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Structural analyses of NudT16-ADP-ribose complexes direct rational design of mutants with improved processing of poly(ADP-ribosyl)ated proteins.

Thirawatananond P, McPherson RL, Malhi J, Nathan S, Lambrecht MJ, Brichacek M, Hergenrother PJ, Leung AKL, Gabelli SB.

Sci Rep. 2019 Apr 11;9(1):5940. doi: 10.1038/s41598-019-39491-w.


Ca2+-dependent regulation of sodium channels NaV1.4 and NaV1.5 is controlled by the post-IQ motif.

Yoder JB, Ben-Johny M, Farinelli F, Srinivasan L, Shoemaker SR, Tomaselli GF, Gabelli SB, Amzel LM.

Nat Commun. 2019 Apr 3;10(1):1514. doi: 10.1038/s41467-019-09570-7.


Structural Determinants of Isoform Selectivity in PI3K Inhibitors.

Miller MS, Thompson PE, Gabelli SB.

Biomolecules. 2019 Feb 26;9(3). pii: E82. doi: 10.3390/biom9030082. Review.


Getting the Most Out of Your Crystals: Data Collection at the New High-Flux, Microfocus MX Beamlines at NSLS-II.

Miller MS, Maheshwari S, Shi W, Gao Y, Chu N, Soares AS, Cole PA, Amzel LM, Fuchs MR, Jakoncic J, Gabelli SB.

Molecules. 2019 Jan 30;24(3). pii: E496. doi: 10.3390/molecules24030496.


Diacylglycerol kinases: Relationship to other lipid kinases.

Ma Q, Gabelli SB, Raben DM.

Adv Biol Regul. 2019 Jan;71:104-110. doi: 10.1016/j.jbior.2018.09.014. Epub 2018 Sep 28. Review.


Effects of copper occupancy on the conformational landscape of peptidylglycine α-hydroxylating monooxygenase.

Maheshwari S, Shimokawa C, Rudzka K, Kline CD, Eipper BA, Mains RE, Gabelli SB, Blackburn N, Amzel LM.

Commun Biol. 2018 Jun 25;1:74. doi: 10.1038/s42003-018-0082-y. eCollection 2018.


Akt Kinase Activation Mechanisms Revealed Using Protein Semisynthesis.

Chu N, Salguero AL, Liu AZ, Chen Z, Dempsey DR, Ficarro SB, Alexander WM, Marto JA, Li Y, Amzel LM, Gabelli SB, Cole PA.

Cell. 2018 Aug 9;174(4):897-907.e14. doi: 10.1016/j.cell.2018.07.003. Epub 2018 Aug 2.


Bilobal architecture is a requirement for calmodulin signaling to CaV1.3 channels.

Banerjee R, Yoder JB, Yue DT, Amzel LM, Tomaselli GF, Gabelli SB, Ben-Johny M.

Proc Natl Acad Sci U S A. 2018 Mar 27;115(13):E3026-E3035. doi: 10.1073/pnas.1716381115. Epub 2018 Mar 12.


Nudt19 is a renal CoA diphosphohydrolase with biochemical and regulatory properties that are distinct from the hepatic Nudt7 isoform.

Shumar SA, Kerr EW, Geldenhuys WJ, Montgomery GE, Fagone P, Thirawatananond P, Saavedra H, Gabelli SB, Leonardi R.

J Biol Chem. 2018 Mar 16;293(11):4134-4148. doi: 10.1074/jbc.RA117.001358. Epub 2018 Jan 29.


Intracellular production of hydrogels and synthetic RNA granules by multivalent molecular interactions.

Nakamura H, Lee AA, Afshar AS, Watanabe S, Rho E, Razavi S, Suarez A, Lin YC, Tanigawa M, Huang B, DeRose R, Bobb D, Hong W, Gabelli SB, Goutsias J, Inoue T.

Nat Mater. 2018 Jan;17(1):79-89. doi: 10.1038/nmat5006. Epub 2017 Nov 6.


Corrigendum to "Rapid PD-L1 detection in tumors with PET using a highly specific peptide" [Biochemical and Biophysical Research Communications 483/1 (2017) 258-263].

Chatterjee S, Lesniak WG, Miller MS, Lisok A, Sikorska E, Wharram B, Kumar D, Gabrielson M, Pomper MG, Gabelli SB, Nimmagadda S.

Biochem Biophys Res Commun. 2017 Sep 30;491(4):1125. doi: 10.1016/j.bbrc.2017.08.001. Epub 2017 Aug 8. No abstract available.


Kinetic and structural analyses reveal residues in phosphoinositide 3-kinase α that are critical for catalysis and substrate recognition.

Maheshwari S, Miller MS, O'Meally R, Cole RN, Amzel LM, Gabelli SB.

J Biol Chem. 2017 Aug 18;292(33):13541-13550. doi: 10.1074/jbc.M116.772426. Epub 2017 Jul 4.


A Tunable Brake for HECT Ubiquitin Ligases.

Chen Z, Jiang H, Xu W, Li X, Dempsey DR, Zhang X, Devreotes P, Wolberger C, Amzel LM, Gabelli SB, Cole PA.

Mol Cell. 2017 May 4;66(3):345-357.e6. doi: 10.1016/j.molcel.2017.03.020.


Identification of allosteric binding sites for PI3Kα oncogenic mutant specific inhibitor design.

Miller MS, Maheshwari S, McRobb FM, Kinzler KW, Amzel LM, Vogelstein B, Gabelli SB.

Bioorg Med Chem. 2017 Feb 15;25(4):1481-1486. doi: 10.1016/j.bmc.2017.01.012. Epub 2017 Jan 16.


Rapid PD-L1 detection in tumors with PET using a highly specific peptide.

Chatterjee S, Lesniak WG, Miller MS, Lisok A, Sikorska E, Wharram B, Kumar D, Gabrielson M, Pomper MG, Gabelli SB, Nimmagadda S.

Biochem Biophys Res Commun. 2017 Jan 29;483(1):258-263. doi: 10.1016/j.bbrc.2016.12.156. Epub 2016 Dec 24. Erratum in: Biochem Biophys Res Commun. 2017 Sep 30;491(4):1125.


Kinetic and mutational studies of the adenosine diphosphate ribose hydrolase from Mycobacterium tuberculosis.

O'Handley SF, Thirawatananond P, Kang LW, Cunningham JE, Leyva JA, Amzel LM, Gabelli SB.

J Bioenerg Biomembr. 2016 Dec;48(6):557-567. Epub 2016 Sep 28.


Nudix hydrolases degrade protein-conjugated ADP-ribose.

Daniels CM, Thirawatananond P, Ong SE, Gabelli SB, Leung AK.

Sci Rep. 2015 Dec 16;5:18271. doi: 10.1038/srep18271.


Structural and Enzymatic Characterization of a Nucleoside Diphosphate Sugar Hydrolase from Bdellovibrio bacteriovorus.

de la Peña AH, Suarez A, Duong-Ly KC, Schoeffield AJ, Pizarro-Dupuy MA, Zarr M, Pineiro SA, Amzel LM, Gabelli SB.

PLoS One. 2015 Nov 2;10(11):e0141716. doi: 10.1371/journal.pone.0141716. eCollection 2015.


Calmodulin and Ca(2+) control of voltage gated Na(+) channels.

Gabelli SB, Yoder JB, Tomaselli GF, Amzel LM.

Channels (Austin). 2016;10(1):45-54. doi: 10.1080/19336950.2015.1075677. Epub 2015 Jul 28. Review.


Generation of MANAbodies specific to HLA-restricted epitopes encoded by somatically mutated genes.

Skora AD, Douglass J, Hwang MS, Tam AJ, Blosser RL, Gabelli SB, Cao J, Diaz LA Jr, Papadopoulos N, Kinzler KW, Vogelstein B, Zhou S.

Proc Natl Acad Sci U S A. 2015 Aug 11;112(32):9967-72. doi: 10.1073/pnas.1511996112. Epub 2015 Jul 27.

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