, Yokoi T, Ambo A, Sasaki Y, Bryant SD, Lazarus LH, Okada Y.

Bioorg Med Chem Lett. 2007 Nov 1;17(21):5768-71. Epub 2007 Aug 28.

7.

[N-allyl-Dmt1]-endomorphins are micro-opioid receptor antagonists lacking inverse agonist properties.

Marczak ED, Jinsmaa Y, Li T, Bryant SD, Tsuda Y, Okada Y, Lazarus LH.

J Pharmacol Exp Ther. 2007 Oct;323(1):374-80. Epub 2007 Jul 12.

PMID:
17626793
8.

Bifunctional [2',6'-dimethyl-L-tyrosine1]endomorphin-2 analogues substituted at position 3 with alkylated phenylalanine derivatives yield potent mixed mu-agonist/delta-antagonist and dual mu-agonist/delta-agonist opioid ligands.

Li T, Shiotani K, Miyazaki A, Tsuda Y, Ambo A, Sasaki Y, Jinsmaa Y, Marczak E, Bryant SD, Lazarus LH, Okada Y.

J Med Chem. 2007 Jun 14;50(12):2753-66. Epub 2007 May 12.

9.

Further studies on the effect of lysine at the C-terminus of the Dmt-Tic opioid pharmacophore.

Balboni G, Onnis V, Congiu C, Zotti M, Sasaki Y, Ambo A, Bryant SD, Jinsmaa Y, Lazarus LH, Lazzari I, Trapella C, Salvadori S.

Bioorg Med Chem. 2007 May 1;15(9):3143-51. Epub 2007 Feb 22.

10.

Transformation of mu-opioid receptor agonists into biologically potent mu-opioid receptor antagonists.

Li T, Jinsmaa Y, Nedachi M, Miyazaki A, Tsuda Y, Ambo A, Sasaki Y, Bryant SD, Marczak E, Li Q, Swartzwelder HS, Lazarus LH, Okada Y.

Bioorg Med Chem. 2007 Feb 1;15(3):1237-51. Epub 2006 Nov 14.

PMID:
17142049
11.

Synthesis of 3,6-bis[H-Tyr/H-Dmt-NH(CH2)m,n]-2(1H)pyrazinone derivatives: function of alkyl chain length on opioid activity.

Shiotani K, Li T, Miyazaki A, Tsuda Y, Bryant SD, Ambo A, Sasaki Y, Lazarus LH, Okada Y.

Bioorg Med Chem Lett. 2006 Nov 15;16(22):5793-6. Epub 2006 Sep 1.

12.

Effect of lysine at C-terminus of the Dmt-Tic opioid pharmacophore.

Balboni G, Onnis V, Congiu C, Zotti M, Sasaki Y, Ambo A, Bryant SD, Jinsmaa Y, Lazarus LH, Trapella C, Salvadori S.

J Med Chem. 2006 Sep 7;49(18):5610-7.

13.

New 2',6'-dimethyl-L-tyrosine (Dmt) opioid peptidomimetics based on the Aba-Gly scaffold. Development of unique mu-opioid receptor ligands.

Ballet S, Salvadori S, Trapella C, Bryant SD, Jinsmaa Y, Lazarus LH, Negri L, Giannini E, Lattanzi R, Tourwé D, Balboni G.

J Med Chem. 2006 Jun 29;49(13):3990-3.

14.

Potent in vivo antinociception and opioid receptor preference of the novel analogue [Dmt1]endomorphin-1.

Jinsmaa Y, Marczak E, Fujita Y, Shiotani K, Miyazaki A, Li T, Tsuda Y, Ambo A, Sasaki Y, Bryant SD, Okada Y, Lazarus LH.

Pharmacol Biochem Behav. 2006 Jun;84(2):252-8. Epub 2006 Jun 19.

PMID:
16782179
15.

6-N,N-dimethylamino-2,3-naphthalimide: a new environment-sensitive fluorescent probe in delta- and mu-selective opioid peptides.

Vázquez ME, Blanco JB, Salvadori S, Trapella C, Argazzi R, Bryant SD, Jinsmaa Y, Lazarus LH, Negri L, Giannini E, Lattanzi R, Colucci M, Balboni G.

J Med Chem. 2006 Jun 15;49(12):3653-8.

16.

Conversion of the potent delta-opioid agonist H-Dmt-Tic-NH-CH(2)-bid into delta-opioid antagonists by N(1)-benzimidazole alkylation(1).

Balboni G, Guerrini R, Salvadori S, Negri L, Giannini E, Bryant SD, Jinsmaa Y, Lazarus LH.

J Med Chem. 2005 Dec 29;48(26):8112-4.

17.

Potent Dmt-Tic pharmacophoric delta- and mu-opioid receptor antagonists.

Li T, Fujita Y, Shiotani K, Miyazaki A, Tsuda Y, Ambo A, Sasaki Y, Jinsmaa Y, Marczak E, Bryant SD, Salvadori S, Lazarus LH, Okada Y.

J Med Chem. 2005 Dec 15;48(25):8035-44.

PMID:
16335927
18.

New series of potent delta-opioid antagonists containing the H-Dmt-Tic-NH-hexyl-NH-R motif.

Li T, Shiotani K, Miyazaki A, Fujita Y, Tsuda Y, Ambo A, Sasaki Y, Jinsmaa Y, Marczak E, Bryant SD, Lazarus LH, Okada Y.

Bioorg Med Chem Lett. 2005 Dec 15;15(24):5517-20. Epub 2005 Sep 23.

PMID:
16183273
19.

Studies on the mechanism of 1,2-dihydropyrazin-2-one ring formation from dipeptidyl chloromethyl ketone and its chemical properties: immediate deamination during catalytic hydrogenation.

Miyazaki A, Fujisawa Y, Shiotani K, Fujita Y, Li T, Tsuda Y, Yokoi T, Bryant SD, Lazarus LH, Okada Y.

Chem Pharm Bull (Tokyo). 2005 Sep;53(9):1152-8.

20.

From the potent and selective mu opioid receptor agonist H-Dmt-d-Arg-Phe-Lys-NH(2) to the potent delta antagonist H-Dmt-Tic-Phe-Lys(Z)-OH.

Balboni G, Cocco MT, Salvadori S, Romagnoli R, Sasaki Y, Okada Y, Bryant SD, Jinsmaa Y, Lazarus LH.

J Med Chem. 2005 Aug 25;48(17):5608-11.

PMID:
16107162

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