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Items: 1 to 20 of 177

1.

Tellurides Bearing Sulfonamides as Novel Inhibitors of Leishmanial Carbonic Anhydrase with Potent Antileishmanial Activity.

Angeli A, Mitxeltorena ME, Sanmartin C, Espuelas S, Azqueta A, Parkkila S, Carta F, Supuran CT, Moreno Amatria E.

J Med Chem. 2020 Mar 29. doi: 10.1021/acs.jmedchem.0c00211. [Epub ahead of print]

PMID:
32223141
2.

Design, synthesis, in vitro inhibition and toxicological evaluation of human carbonic anhydrases I, II and IX inhibitors in 5-nitroimidazole series.

Aspatwar A, Parvathaneni NK, Barker H, Anduran E, Supuran CT, Dubois L, Lambin P, Parkkila S, Winum JY.

J Enzyme Inhib Med Chem. 2020 Dec;35(1):109-117. doi: 10.1080/14756366.2019.1685510.

3.

In vitro inhibition of Mycobacterium tuberculosis β-carbonic anhydrase 3 with Mono- and dithiocarbamates and evaluation of their toxicity using zebrafish developing embryos.

Aspatwar A, Hammaren M, Parikka M, Parkkila S, Carta F, Bozdag M, Vullo D, Supuran CT.

J Enzyme Inhib Med Chem. 2020 Dec;35(1):65-71. doi: 10.1080/14756366.2019.1683007.

4.

Mycobacterium tuberculosis β-Carbonic Anhydrases: Novel Targets for Developing Antituberculosis Drugs.

Aspatwar A, Kairys V, Rala S, Parikka M, Bozdag M, Carta F, Supuran CT, Parkkila S.

Int J Mol Sci. 2019 Oct 17;20(20). pii: E5153. doi: 10.3390/ijms20205153. Review.

5.

A structure-based approach towards the identification of novel antichagasic compounds: Trypanosoma cruzi carbonic anhydrase inhibitors.

Llanos MA, Sbaraglini ML, Villalba ML, Ruiz MD, Carrillo C, Alba Soto C, Talevi A, Angeli A, Parkkila S, Supuran CT, Gavernet L.

J Enzyme Inhib Med Chem. 2020 Dec;35(1):21-30. doi: 10.1080/14756366.2019.1677638.

6.

Rapid Evaluation of Toxicity of Chemical Compounds Using Zebrafish Embryos.

Aspatwar A, Hammaren MM, Parikka M, Parkkila S.

J Vis Exp. 2019 Aug 25;(150). doi: 10.3791/59315.

PMID:
31498322
7.

Engineered Carbonic Anhydrase VI-Mimic Enzyme Switched the Structure and Affinities of Inhibitors.

Kazokaitė J, Kairys V, Smirnovienė J, Smirnov A, Manakova E, Tolvanen M, Parkkila S, Matulis D.

Sci Rep. 2019 Sep 3;9(1):12710. doi: 10.1038/s41598-019-49094-0.

8.

Phytochemicals as Modulators of Long Non-Coding RNAs and Inhibitors of Cancer-Related Carbonic Anhydrases.

Saghafi T, Taheri RA, Parkkila S, Emameh RZ.

Int J Mol Sci. 2019 Jun 15;20(12). pii: E2939. doi: 10.3390/ijms20122939. Review.

9.

Catalytically inactive carbonic anhydrase-related proteins enhance transport of lactate by MCT1.

Aspatwar A, Tolvanen MEE, Schneider HP, Becker HM, Narkilahti S, Parkkila S, Deitmer JW.

FEBS Open Bio. 2019 Jul;9(7):1204-1211. doi: 10.1002/2211-5463.12647. Epub 2019 Jun 11.

10.

Discovery of new organoselenium compounds as antileishmanial agents.

Al-Tamimi AS, Etxebeste-Mitxeltorena M, Sanmartín C, Jiménez-Ruiz A, Syrjänen L, Parkkila S, Selleri S, Carta F, Angeli A, Supuran CT.

Bioorg Chem. 2019 May;86:339-345. doi: 10.1016/j.bioorg.2019.01.069. Epub 2019 Jan 31.

PMID:
30743174
11.

Activation Studies of the β-Carbonic Anhydrase from the Pathogenic Protozoan Entamoeba histolytica with Amino Acids and Amines.

Bua S, Haapanen S, Kuuslahti M, Parkkila S, Supuran CT.

Metabolites. 2019 Feb 1;9(2). pii: E26. doi: 10.3390/metabo9020026.

12.

Sulfonamide Inhibition Studies of a New β-Carbonic Anhydrase from the Pathogenic Protozoan Entamoeba histolytica.

Bua S, Haapanen S, Kuuslahti M, Parkkila S, Supuran CT.

Int J Mol Sci. 2018 Dec 8;19(12). pii: E3946. doi: 10.3390/ijms19123946.

13.

R-Ras regulates vascular permeability, but not overall healing in skin wounds.

Ketomäki T, Vähätupa M, May U, Pemmari T, Ruikka E, Hietamo J, Kaipiainen P, Barker H, Parkkila S, Uusitalo-Järvinen H, Järvinen TAH.

Exp Dermatol. 2019 Feb;28(2):202-206. doi: 10.1111/exd.13851. Epub 2018 Dec 21.

PMID:
30489650
14.

Cloning, Characterization and Anion Inhibition Studies of a β-Carbonic Anhydrase from the Pathogenic Protozoan Entamoeba histolytica.

Haapanen S, Bua S, Kuuslahti M, Parkkila S, Supuran CT.

Molecules. 2018 Nov 28;23(12). pii: E3112. doi: 10.3390/molecules23123112.

15.

Carbonic Anhydrase Inhibitors as Novel Drugs against Mycobacterial β-Carbonic Anhydrases: An Update on In Vitro and In Vivo Studies.

Aspatwar A, Winum JY, Carta F, Supuran CT, Hammaren M, Parikka M, Parkkila S.

Molecules. 2018 Nov 8;23(11). pii: E2911. doi: 10.3390/molecules23112911. Review.

16.

Toll-like receptors 2, 4 and 9 and hypoxia markers HIF-1alpha and CAIX in pancreatic intraepithelial neoplasia.

Leppänen J, Helminen O, Huhta H, Kauppila JH, Isohookana J, Haapasaari KM, Karihtala P, Parkkila S, Saarnio J, Lehenkari PP, Karttunen TJ.

APMIS. 2018 Nov;126(11):852-863. doi: 10.1111/apm.12894.

PMID:
30357962
17.

Carbonic anhydrases II, IX, and XII in Barrett's esophagus and adenocarcinoma.

Nortunen M, Huhta H, Helminen O, Parkkila S, Kauppila JH, Karttunen TJ, Saarnio J.

Virchows Arch. 2018 Nov;473(5):567-575. doi: 10.1007/s00428-018-2424-z. Epub 2018 Jul 31.

PMID:
30066203
18.

Activation studies with amines and amino acids of the α-carbonic anhydrase from the pathogenic protozoan Trypanosoma cruzi.

Angeli A, Kuuslahti M, Parkkila S, Supuran CT.

Bioorg Med Chem. 2018 Aug 7;26(14):4187-4190. doi: 10.1016/j.bmc.2018.07.011. Epub 2018 Jul 7.

PMID:
30007565
19.

Weak HIF-1alpha expression indicates poor prognosis in resectable pancreatic ductal adenocarcinoma.

Leppänen J, Helminen O, Huhta H, Kauppila JH, Isohookana J, Haapasaari KM, Parkkila S, Saarnio J, Lehenkari PP, Karttunen TJ.

World J Surg Oncol. 2018 Jul 4;16(1):127. doi: 10.1186/s12957-018-1432-4.

20.

Nitroimidazole-based inhibitors DTP338 and DTP348 are safe for zebrafish embryos and efficiently inhibit the activity of human CA IX in Xenopus oocytes.

Aspatwar A, Becker HM, Parvathaneni NK, Hammaren M, Svorjova A, Barker H, Supuran CT, Dubois L, Lambin P, Parikka M, Parkkila S, Winum JY.

J Enzyme Inhib Med Chem. 2018 Dec;33(1):1064-1073. doi: 10.1080/14756366.2018.1482285.

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