Format

Send to

Choose Destination
Materials (Basel). 2019 May 19;12(10). pii: E1635. doi: 10.3390/ma12101635.

Tuning the Hydrophobicity of a Hydrogel Using Self-Assembled Domains of Polymer Cross-Linkers.

Author information

1
Department of Chemical Engineering, Soongsil University, 369, Sangdo-Ro, Dongjak-Gu, Seoul 06978, Korea. kimhj0706@ssu.ac.kr.
2
Department of Chemical Engineering, Soongsil University, 369, Sangdo-Ro, Dongjak-Gu, Seoul 06978, Korea. som113@ssu.ac.kr.
3
Department of Chemical Engineering, Soongsil University, 369, Sangdo-Ro, Dongjak-Gu, Seoul 06978, Korea. ohsj0610@ssu.ac.kr.
4
Department of Chemical Engineering, Soongsil University, 369, Sangdo-Ro, Dongjak-Gu, Seoul 06978, Korea. whitegd45@ssu.ac.kr.
5
Department of Chemical Engineering, Soongsil University, 369, Sangdo-Ro, Dongjak-Gu, Seoul 06978, Korea. hwryu@ssu.ac.kr.
6
Department of Chemical Engineering, Soongsil University, 369, Sangdo-Ro, Dongjak-Gu, Seoul 06978, Korea. nfejjh@ssu.ac.kr.

Abstract

Hydrogels incorporated with hydrophobic motifs have received considerable attention to recapitulate the cellular microenvironments, specifically for the bio-mineralization of a 3D matrix. Introduction of hydrophobic molecules into a hydrogel often results in irregular arrangement of the motifs, and further phase separation of hydrophobic domains, but limited efforts have been made to resolve this challenge in developing the hydrophobically-modified hydrogel. Therefore, this study presents an advanced integrative strategy to incorporate hydrophobic domains regularly in a hydrogel using self-assembled domains formed with polymer cross-linkers, building blocks of a hydrogel. Self-assemblies formed by polymer cross-linkers were examined as micro-domains to incorporate hydrophobic motifs in a hydrogel. The self-assembled structures in a pre-gelled solution were confirmed with the fluorescence analysis and the hydrophobicity of a hydrogel could be tuned by incorporating the hydrophobic chains in a controlled manner. Overall, the results of this study would greatly serve to tuning performance of a wide array of hydrophobically-modified hydrogels in drug delivery, cell therapies and tissue engineering.

KEYWORDS:

degree of swelling; hydrogel; hydrophobicity; self-assembly

Supplemental Content

Full text links

Icon for Multidisciplinary Digital Publishing Institute (MDPI) Icon for PubMed Central
Loading ...
Support Center