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Items: 1 to 20 of 34

1.

Human mitochondrial carnitine acylcarnitine carrier: Molecular target of dietary bioactive polyphenols from sweet cherry (Prunus avium L.).

Console L, Giangregorio N, Cellamare S, Bolognino I, Palasciano M, Indiveri C, Incampo G, Campana S, Tonazzi A.

Chem Biol Interact. 2019 Jul 1;307:179-185. doi: 10.1016/j.cbi.2019.05.006. Epub 2019 May 4.

PMID:
31063765
2.

1,2,3,4-Tetrahydroisoquinoline/2H-chromen-2-one conjugates as nanomolar P-glycoprotein inhibitors: Molecular determinants for affinity and selectivity over multidrug resistance associated protein 1.

Rullo M, Niso M, Pisani L, Carrieri A, Colabufo NA, Cellamare S, Altomare CD.

Eur J Med Chem. 2019 Jan 1;161:433-444. doi: 10.1016/j.ejmech.2018.10.043. Epub 2018 Oct 18.

PMID:
30384046
3.

Investigating alkyl nitrates as nitric oxide releasing precursors of multitarget acetylcholinesterase-monoamine oxidase B inhibitors.

Pisani L, Iacobazzi RM, Catto M, Rullo M, Farina R, Denora N, Cellamare S, Altomare CD.

Eur J Med Chem. 2019 Jan 1;161:292-309. doi: 10.1016/j.ejmech.2018.10.016. Epub 2018 Oct 10.

PMID:
30366255
4.

Novel bisphosphonates with antiresorptive effect in bone mineralization and osteoclastogenesis.

Savino S, Toscano A, Purgatorio R, Profilo E, Laghezza A, Tortorella P, Angelelli M, Cellamare S, Scala R, Tricarico D, Marobbio CMT, Perna F, Vitale P, Agamennone M, Dimiccoli V, Tolomeo A, Scilimati A.

Eur J Med Chem. 2018 Oct 5;158:184-200. doi: 10.1016/j.ejmech.2018.08.044. Epub 2018 Aug 18.

PMID:
30216851
5.

Insights into Structure-Activity Relationships of 3-Arylhydrazonoindolin-2-One Derivatives for Their Multitarget Activity on β-Amyloid Aggregation and Neurotoxicity.

Purgatorio R, de Candia M, De Palma A, De Santis F, Pisani L, Campagna F, Cellamare S, Altomare CD, Catto M.

Molecules. 2018 Jun 26;23(7). pii: E1544. doi: 10.3390/molecules23071544.

6.

A New Class of 1-Aryl-5,6-dihydropyrrolo[2,1-a]isoquinoline Derivatives as Reversers of P-Glycoprotein-Mediated Multidrug Resistance in Tumor Cells.

Nevskaya AA, Matveeva MD, Borisova TN, Niso M, Colabufo NA, Boccarelli A, Purgatorio R, de Candia M, Cellamare S, Voskressensky LG, Altomare CD.

ChemMedChem. 2018 Aug 10;13(15):1588-1596. doi: 10.1002/cmdc.201800177. Epub 2018 Jul 4.

PMID:
29802687
7.

Structure-property relationship study of the HPLC enantioselective retention of neuroprotective 7-[(1-alkylpiperidin-3-yl)methoxy]coumarin derivatives on an amylose-based chiral stationary phase.

Pisani L, Rullo M, Catto M, de Candia M, Carrieri A, Cellamare S, Altomare CD.

J Sep Sci. 2018 Mar;41(6):1376-1384. doi: 10.1002/jssc.201701442.

PMID:
29419937
8.

Investigating Structural Requirements for the Antiproliferative Activity of Biphenyl Nicotinamides.

Majellaro M, Stefanachi A, Tardia P, Vicenti C, Boccarelli A, Pannunzio A, Campanella F, Coluccia M, Denora N, Leonetti F, de Candia M, Altomare CD, Cellamare S.

ChemMedChem. 2017 Aug 22;12(16):1380-1389. doi: 10.1002/cmdc.201700365. Epub 2017 Aug 3.

PMID:
28665505
9.

Discovery of Potent Dual Binding Site Acetylcholinesterase Inhibitors via Homo- and Heterodimerization of Coumarin-Based Moieties.

Pisani L, Catto M, De Palma A, Farina R, Cellamare S, Altomare CD.

ChemMedChem. 2017 Aug 22;12(16):1349-1358. doi: 10.1002/cmdc.201700282. Epub 2017 Jun 29.

PMID:
28570763
10.

Design, synthesis, biological evaluation, NMR and DFT studies of structurally simplified trimethoxy benzamides as selective P-glycoprotein inhibitors: the role of molecular flatness.

Stefanachi A, Mangiatordi GF, Tardia P, Alberga D, Leonetti F, Niso M, Colabufo NA, Adamo C, Nicolotti O, Cellamare S.

Chem Biol Drug Des. 2016 Dec;88(6):820-831. doi: 10.1111/cbdd.12811. Epub 2016 Jul 26.

PMID:
27331911
11.

Pharmaceutical development of novel lactate-based 6-fluoro-l-DOPA formulations.

Denora N, Lopedota A, de Candia M, Cellamare S, Degennaro L, Luisi R, Mele A, Tricarico D, Cutrignelli A, Laquintana V, Altomare CD, Franco M, Dimiccoli V, Tolomeo A, Scilimati A.

Eur J Pharm Sci. 2017 Mar 1;99:361-368. doi: 10.1016/j.ejps.2016.10.001. Epub 2016 Oct 4.

PMID:
27717874
12.

New azepino[4,3-b]indole derivatives as nanomolar selective inhibitors of human butyrylcholinesterase showing protective effects against NMDA-induced neurotoxicity.

de Candia M, Zaetta G, Denora N, Tricarico D, Majellaro M, Cellamare S, Altomare CD.

Eur J Med Chem. 2017 Jan 5;125:288-298. doi: 10.1016/j.ejmech.2016.09.037. Epub 2016 Sep 13.

PMID:
27688184
13.

Mind the Gap! A Journey towards Computational Toxicology.

Mangiatordi GF, Alberga D, Altomare CD, Carotti A, Catto M, Cellamare S, Gadaleta D, Lattanzi G, Leonetti F, Pisani L, Stefanachi A, Trisciuzzi D, Nicolotti O.

Mol Inform. 2016 Sep;35(8-9):294-308. doi: 10.1002/minf.201501017. Epub 2016 Apr 13. Review.

PMID:
27546034
14.

Exploring Basic Tail Modifications of Coumarin-Based Dual Acetylcholinesterase-Monoamine Oxidase B Inhibitors: Identification of Water-Soluble, Brain-Permeant Neuroprotective Multitarget Agents.

Pisani L, Farina R, Catto M, Iacobazzi RM, Nicolotti O, Cellamare S, Mangiatordi GF, Denora N, Soto-Otero R, Siragusa L, Altomare CD, Carotti A.

J Med Chem. 2016 Jul 28;59(14):6791-806. doi: 10.1021/acs.jmedchem.6b00562. Epub 2016 Jul 7.

PMID:
27347731
15.

Docking-based classification models for exploratory toxicology studies on high-quality estrogenic experimental data.

Trisciuzzi D, Alberga D, Mansouri K, Judson R, Cellamare S, Catto M, Carotti A, Benfenati E, Novellino E, Mangiatordi GF, Nicolotti O.

Future Med Chem. 2015;7(14):1921-36. doi: 10.4155/fmc.15.103. Epub 2015 Oct 6.

PMID:
26440057
16.

Galloyl benzamide-based compounds modulating tumour necrosis factor α-stimulated c-Jun N-terminal kinase and p38 mitogen-activated protein kinase signalling pathways.

Leo V, Stefanachi A, Nacci C, Leonetti F, de Candia M, Carotti A, Altomare CD, Montagnani M, Cellamare S.

J Pharm Pharmacol. 2015 Oct;67(10):1380-92. doi: 10.1111/jphp.12438. Epub 2015 Jun 16.

PMID:
26078032
17.

New organic nitrate-containing benzyloxy isonipecotanilide derivatives with vasodilatory and anti-platelet activity.

de Candia M, Marini E, Zaetta G, Cellamare S, Di Stilo A, Altomare CD.

Eur J Pharm Sci. 2015 May 25;72:69-80. doi: 10.1016/j.ejps.2015.03.004. Epub 2015 Mar 10.

18.

Discovery of new 7-substituted-4-imidazolylmethyl coumarins and 4'-substituted-2-imidazolyl acetophenones open analogues as potent and selective inhibitors of steroid-11β-hydroxylase.

Stefanachi A, Hanke N, Pisani L, Leonetti F, Nicolotti O, Catto M, Cellamare S, Hartmann RW, Carotti A.

Eur J Med Chem. 2015 Jan 7;89:106-14. doi: 10.1016/j.ejmech.2014.10.021. Epub 2014 Oct 13.

PMID:
25462231
19.

Trimethoxybenzanilide-based P-glycoprotein modulators: an interesting case of lipophilicity tuning by intramolecular hydrogen bonding.

Tardia P, Stefanachi A, Niso M, Stolfa DA, Mangiatordi GF, Alberga D, Nicolotti O, Lattanzi G, Carotti A, Leonetti F, Perrone R, Berardi F, Azzariti A, Colabufo NA, Cellamare S.

J Med Chem. 2014 Aug 14;57(15):6403-18. doi: 10.1021/jm500697c. Epub 2014 Aug 5.

PMID:
25093931
20.

Discovery, biological evaluation, and structure-activity and -selectivity relationships of 6'-substituted (E)-2-(benzofuran-3(2H)-ylidene)-N-methylacetamides, a novel class of potent and selective monoamine oxidase inhibitors.

Pisani L, Barletta M, Soto-Otero R, Nicolotti O, Mendez-Alvarez E, Catto M, Introcaso A, Stefanachi A, Cellamare S, Altomare C, Carotti A.

J Med Chem. 2013 Mar 28;56(6):2651-64. doi: 10.1021/jm4000769. Epub 2013 Mar 13.

PMID:
23437843

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