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Items: 7


STAT3 and STAT5 Activation in Solid Cancers.

Igelmann S, Neubauer HA, Ferbeyre G.

Cancers (Basel). 2019 Sep 25;11(10). pii: E1428. doi: 10.3390/cancers11101428. Review.


Ribosomal protein RPL22/eL22 regulates the cell cycle by acting as an inhibitor of the CDK4-cyclin D complex.

Del Toro N, Fernandez-Ruiz A, Mignacca L, Kalegari P, Rowell MC, Igelmann S, Saint-Germain E, Benfdil M, Lopes-Paciencia S, Brakier-Gingras L, Bourdeau V, Ferbeyre G, Lessard F.

Cell Cycle. 2019 Mar - Apr;18(6-7):759-770. doi: 10.1080/15384101.2019.1593708. Epub 2019 Mar 28.


Circumventing senescence is associated with stem cell properties and metformin sensitivity.

Deschênes-Simard X, Parisotto M, Rowell MC, Le Calvé B, Igelmann S, Moineau-Vallée K, Saint-Germain E, Kalegari P, Bourdeau V, Kottakis F, Bardeesy N, Ferbeyre G.

Aging Cell. 2019 Apr;18(2):e12889. doi: 10.1111/acel.12889. Epub 2019 Jan 6.


Senescence-associated ribosome biogenesis defects contributes to cell cycle arrest through the Rb pathway.

Lessard F, Igelmann S, Trahan C, Huot G, Saint-Germain E, Mignacca L, Del Toro N, Lopes-Paciencia S, Le Calvé B, Montero M, Deschênes-Simard X, Bury M, Moiseeva O, Rowell MC, Zorca CE, Zenklusen D, Brakier-Gingras L, Bourdeau V, Oeffinger M, Ferbeyre G.

Nat Cell Biol. 2018 Jul;20(7):789-799. doi: 10.1038/s41556-018-0127-y. Epub 2018 Jun 25.


Senescence gives insights into the morphogenetic evolution of anamniotes.

Villiard É, Denis JF, Hashemi FS, Igelmann S, Ferbeyre G, Roy S.

Biol Open. 2017 Jun 15;6(6):891-896. doi: 10.1242/bio.025809.


Tumor suppressor activity of the ERK/MAPK pathway by promoting selective protein degradation.

Deschênes-Simard X, Gaumont-Leclerc MF, Bourdeau V, Lessard F, Moiseeva O, Forest V, Igelmann S, Mallette FA, Saba-El-Leil MK, Meloche S, Saad F, Mes-Masson AM, Ferbeyre G.

Genes Dev. 2013 Apr 15;27(8):900-15. doi: 10.1101/gad.203984.112. Epub 2013 Apr 18.


Metformin inhibits the senescence-associated secretory phenotype by interfering with IKK/NF-κB activation.

Moiseeva O, Deschênes-Simard X, St-Germain E, Igelmann S, Huot G, Cadar AE, Bourdeau V, Pollak MN, Ferbeyre G.

Aging Cell. 2013 Jun;12(3):489-98. doi: 10.1111/acel.12075. Epub 2013 Apr 23.

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