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Molecules. 2019 May 22;24(10). pii: E1969. doi: 10.3390/molecules24101969.

An Eco-Friendly Technique: Solvent-Free Microwave Synthesis and Docking Studies of Some New Pyridine Nucleosides and Their Pharmacological Significance.

Author information

1
Department of Pharmaceutics and Pharmaceutical Technology, College of Pharmacy, Taif University, Taif 5700, Saudi Arabia. majed.alrobaian@hotmail.co.uk.
2
Department of Information Technology, College of Computers and Information Technology, Taif University, Taif 5700, Saudi Arabia. SANA.ALAZWARI@HOTMAIL.CO.UK.
3
Department of Pharmaceutical Chemistry, College of Pharmacy, Taif University, Taif 5700, Saudi Arabia. abilalmoh1@yahoo.com.
4
Department of Medicinal chemistry, Faculty of Pharmacy, Beni-Suef University, Beni-Suef 1441, Egypt. abilalmoh1@yahoo.com.
5
Department of Pharmaceutical Chemistry, College of Pharmacy, Taif University, Taif 5700, Saudi Arabia. eldeab1@gmail.com.

Abstract

Two series of novel 5-arylazo-3-cyano-2-(2″,3″,4″,6″-tetra-O-acetyl-β-d-galacto pyranosyloxy) pyridines and 3-cyano-2-(2″,3″,4″,6″-tetra-O-acetyl-β-d-galactopyranosyloxy) pyridines were synthesized in high yields utilizing a microwave-assisted synthesis tool guided by the principles of green chemistry. The chemical structures of the new substances were confirmed on the basis of their elemental analysis and spectroscopic data (FT-IR, 1D, 2D-NMR). Activity against different bacterial strains was studied. The anticancer potential of the new compounds is also discussed. Molecular docking was used as a tool in this research work to get better insight into the possible interactions, affinities, and expected modes of binding of the most promising derivatives of the potential chemotherapeutic target (DHFR).

KEYWORDS:

anticancer activity; antimicrobial; green chemistry; microwave synthesis; molecular docking; pyridine galactosides

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