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Items: 1 to 20 of 33


The phosphodiesterase-4 inhibitor roflumilast impacts Schistosoma mansoni ovipositing in vitro but displays only modest antischistosomal activity in vivo.

Botros SS, El-Lakkany NM, Seif El-Din SH, William S, Sabra AN, Hammam OA, de Koning HP.

Exp Parasitol. 2019 Nov 8;208:107793. doi: 10.1016/j.exppara.2019.107793. [Epub ahead of print]


Chemical Profiling of Polyphenolics in Eucalyptus globulus and Evaluation of Its Hepato-Renal Protective Potential Against Cyclophosphamide Induced Toxicity in Mice.

Ghareeb MA, Sobeh M, El-Maadawy WH, Mohammed HS, Khalil H, Botros S, Wink M.

Antioxidants (Basel). 2019 Sep 19;8(9). pii: E415. doi: 10.3390/antiox8090415.


A novel praziquantel solid lipid nanoparticle formulation shows enhanced bioavailability and antischistosomal efficacy against murine S. mansoni infection.

Radwan A, El-Lakkany NM, William S, El-Feky GS, Al-Shorbagy MY, Saleh S, Botros S.

Parasit Vectors. 2019 Jun 17;12(1):304. doi: 10.1186/s13071-019-3563-z.


Antifibrotic effects of gallic acid on hepatic stellate cells: In vitro and in vivo mechanistic study.

El-Lakkany NM, El-Maadawy WH, Seif El-Din SH, Saleh S, Safar MM, Ezzat SM, Mohamed SH, Botros SS, Demerdash Z, Hammam OA.

J Tradit Complement Med. 2018 Apr 27;9(1):45-53. doi: 10.1016/j.jtcme.2018.01.010. eCollection 2019 Jan.


Screening of a PDE-focused library identifies imidazoles with in vitro and in vivo antischistosomal activity.

Botros SS, William S, Sabra AA, El-Lakkany NM, Seif El-Din SH, García-Rubia A, Sebastián-Pérez V, Blaazer AR, de Heuvel E, Sijm M, Zheng Y, Salado IG, Munday JC, Maes L, de Esch IJP, Sterk GJ, Augustyns K, Leurs R, Gil C, De Koning HP.

Int J Parasitol Drugs Drug Resist. 2019 Apr;9:35-43. doi: 10.1016/j.ijpddr.2019.01.001. Epub 2019 Jan 14.


Metabolic profile and hepatoprotective activity of the anthocyanin-rich extract of Hibiscus sabdariffa calyces.

Ezzat SM, Salama MM, Seif El-Din SH, Saleh S, El-Lakkany NM, Hammam OA, Salem MB, Botros SS.

Pharm Biol. 2016 Dec;54(12):3172-3181. Epub 2016 Aug 26.


Resveratrol mitigates hepatic injury in rats by regulating oxidative stress, nuclear factor-kappa B, and apoptosis.

Seif El-Din SH, El-Lakkany NM, Salem MB, Hammam OA, Saleh S, Botros SS.

J Adv Pharm Technol Res. 2016 Jul-Sep;7(3):99-104. doi: 10.4103/2231-4040.184594.


Possible carcinogenic potential of dimethyl dimethoxy biphenyl dicarboxylate in experimental animals.

Botros SS, El-Lakkany NM, Hammam OA, Sabra AN, Taha AA.

J Adv Pharm Technol Res. 2016 Apr-Jun;7(2):54-8. doi: 10.4103/2231-4040.179747.


Bioavailability of paracetamol with/without caffeine in Egyptian patients with hepatitis C virus.

El-Lakkany NM, Hendawy AS, Seif El-Din SH, Ashour AA, Atta R, Abdel-Aziz AA, Mansour AM, Botros SS.

Eur J Clin Pharmacol. 2016 May;72(5):573-82. doi: 10.1007/s00228-016-2025-1. Epub 2016 Feb 18.


Praziquantel in a clay nanoformulation shows more bioavailability and higher efficacy against murine Schistosoma mansoni infection.

El-Feky GS, Mohamed WS, Nasr HE, El-Lakkany NM, Seif El-Din SH, Botros SS.

Antimicrob Agents Chemother. 2015;59(6):3501-8. doi: 10.1128/AAC.04875-14. Epub 2015 Apr 6.


A model for Southern Mediterranean research institute self-assessment: a SWOT analysis-based approach to promote capacity building at Theodor Bilharz Research Institute in Cairo (Egypt).

Ghinolfi D, El Baz HG, Borgonovi E, Radwan A, Laurence O, Sayed HA, De Simone P, Abdelwadoud M, Stefani A, Botros SS, Filipponi F.

Arab J Gastroenterol. 2014 Sep-Dec;15(3-4):92-7. doi: 10.1016/j.ajg.2014.05.003. Epub 2014 Sep 18.


Potential effect of the medicinal plants Calotropis procera, Ficus elastica and Zingiber officinale against Schistosoma mansoni in mice.

Seif el-Din SH, El-Lakkany NM, Mohamed MA, Hamed MM, Sterner O, Botros SS.

Pharm Biol. 2014 Feb;52(2):144-50. doi: 10.3109/13880209.2013.818041. Epub 2013 Sep 19.


Analysis of pan-African Centres of excellence in health innovation highlights opportunities and challenges for local innovation and financing in the continent.

Nwaka S, Ochem A, Besson D, Ramirez B, Fakorede F, Botros S, Inyang U, Mgone C, Adae-Mensah I, Konde V, Nyasse B, Okole B, Guantai A, Loots G, Atadja P, Ndumbe P, Sanou I, Olesen O, Ridley R, Ilunga T.

BMC Int Health Hum Rights. 2012 Jul 27;12:11. doi: 10.1186/1472-698X-12-11.


MCR synthesis of praziquantel derivatives.

Liu H, William S, Herdtweck E, Botros S, Dömling A.

Chem Biol Drug Des. 2012 Apr;79(4):470-7. doi: 10.1111/j.1747-0285.2011.01288.x. Epub 2012 Jan 30.


Efficacy and safety of artemether in the treatment of chronic fascioliasis in Egypt: exploratory phase-2 trials.

Keiser J, Sayed H, el-Ghanam M, Sabry H, Anani S, el-Wakeel A, Hatz C, Utzinger J, el-Din SS, el-Maadawy W, Botros S.

PLoS Negl Trop Dis. 2011 Sep;5(9):e1285. doi: 10.1371/journal.pntd.0001285. Epub 2011 Sep 6.


Comparative efficacy and bioavailability of different praziquantel brands.

Botros S, El-Lakkany N, Seif el-Din SH, Sabra AN, Ibrahim M.

Exp Parasitol. 2011 Feb;127(2):515-21. doi: 10.1016/j.exppara.2010.10.019. Epub 2010 Oct 31.


Praziquantel efficacy in mice infected with PZQ non-susceptible S. mansoni isolate treated with artemether: parasitological, biochemical and immunohistochemical assessment.

Botros SS, Hammam O, Mahmoud M, Bergquist R.

APMIS. 2010 Sep 1;118(9):692-702. doi: 10.1111/j.1600-0463.2010.02645.x.


Antischistosomal activity of hexadecyloxypropyl cyclic 9-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]adenine and other alkoxyalkyl esters of acyclic nucleoside phosphonates assessed by schistosome worm killing in vitro.

Botros SS, William S, Beadle JR, Valiaeva N, Hostetler KY.

Antimicrob Agents Chemother. 2009 Dec;53(12):5284-7. doi: 10.1128/AAC.00840-09. Epub 2009 Aug 24.


The African Network for Drugs and Diagnostics Innovation.

Mboya-Okeyo T, Ridley RG, Nwaka S; ANDI Task Force.

Lancet. 2009 May 2;373(9674):1507-8. doi: 10.1016/S0140-6736(09)60838-2. No abstract available.


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