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Items: 1 to 20 of 26

1.

The Flavonoid Metabolite 2,4,6-Trihydroxybenzoic Acid Is a CDK Inhibitor and an Anti-Proliferative Agent: A Potential Role in Cancer Prevention.

Sankaranarayanan R, Valiveti CK, Kumar DR, Van Slambrouck S, Kesharwani SS, Seefeldt T, Scaria J, Tummala H, Bhat GJ.

Cancers (Basel). 2019 Mar 26;11(3). pii: E427. doi: 10.3390/cancers11030427.

2.

5,6,7,3',4',5'-Hexamethoxyflavone inhibits growth of triple-negative breast cancer cells via suppression of MAPK and Akt signaling pathways and arresting cell cycle.

Borah N, Gunawardana S, Torres H, McDonnell S, Van Slambrouck S.

Int J Oncol. 2017 Dec;51(6):1685-1693. doi: 10.3892/ijo.2017.4157. Epub 2017 Oct 13.

3.

FAK tyrosine 407 organized with integrin αVβ5 in Hs578Ts(i)8 advanced triple-negative breast cancer cells.

Payan I, McDonnell S, Torres HM, Steelant WF, Van Slambrouck S.

Int J Oncol. 2016 May;48(5):2043-54. doi: 10.3892/ijo.2016.3422. Epub 2016 Mar 7.

PMID:
26984508
4.

Carbohydrate-to-carbohydrate interactions between α2,3-linked sialic acids on α2 integrin subunits and asialo-GM1 underlie the bone metastatic behaviour of LNCAP-derivative C4-2B prostate cancer cells.

Van Slambrouck S, Groux-Degroote S, Krzewinski-Recchi MA, Cazet A, Delannoy P, Steelant WF.

Biosci Rep. 2014 Sep 17;34(5). pii: e00138. doi: 10.1042/BSR20140096.

5.

1-O-octadecyl-2-O-methylglycero-3-phosphocholine (Edelfosine) and cancer cell invasion: a short review.

Van Slambrouck S, Steelant WF.

Anticancer Agents Med Chem. 2014 May;14(4):539-44. Review.

PMID:
24628232
6.

Structural simplification of bioactive natural products with multicomponent synthesis. 4. 4H-pyrano-[2,3-b]naphthoquinones with anticancer activity.

Magedov IV, Kireev AS, Jenkins AR, Evdokimov NM, Lima DT, Tongwa P, Altig J, Steelant WF, Van slambrouck S, Antipin MY, Kornienko A.

Bioorg Med Chem Lett. 2012 Aug 15;22(16):5195-8. doi: 10.1016/j.bmcl.2012.06.073. Epub 2012 Jul 4.

7.

Anticancer properties of an important drug lead podophyllotoxin can be efficiently mimicked by diverse heterocyclic scaffolds accessible via one-step synthesis.

Magedov IV, Frolova L, Manpadi M, Bhoga Ud, Tang H, Evdokimov NM, George O, Georgiou KH, Renner S, Getlik M, Kinnibrugh TL, Fernandes MA, Van slambrouck S, Steelant WF, Shuster CB, Rogelj S, van Otterlo WA, Kornienko A.

J Med Chem. 2011 Jun 23;54(12):4234-46. doi: 10.1021/jm200410r. Epub 2011 May 26.

8.

Structural simplification of bioactive natural products with multicomponent synthesis. 3. Fused uracil-containing heterocycles as novel topoisomerase-targeting agents.

Evdokimov NM, Van Slambrouck S, Heffeter P, Tu L, Le Calvé B, Lamoral-Theys D, Hooten CJ, Uglinskii PY, Rogelj S, Kiss R, Steelant WF, Berger W, Yang JJ, Bologa CG, Kornienko A, Magedov IV.

J Med Chem. 2011 Apr 14;54(7):2012-21. doi: 10.1021/jm1009428. Epub 2011 Mar 9.

9.

Inhibitory effects of ethacrynic acid analogues lacking the α,β-unsaturated carbonyl unit and para-acylated phenols on human cancer cells.

Bryant ZE, Janser RF, Jabarkhail M, Candelaria-Lyons MS, Romero BB, Van slambrouck S, Steelant WF, Janser I.

Bioorg Med Chem Lett. 2011 Feb 1;21(3):912-5. doi: 10.1016/j.bmcl.2010.12.074. Epub 2010 Dec 19.

10.

In vitro anticancer activity of Anemopsis californica.

Kaminski CN, Ferrey SL, Lowrey T, Guerra L, VAN Slambrouck S, Steelant WF.

Oncol Lett. 2010 Jul;1(4):711-715.

11.

Ethacrynic acid analogues lacking the alpha,beta-unsaturated carbonyl unit--potential anti-metastatic drugs.

Janser RF, Meka RK, Bryant ZE, Adogla EA, Vogel EK, Wharton JL, Tilley CM, Kaminski CN, Ferrey SL, Van Slambrouck S, Steelant WF, Janser I.

Bioorg Med Chem Lett. 2010 Mar 15;20(6):1848-50. doi: 10.1016/j.bmcl.2010.01.144. Epub 2010 Feb 2.

12.

AsialoGM1 and integrin alpha2beta1 mediate prostate cancer progression.

Van Slambrouck S, Hilkens J, Bisoffi M, Steelant WF.

Int J Oncol. 2009 Oct;35(4):693-9.

13.

Reorganization of the integrin alpha2 subunit controls cell adhesion and cancer cell invasion in prostate cancer.

Van Slambrouck S, Jenkins AR, Romero AE, Steelant WF.

Int J Oncol. 2009 Jun;34(6):1717-26.

14.

Biological evaluation of structurally diverse amaryllidaceae alkaloids and their synthetic derivatives: discovery of novel leads for anticancer drug design.

Evidente A, Kireev AS, Jenkins AR, Romero AE, Steelant WF, Van Slambrouck S, Kornienko A.

Planta Med. 2009 Apr;75(5):501-7. doi: 10.1055/s-0029-1185340. Epub 2009 Feb 23.

15.

Evaluation of aqueous extracts of Taraxacum officinale on growth and invasion of breast and prostate cancer cells.

Sigstedt SC, Hooten CJ, Callewaert MC, Jenkins AR, Romero AE, Pullin MJ, Kornienko A, Lowrey TK, Slambrouck SV, Steelant WF.

Int J Oncol. 2008 May;32(5):1085-90.

PMID:
18425335
16.

Structural simplification of bioactive natural products with multicomponent synthesis. 2. antiproliferative and antitubulin activities of pyrano[3,2-c]pyridones and pyrano[3,2-c]quinolones.

Magedov IV, Manpadi M, Ogasawara MA, Dhawan AS, Rogelj S, Van Slambrouck S, Steelant WF, Evdokimov NM, Uglinskii PY, Elias EM, Knee EJ, Tongwa P, Antipin MY, Kornienko A.

J Med Chem. 2008 Apr 24;51(8):2561-70. doi: 10.1021/jm701499n. Epub 2008 Mar 25.

17.

Novel three-component synthesis and antiproliferative properties of diversely functionalized pyrrolines.

Magedov IV, Luchetti G, Evdokimov NM, Manpadi M, Steelant WF, Van Slambrouck S, Tongwa P, Antipin MY, Kornienko A.

Bioorg Med Chem Lett. 2008 Feb 15;18(4):1392-6. doi: 10.1016/j.bmcl.2008.01.019. Epub 2008 Jan 11.

19.

Three-component synthesis and anticancer evaluation of polycyclic indenopyridines lead to the discovery of a novel indenoheterocycle with potent apoptosis inducing properties.

Manpadi M, Uglinskii PY, Rastogi SK, Cotter KM, Wong YS, Anderson LA, Ortega AJ, Van Slambrouck S, Steelant WF, Rogelj S, Tongwa P, Antipin MY, Magedov IV, Kornienko A.

Org Biomol Chem. 2007 Dec 7;5(23):3865-72. Epub 2007 Oct 24.

PMID:
18004468
20.

Activation of the FAK-src molecular scaffolds and p130Cas-JNK signaling cascades by alpha1-integrins during colon cancer cell invasion.

Van Slambrouck S, Grijelmo C, De Wever O, Bruyneel E, Emami S, Gespach C, Steelant WF.

Int J Oncol. 2007 Dec;31(6):1501-8.

PMID:
17982677

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