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Items: 1 to 20 of 49

1.

Solenodon genome reveals convergent evolution of venom in eulipotyphlan mammals.

Casewell NR, Petras D, Card DC, Suranse V, Mychajliw AM, Richards D, Koludarov I, Albulescu LO, Slagboom J, Hempel BF, Ngum NM, Kennerley RJ, Brocca JL, Whiteley G, Harrison RA, Bolton FMS, Debono J, Vonk FJ, Alföldi J, Johnson J, Karlsson EK, Lindblad-Toh K, Mellor IR, Süssmuth RD, Fry BG, Kuruppu S, Hodgson WC, Kool J, Castoe TA, Barnes I, Sunagar K, Undheim EAB, Turvey ST.

Proc Natl Acad Sci U S A. 2019 Nov 26. pii: 201906117. doi: 10.1073/pnas.1906117116. [Epub ahead of print]

2.

Impaired l-arginine-nitric oxide pathway contributes to the pathogenesis of resistant hypertension.

Rajapakse NW, Giam B, Kuruppu S, Head GA, Kaye DM.

Clin Sci (Lond). 2019 Oct 30;133(20):2061-2067. doi: 10.1042/CS20190851.

PMID:
31654065
3.

A Taxon-Specific and High-Throughput Method for Measuring Ligand Binding to Nicotinic Acetylcholine Receptors.

Zdenek CN, Harris RJ, Kuruppu S, Youngman NJ, Dobson JS, Debono J, Khan M, Smith I, Yarski M, Harrich D, Sweeney C, Dunstan N, Allen L, Fry BG.

Toxins (Basel). 2019 Oct 16;11(10). pii: E600. doi: 10.3390/toxins11100600.

4.

D. russelii Venom Mediates Vasodilatation of Resistance Like Arteries via Activation of Kv and KCa Channels.

Kakumanu R, Kuruppu S, Rash LD, Isbister GK, Hodgson WC, Kemp-Harper BK.

Toxins (Basel). 2019 Apr 1;11(4). pii: E197. doi: 10.3390/toxins11040197.

5.

Powering Amyloid Beta Degrading Enzymes: A Possible Therapy for Alzheimer's Disease.

Sikanyika NL, Parkington HC, Smith AI, Kuruppu S.

Neurochem Res. 2019 Jun;44(6):1289-1296. doi: 10.1007/s11064-019-02756-x. Epub 2019 Feb 26. Review.

PMID:
30806879
6.

Serelaxin attenuates renal inflammation and fibrosis in a mouse model of dilated cardiomyopathy.

Giam B, Chu PY, Kuruppu S, Smith AI, Horlock D, Murali A, Kiriazis H, Du XJ, Kaye DM, Rajapakse NW.

Exp Physiol. 2018 Dec;103(12):1593-1602. doi: 10.1113/EP087189. Epub 2018 Nov 5.

PMID:
30311699
7.

N-Acetylcysteine Attenuates the Development of Renal Fibrosis in Transgenic Mice with Dilated Cardiomyopathy.

Giam B, Kuruppu S, Chu PY, Smith AI, Marques FZ, Fiedler A, Horlock D, Kiriazis H, Du XJ, Kaye DM, Rajapakse NW.

Sci Rep. 2017 Dec 18;7(1):17718. doi: 10.1038/s41598-017-17927-5.

8.
9.

The characteristics of astrocyte on Aβ clearance altered in Alzheimer's disease were reversed by anti-inflammatory agent (+)-2-(1-hydroxyl-4-oxocyclohexyl) ethyl caffeate.

Kuruppu S, Rajapakse NW, Parkington HC, Smith AI.

Am J Transl Res. 2017 Jul 15;9(7):3514-3516. eCollection 2017. No abstract available.

10.

The Evolution of Fangs, Venom, and Mimicry Systems in Blenny Fishes.

Casewell NR, Visser JC, Baumann K, Dobson J, Han H, Kuruppu S, Morgan M, Romilio A, Weisbecker V, Mardon K, Ali SA, Debono J, Koludarov I, Que I, Bird GC, Cooke GM, Nouwens A, Hodgson WC, Wagstaff SC, Cheney KL, Vetter I, van der Weerd L, Richardson MK, Fry BG.

Curr Biol. 2017 May 22;27(10):1549-1550. doi: 10.1016/j.cub.2017.05.009. No abstract available.

11.

The Evolution of Fangs, Venom, and Mimicry Systems in Blenny Fishes.

Casewell NR, Visser JC, Baumann K, Dobson J, Han H, Kuruppu S, Morgan M, Romilio A, Weisbecker V, Mardon K, Ali SA, Debono J, Koludarov I, Que I, Bird GC, Cooke GM, Nouwens A, Hodgson WC, Wagstaff SC, Cheney KL, Vetter I, van der Weerd L, Richardson MK, Fry BG.

Curr Biol. 2017 Apr 24;27(8):1184-1191. doi: 10.1016/j.cub.2017.02.067. Epub 2017 Mar 30. Erratum in: Curr Biol. 2017 May 22;27(10):1549-1550.

12.

The Cardiovascular and Neurotoxic Effects of the  Venoms of Six Bony and Cartilaginous Fish Species.

Han H, Baumann K, Casewell NR, Ali SA, Dobson J, Koludarov I, Debono J, Cutmore SC, Rajapakse NW, Jackson TN, Jones R, Hodgson WC, Fry BG, Kuruppu S.

Toxins (Basel). 2017 Feb 16;9(2). pii: E67. doi: 10.3390/toxins9020067.

13.

High-Fiber Diet and Acetate Supplementation Change the Gut Microbiota and Prevent the Development of Hypertension and Heart Failure in Hypertensive Mice.

Marques FZ, Nelson E, Chu PY, Horlock D, Fiedler A, Ziemann M, Tan JK, Kuruppu S, Rajapakse NW, El-Osta A, Mackay CR, Kaye DM.

Circulation. 2017 Mar 7;135(10):964-977. doi: 10.1161/CIRCULATIONAHA.116.024545. Epub 2016 Dec 7.

PMID:
27927713
14.

Clinical and Pharmacological Investigation of Myotoxicity in Sri Lankan Russell's Viper (Daboia russelii) Envenoming.

Silva A, Johnston C, Kuruppu S, Kneisz D, Maduwage K, Kleifeld O, Smith AI, Siribaddana S, Buckley NA, Hodgson WC, Isbister GK.

PLoS Negl Trop Dis. 2016 Dec 2;10(12):e0005172. doi: 10.1371/journal.pntd.0005172. eCollection 2016 Dec.

15.

Stimulating the Activity of Amyloid-Beta Degrading Enzymes: A Novel Approach for the Therapeutic Manipulation of Amyloid-Beta Levels.

Kuruppu S, Rajapakse NW, Spicer AJ, Parkington HC, Smith AI.

J Alzheimers Dis. 2016 Oct 4;54(3):891-895. Review.

PMID:
27567865
16.

Effects of Animal Venoms and Toxins on Hallmarks of Cancer.

Chaisakul J, Hodgson WC, Kuruppu S, Prasongsook N.

J Cancer. 2016 Jul 15;7(11):1571-8. doi: 10.7150/jca.15309. eCollection 2016. Review.

17.

Letter by Rajapakse et al Regarding Article, "Combined Angiotensin Receptor Antagonism and Neprilysin Inhibition".

Rajapakse NW, Kuruppu S, Ian Smith A.

Circulation. 2016 Jul 19;134(3):e9-e10. doi: 10.1161/CIRCULATIONAHA.116.023086. No abstract available.

PMID:
27436888
18.

Neurotoxicity in Sri Lankan Russell's Viper (Daboia russelii) Envenoming is Primarily due to U1-viperitoxin-Dr1a, a Pre-Synaptic Neurotoxin.

Silva A, Kuruppu S, Othman I, Goode RJ, Hodgson WC, Isbister GK.

Neurotox Res. 2017 Jan;31(1):11-19. doi: 10.1007/s12640-016-9650-4. Epub 2016 Jul 11.

PMID:
27401825
19.

Canopy Venom: Proteomic Comparison among New World Arboreal Pit-Viper Venoms.

Debono J, Cochran C, Kuruppu S, Nouwens A, Rajapakse NW, Kawasaki M, Wood K, Dobson J, Baumann K, Jouiaei M, Jackson TN, Koludarov I, Low D, Ali SA, Smith AI, Barnes A, Fry BG.

Toxins (Basel). 2016 Jul 8;8(7). pii: E210. doi: 10.3390/toxins8070210.

20.

Effects of Dietary l-Arginine on Nitric Oxide Bioavailability in Obese Normotensive and Obese Hypertensive Subjects.

Giam B, Kuruppu S, Head GA, Kaye DM, Rajapakse NW.

Nutrients. 2016 Jun 14;8(6). pii: E364. doi: 10.3390/nu8060364.

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