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Items: 1 to 20 of 37


A Comprehensive Diverse '-omics' Approach to Better Understanding the Molecular Pathomechanisms of Down Syndrome.

Ishihara K, Akiba S.

Brain Sci. 2017 Apr 21;7(4). pii: E44. doi: 10.3390/brainsci7040044. Review.


Ts1Cje Down syndrome model mice exhibit environmental stimuli-triggered locomotor hyperactivity and sociability concurrent with increased flux through central dopamine and serotonin metabolism.

Shimohata A, Ishihara K, Hattori S, Miyamoto H, Morishita H, Ornthanalai G, Raveau M, Ebrahim AS, Amano K, Yamada K, Sago H, Akiba S, Mataga N, Murphy NP, Miyakawa T, Yamakawa K.

Exp Neurol. 2017 Jul;293:1-12. doi: 10.1016/j.expneurol.2017.03.009. Epub 2017 Mar 20.


Group IVA phospholipase A(2) deficiency prevents CCl4-induced hepatic cell death through the enhancement of autophagy.

Ishihara K, Kanai S, Tanaka K, Kawashita E, Akiba S.

Biochem Biophys Res Commun. 2016 Feb 26;471(1):15-20. doi: 10.1016/j.bbrc.2016.01.186. Epub 2016 Feb 3.


ASB14780, an Orally Active Inhibitor of Group IVA Phospholipase A2, Is a Pharmacotherapeutic Candidate for Nonalcoholic Fatty Liver Disease.

Kanai S, Ishihara K, Kawashita E, Tomoo T, Nagahira K, Hayashi Y, Akiba S.

J Pharmacol Exp Ther. 2016 Mar;356(3):604-14. doi: 10.1124/jpet.115.229906. Epub 2015 Dec 23.


Production of interleukin (IL)-33 in the lungs during multiple antigen challenge-induced airway inflammation in mice, and its modulation by a glucocorticoid.

Nabe T, Wakamori H, Yano C, Nishiguchi A, Yuasa R, Kido H, Tomiyama Y, Tomoda A, Kida H, Takiguchi A, Matsuda M, Ishihara K, Akiba S, Ohya S, Fukui H, Mizutani N, Yoshino S.

Eur J Pharmacol. 2015 Jun 15;757:34-41. doi: 10.1016/j.ejphar.2015.03.015. Epub 2015 Mar 20.


Effect of a peroxynitrite scavenger, a manganese-porphyrin compound on airway remodeling in a murine asthma.

Cao Y, Fujii M, Ishihara K, Akiba S, Yasui H, Nabe T.

Biol Pharm Bull. 2013;36(5):850-5. Epub 2013 Feb 25.


Group IVA phospholipase A2 participates in the progression of hepatic fibrosis.

Ishihara K, Miyazaki A, Nabe T, Fushimi H, Iriyama N, Kanai S, Sato T, Uozumi N, Shimizu T, Akiba S.

FASEB J. 2012 Oct;26(10):4111-21. doi: 10.1096/fj.12-205625. Epub 2012 Jun 29.


Regulatory role of antigen-induced interleukin-10, produced by CD4(+) T cells, in airway neutrophilia in a murine model for asthma.

Nabe T, Ikedo A, Hosokawa F, Kishima M, Fujii M, Mizutani N, Yoshino S, Ishihara K, Akiba S, Chaplin DD.

Eur J Pharmacol. 2012 Feb 29;677(1-3):154-62. doi: 10.1016/j.ejphar.2011.12.020. Epub 2011 Dec 23.


Regulation of macrophage differentiation and polarization by group IVC phospholipase A₂.

Ishihara K, Kuroda A, Sugihara K, Kanai S, Nabe T, Akiba S.

Biochem Biophys Res Commun. 2011 Dec 16;416(3-4):325-30. doi: 10.1016/j.bbrc.2011.11.034. Epub 2011 Nov 15.


Synthesis of N-(trifluoromethyl-2-pyridinyl)arenesulfonamides as an inhibitor of secretory phospholipase A₂.

Nakayama H, Morita Y, Kimura H, Ishihara K, Akiba S, Uenishi J.

Chem Pharm Bull (Tokyo). 2011;59(6):783-6.


Triacylglycerol deposition with group IVC phospholipase A2 expression in oleate- and linoleate-stimulated Huh-7 hepatocytes.

Ishihara K, Tachibana K, Kuroda A, Terakawa A, Baba S, Kanai S, Akiba S.

Biol Pharm Bull. 2011;34(2):191-6.


Glucose is necessary for stabilization of hypoxia-inducible factor-1alpha under hypoxia: contribution of the pentose phosphate pathway to this stabilization.

Osada-Oka M, Hashiba Y, Akiba S, Imaoka S, Sato T.

FEBS Lett. 2010 Jul 16;584(14):3073-9. doi: 10.1016/j.febslet.2010.05.046. Epub 2010 Jun 1.


Alleviation of high-fat diet-induced fatty liver damage in group IVA phospholipase A2-knockout mice.

Ii H, Yokoyama N, Yoshida S, Tsutsumi K, Hatakeyama S, Sato T, Ishihara K, Akiba S.

PLoS One. 2009 Dec 1;4(12):e8089. doi: 10.1371/journal.pone.0008089.


Hypoxia stimulates the autocrine regulation of migration of vascular smooth muscle cells via HIF-1alpha-dependent expression of thrombospondin-1.

Osada-Oka M, Ikeda T, Akiba S, Sato T.

J Cell Biochem. 2008 Aug 1;104(5):1918-26. doi: 10.1002/jcb.21759.


[Role of thrombospondin-1 in hypoxia-induced migration of human vascular smooth muscle cells].

Takahashi M, Oka M, Ikeda T, Akiba S, Sato T.

Yakugaku Zasshi. 2008 Mar;128(3):377-83. Review. Japanese.


Group IVA phospholipase A2-associated production of MMP-9 in macrophages and formation of atherosclerotic lesions.

Ii H, Hontani N, Toshida I, Oka M, Sato T, Akiba S.

Biol Pharm Bull. 2008 Mar;31(3):363-8.


Group IVA phospholipase A2 is associated with the storage of lipids in adipose tissue and liver.

Ii H, Hatakeyama S, Tsutsumi K, Sato T, Akiba S.

Prostaglandins Other Lipid Mediat. 2008 Jun;86(1-4):12-7. doi: 10.1016/j.prostaglandins.2007.12.002. Epub 2008 Jan 11.


VEGF-enhanced proliferation under hypoxia by an autocrine mechanism in human vascular smooth muscle cells.

Osada-Oka M, Ikeda T, Imaoka S, Akiba S, Sato T.

J Atheroscler Thromb. 2008 Feb;15(1):26-33. Epub 2008 Feb 9.

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