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Items: 1 to 20 of 28

1.

The Glycogen Synthase Kinase-3β Inhibitor LSN 2105786 Promotes Zebrafish Fin Regeneration.

Sarmah S, Curtis C, Mahin J, Farrell M, Engler TA, Sanchez-Felix MV, Sato M, Ma YL, Chu S, Marrs JA.

Biomedicines. 2019 Apr 19;7(2). pii: E30. doi: 10.3390/biomedicines7020030.

2.

Aurora A Kinase Inhibition Is Synthetic Lethal with Loss of the RB1 Tumor Suppressor Gene.

Gong X, Du J, Parsons SH, Merzoug FF, Webster Y, Iversen PW, Chio LC, Van Horn RD, Lin X, Blosser W, Han B, Jin S, Yao S, Bian H, Ficklin C, Fan L, Kapoor A, Antonysamy S, Mc Nulty AM, Froning K, Manglicmot D, Pustilnik A, Weichert K, Wasserman SR, Dowless M, Marugán C, Baquero C, Lallena MJ, Eastman SW, Hui YH, Dieter MZ, Doman T, Chu S, Qian HR, Ye XS, Barda DA, Plowman GD, Reinhard C, Campbell RM, Henry JR, Buchanan SG.

Cancer Discov. 2019 Feb;9(2):248-263. doi: 10.1158/2159-8290.CD-18-0469. Epub 2018 Oct 29.

PMID:
30373917
3.

Genomic Aberrations that Activate D-type Cyclins Are Associated with Enhanced Sensitivity to the CDK4 and CDK6 Inhibitor Abemaciclib.

Gong X, Litchfield LM, Webster Y, Chio LC, Wong SS, Stewart TR, Dowless M, Dempsey J, Zeng Y, Torres R, Boehnke K, Mur C, Marugán C, Baquero C, Yu C, Bray SM, Wulur IH, Bi C, Chu S, Qian HR, Iversen PW, Merzoug FF, Ye XS, Reinhard C, De Dios A, Du J, Caldwell CW, Lallena MJ, Beckmann RP, Buchanan SG.

Cancer Cell. 2017 Dec 11;32(6):761-776.e6. doi: 10.1016/j.ccell.2017.11.006.

4.

Repurposing a novel parathyroid hormone analogue to treat hypoparathyroidism.

Krishnan V, Ma YL, Chen CZ, Thorne N, Bullock H, Tawa G, Javella-Cauley C, Chu S, Li W, Kohn W, Adrian MD, Benson C, Liu L, Sato M, Zheng W, Pilon AM, Yang NN, Bryant HU.

Br J Pharmacol. 2018 Jan;175(2):262-271. doi: 10.1111/bph.14028. Epub 2017 Nov 28.

5.

Inhibition of CXCR4 by LY2624587, a Fully Humanized Anti-CXCR4 Antibody Induces Apoptosis of Hematologic Malignancies.

Peng SB, Zhang X, Paul D, Kays LM, Ye M, Vaillancourt P, Dowless M, Stancato LF, Stewart J, Uhlik MT, Long H, Chu S, Obungu VH.

PLoS One. 2016 Mar 8;11(3):e0150585. doi: 10.1371/journal.pone.0150585. eCollection 2016.

6.

Novel Phenotypic Outcomes Identified for a Public Collection of Approved Drugs from a Publicly Accessible Panel of Assays.

Lee JA, Shinn P, Jaken S, Oliver S, Willard FS, Heidler S, Peery RB, Oler J, Chu S, Southall N, Dexheimer TS, Smallwood J, Huang R, Guha R, Jadhav A, Cox K, Austin CP, Simeonov A, Sittampalam GS, Husain S, Franklin N, Wild DJ, Yang JJ, Sutherland JJ, Thomas CJ.

PLoS One. 2015 Jul 15;10(7):e0130796. doi: 10.1371/journal.pone.0130796. eCollection 2015.

7.

Generation and activity of a humanized monoclonal antibody that selectively neutralizes the epidermal growth factor receptor ligands transforming growth factor-α and epiregulin.

Beidler CB, Petrovan RJ, Conner EM, Boyles JS, Yang DD, Harlan SM, Chu S, Ellis B, Datta-Mannan A, Johnson RL, Stauber A, Witcher DR, Breyer MD, Heuer JG.

J Pharmacol Exp Ther. 2014 May;349(2):330-43. doi: 10.1124/jpet.113.210765. Epub 2014 Feb 11.

PMID:
24518034
8.

Multiparametric cell-based assay for the evaluation of transcription inhibition by high-content imaging.

Torres-Guzmán R, Chu S, Velasco JA, Lallena MJ.

J Biomol Screen. 2013 Jun;18(5):556-66. doi: 10.1177/1087057112472539. Epub 2013 Jan 10.

PMID:
23307837
9.

Open innovation for phenotypic drug discovery: The PD2 assay panel.

Lee JA, Chu S, Willard FS, Cox KL, Sells Galvin RJ, Peery RB, Oliver SE, Oler J, Meredith TD, Heidler SA, Gough WH, Husain S, Palkowitz AD, Moxham CM.

J Biomol Screen. 2011 Jul;16(6):588-602. doi: 10.1177/1087057111405379. Epub 2011 Apr 26.

PMID:
21521801
10.

Cdk1 activity is required for mitotic activation of aurora A during G2/M transition of human cells.

Van Horn RD, Chu S, Fan L, Yin T, Du J, Beckmann R, Mader M, Zhu G, Toth J, Blanchard K, Ye XS.

J Biol Chem. 2010 Jul 9;285(28):21849-57. doi: 10.1074/jbc.M110.141010. Epub 2010 May 5.

11.

Dynamic assessment of mitoxantrone resistance and modulation of multidrug resistance by valspodar (PSC833) in multidrug resistance human cancer cells.

Shen F, Bailey BJ, Chu S, Bence AK, Xue X, Erickson P, Safa AR, Beck WT, Erickson LC.

J Pharmacol Exp Ther. 2009 Aug;330(2):423-9. doi: 10.1124/jpet.109.153551. Epub 2009 May 7.

12.

Rapid and quantitative detection of p38 kinase pathway in mouse blood monocyte.

Zhao J, Evans G, Li W, Green L, Chu S, Marder P, Na S.

In Vitro Cell Dev Biol Anim. 2008 May-Jun;44(5-6):145-53. doi: 10.1007/s11626-008-9088-y. Epub 2008 Apr 9.

PMID:
18398666
13.

AGPAT6 is a novel microsomal glycerol-3-phosphate acyltransferase.

Chen YQ, Kuo MS, Li S, Bui HH, Peake DA, Sanders PE, Thibodeaux SJ, Chu S, Qian YW, Zhao Y, Bredt DS, Moller DE, Konrad RJ, Beigneux AP, Young SG, Cao G.

J Biol Chem. 2008 Apr 11;283(15):10048-57. doi: 10.1074/jbc.M708151200. Epub 2008 Jan 31.

14.

Quantitation of doxorubicin uptake, efflux, and modulation of multidrug resistance (MDR) in MDR human cancer cells.

Shen F, Chu S, Bence AK, Bailey B, Xue X, Erickson PA, Montrose MH, Beck WT, Erickson LC.

J Pharmacol Exp Ther. 2008 Jan;324(1):95-102. Epub 2007 Oct 18.

PMID:
17947497
15.

Secreted PCSK9 downregulates low density lipoprotein receptor through receptor-mediated endocytosis.

Qian YW, Schmidt RJ, Zhang Y, Chu S, Lin A, Wang H, Wang X, Beyer TP, Bensch WR, Li W, Ehsani ME, Lu D, Konrad RJ, Eacho PI, Moller DE, Karathanasis SK, Cao G.

J Lipid Res. 2007 Jul;48(7):1488-98. Epub 2007 Apr 20.

16.

Different ionic conditions prompt NHE2 and NHE3 translocation to the plasma membrane.

Gens JS, Du H, Tackett L, Kong SS, Chu S, Montrose MH.

Biochim Biophys Acta. 2007 May;1768(5):1023-35. Epub 2007 Jan 12.

17.

Expression of canonical transient receptor potential (TRPC) proteins in human glomerular mesangial cells.

Sours S, Du J, Chu S, Ding M, Zhou XJ, Ma R.

Am J Physiol Renal Physiol. 2006 Jun;290(6):F1507-15. Epub 2006 Jan 17.

18.

Epithelial barrier function in vivo is sustained despite gaps in epithelial layers.

Watson AJ, Chu S, Sieck L, Gerasimenko O, Bullen T, Campbell F, McKenna M, Rose T, Montrose MH.

Gastroenterology. 2005 Sep;129(3):902-12.

PMID:
16143130
19.

Differential expression and comparative subcellular localization of estrogen receptor beta isoforms in virally transformed and normal cultured human lens epithelial cells.

Cammarata PR, Flynn J, Gottipati S, Chu S, Dimitrijevich S, Younes M, Skliris G, Murphy LC.

Exp Eye Res. 2005 Aug;81(2):165-75.

PMID:
16080910
20.

Hypertonic upregulation of betaine transport in renal cells is blocked by a proteasome inhibitor.

Lammers PE, Beck JA, Chu S, Kempson SA.

Cell Biochem Funct. 2005 Sep-Oct;23(5):315-24.

PMID:
15945068

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