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Items: 10


Disease modeling of a mutation in α-actinin 2 guides clinical therapy in hypertrophic cardiomyopathy.

Prondzynski M, Lemoine MD, Zech AT, Horváth A, Di Mauro V, Koivumäki JT, Kresin N, Busch J, Krause T, Krämer E, Schlossarek S, Spohn M, Friedrich FW, Münch J, Laufer SD, Redwood C, Volk AE, Hansen A, Mearini G, Catalucci D, Meyer C, Christ T, Patten M, Eschenhagen T, Carrier L.

EMBO Mol Med. 2019 Dec;11(12):e11115. doi: 10.15252/emmm.201911115. Epub 2019 Nov 3.


Evaluation of MYBPC3 trans-Splicing and Gene Replacement as Therapeutic Options in Human iPSC-Derived Cardiomyocytes.

Prondzynski M, Krämer E, Laufer SD, Shibamiya A, Pless O, Flenner F, Müller OJ, Münch J, Redwood C, Hansen A, Patten M, Eschenhagen T, Mearini G, Carrier L.

Mol Ther Nucleic Acids. 2017 Jun 16;7:475-486. doi: 10.1016/j.omtn.2017.05.008. Epub 2017 May 17.


RNAi revised--target mRNA-dependent enhancement of gene silencing.

Dornseifer S, Willkomm S, Far RK, Liebschwager J, Beltsiou F, Frank K, Laufer SD, Martinetz T, Sczakiel G, Claussen JC, Restle T.

Nucleic Acids Res. 2015 Dec 15;43(22):10623-32. doi: 10.1093/nar/gkv1200. Epub 2015 Nov 17.


MicroRNA-mediated regulation of gene expression is affected by disease-associated SNPs within the 3'-UTR via altered RNA structure.

Haas U, Sczakiel G, Laufer SD.

RNA Biol. 2012 Jun;9(6):924-37. doi: 10.4161/rna.20497. Epub 2012 Jun 1.


Recent developments in peptide-based nucleic acid delivery.

Veldhoen S, Laufer SD, Restle T.

Int J Mol Sci. 2008 Jun;9(7):1276-320. doi: 10.3390/ijms9071276. Epub 2008 Jul 16.


Noncovalent peptide-mediated delivery of chemically modified steric block oligonucleotides promotes splice correction: quantitative analysis of uptake and biological effect.

Laufer SD, Recke AL, Veldhoen S, Trampe A, Restle T.

Oligonucleotides. 2009 Mar;19(1):63-80. doi: 10.1089/oli.2008.0160.


Small molecule inhibitors targeting HIV-1 reverse transcriptase dimerization.

Grohmann D, Corradi V, Elbasyouny M, Baude A, Horenkamp F, Laufer SD, Manetti F, Botta M, Restle T.

Chembiochem. 2008 Apr 14;9(6):916-22. doi: 10.1002/cbic.200700669.


Aptamer displacement identifies alternative small-molecule target sites that escape viral resistance.

Yamazaki S, Tan L, Mayer G, Hartig JS, Song JN, Reuter S, Restle T, Laufer SD, Grohmann D, Kräusslich HG, Bajorath J, Famulok M.

Chem Biol. 2007 Jul;14(7):804-12.


Specific binding of a hexanucleotide to HIV-1 reverse transcriptase: a novel class of bioactive molecules.

Mescalchin A, Wünsche W, Laufer SD, Grohmann D, Restle T, Sczakiel G.

Nucleic Acids Res. 2006;34(19):5631-7. Epub 2006 Oct 12.

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