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Items: 1 to 20 of 21

1.

Nicotine induces resilience to chronic social defeat stress in a mouse model of water pipe tobacco exposure by activating BDNF signaling.

Khalifeh M, Hobeika R, El Hayek L, Saad J, Eid F, El-Khoury R, Ghayad LM, Jabre V, Nasrallah P, Barmo N, Stephan JS, Khnayzer R, Khalil C, Sleiman SF.

Behav Brain Res. 2020 Mar 16;382:112499. doi: 10.1016/j.bbr.2020.112499. Epub 2020 Jan 21.

PMID:
31978493
2.

Exercise factors as potential mediators of cognitive rehabilitation following traumatic brain injury.

Stephan JS, Sleiman SF.

Curr Opin Neurol. 2019 Dec;32(6):808-814. doi: 10.1097/WCO.0000000000000754.

PMID:
31567547
3.

Branched-chain amino acids mediate resilience to chronic social defeat stress by activating BDNF/TRKB signaling.

Nasrallah P, Haidar EA, Stephan JS, El Hayek L, Karnib N, Khalifeh M, Barmo N, Jabre V, Houbeika R, Ghanem A, Nasser J, Zeeni N, Bassil M, Sleiman SF.

Neurobiol Stress. 2019 May 14;11:100170. doi: 10.1016/j.ynstr.2019.100170. eCollection 2019 Nov.

4.

Lactate Mediates the Effects of Exercise on Learning and Memory through SIRT1-Dependent Activation of Hippocampal Brain-Derived Neurotrophic Factor (BDNF).

El Hayek L, Khalifeh M, Zibara V, Abi Assaad R, Emmanuel N, Karnib N, El-Ghandour R, Nasrallah P, Bilen M, Ibrahim P, Younes J, Abou Haidar E, Barmo N, Jabre V, Stephan JS, Sleiman SF.

J Neurosci. 2019 Mar 27;39(13):2369-2382. doi: 10.1523/JNEUROSCI.1661-18.2019. Epub 2019 Jan 28.

5.

Lactate is an antidepressant that mediates resilience to stress by modulating the hippocampal levels and activity of histone deacetylases.

Karnib N, El-Ghandour R, El Hayek L, Nasrallah P, Khalifeh M, Barmo N, Jabre V, Ibrahim P, Bilen M, Stephan JS, Holson EB, Ratan RR, Sleiman SF.

Neuropsychopharmacology. 2019 May;44(6):1152-1162. doi: 10.1038/s41386-019-0313-z. Epub 2019 Jan 8.

PMID:
30647450
6.

Exercise promotes the expression of brain derived neurotrophic factor (BDNF) through the action of the ketone body β-hydroxybutyrate.

Sleiman SF, Henry J, Al-Haddad R, El Hayek L, Abou Haidar E, Stringer T, Ulja D, Karuppagounder SS, Holson EB, Ratan RR, Ninan I, Chao MV.

Elife. 2016 Jun 2;5. pii: e15092. doi: 10.7554/eLife.15092.

7.

Epigenetic changes in diabetes.

Al-Haddad R, Karnib N, Assaad RA, Bilen Y, Emmanuel N, Ghanem A, Younes J, Zibara V, Stephan JS, Sleiman SF.

Neurosci Lett. 2016 Jun 20;625:64-9. doi: 10.1016/j.neulet.2016.04.046. Epub 2016 Apr 27. Review.

PMID:
27130819
8.

Therapeutic targeting of oxygen-sensing prolyl hydroxylases abrogates ATF4-dependent neuronal death and improves outcomes after brain hemorrhage in several rodent models.

Karuppagounder SS, Alim I, Khim SJ, Bourassa MW, Sleiman SF, John R, Thinnes CC, Yeh TL, Demetriades M, Neitemeier S, Cruz D, Gazaryan I, Killilea DW, Morgenstern L, Xi G, Keep RF, Schallert T, Tappero RV, Zhong J, Cho S, Maxfield FR, Holman TR, Culmsee C, Fong GH, Su Y, Ming GL, Song H, Cave JW, Schofield CJ, Colbourne F, Coppola G, Ratan RR.

Sci Transl Med. 2016 Mar 2;8(328):328ra29. doi: 10.1126/scitranslmed.aac6008.

9.

Downstream Consequences of Exercise Through the Action of BDNF.

Sleiman SF, Chao MV.

Brain Plast. 2015 Oct 9;1(1):143-148. doi: 10.3233/BPL-150017.

10.

Hydroxamate-based histone deacetylase inhibitors can protect neurons from oxidative stress via a histone deacetylase-independent catalase-like mechanism.

Olson DE, Sleiman SF, Bourassa MW, Wagner FF, Gale JP, Zhang YL, Ratan RR, Holson EB.

Chem Biol. 2015 Apr 23;22(4):439-445. doi: 10.1016/j.chembiol.2015.03.014. Epub 2015 Apr 16.

11.

Hydroxamic acid-based histone deacetylase (HDAC) inhibitors can mediate neuroprotection independent of HDAC inhibition.

Sleiman SF, Olson DE, Bourassa MW, Karuppagounder SS, Zhang YL, Gale J, Wagner FF, Basso M, Coppola G, Pinto JT, Holson EB, Ratan RR.

J Neurosci. 2014 Oct 22;34(43):14328-37. doi: 10.1523/JNEUROSCI.1010-14.2014. Erratum in: J Neurosci. 2015 Jan 7;35(1):438.

12.

In vitro ischemia suppresses hypoxic induction of hypoxia-inducible factor-1α by inhibition of synthesis and not enhanced degradation.

Karuppagounder SS, Basso M, Sleiman SF, Ma TC, Speer RE, Smirnova NA, Gazaryan IG, Ratan RR.

J Neurosci Res. 2013 Aug;91(8):1066-75. doi: 10.1002/jnr.23204. Epub 2013 Mar 4.

13.

Hypoxia-inducible factor prolyl hydroxylases as targets for neuroprotection by "antioxidant" metal chelators: From ferroptosis to stroke.

Speer RE, Karuppagounder SS, Basso M, Sleiman SF, Kumar A, Brand D, Smirnova N, Gazaryan I, Khim SJ, Ratan RR.

Free Radic Biol Med. 2013 Sep;62:26-36. doi: 10.1016/j.freeradbiomed.2013.01.026. Epub 2013 Jan 31. Review.

14.

Histone Deacetylase Inhibitors and Mithramycin A Impact a Similar Neuroprotective Pathway at a Crossroad between Cancer and Neurodegeneration.

Sleiman SF, Berlin J, Basso M, Karuppagounder SS, Rohr J, Ratan RR.

Pharmaceuticals (Basel). 2011 Aug 22;4(8):1183-1195.

15.

Transglutaminase inhibition protects against oxidative stress-induced neuronal death downstream of pathological ERK activation.

Basso M, Berlin J, Xia L, Sleiman SF, Ko B, Haskew-Layton R, Kim E, Antonyak MA, Cerione RA, Iismaa SE, Willis D, Cho S, Ratan RR.

J Neurosci. 2012 May 9;32(19):6561-9. doi: 10.1523/JNEUROSCI.3353-11.2012. Erratum in: J Neurosci. 2012 Aug 8;32(32):11157.

16.

Developmental functions for the Caenorhabditis elegans Sp protein SPTF-3.

Ulm EA, Sleiman SF, Chamberlin HM.

Mech Dev. 2011 Sep-Dec;128(7-10):428-41. doi: 10.1016/j.mod.2011.08.003. Epub 2011 Aug 23.

17.

Mithramycin is a gene-selective Sp1 inhibitor that identifies a biological intersection between cancer and neurodegeneration.

Sleiman SF, Langley BC, Basso M, Berlin J, Xia L, Payappilly JB, Kharel MK, Guo H, Marsh JL, Thompson LM, Mahishi L, Ahuja P, MacLellan WR, Geschwind DH, Coppola G, Rohr J, Ratan RR.

J Neurosci. 2011 May 4;31(18):6858-70. doi: 10.1523/JNEUROSCI.0710-11.2011. Erratum in: J Neurosci. 2012 May 9;32(19):6743.

18.

Inhibition of transglutaminase 2 mitigates transcriptional dysregulation in models of Huntington disease.

McConoughey SJ, Basso M, Niatsetskaya ZV, Sleiman SF, Smirnova NA, Langley BC, Mahishi L, Cooper AJ, Antonyak MA, Cerione RA, Li B, Starkov A, Chaturvedi RK, Beal MF, Coppola G, Geschwind DH, Ryu H, Xia L, Iismaa SE, Pallos J, Pasternack R, Hils M, Fan J, Raymond LA, Marsh JL, Thompson LM, Ratan RR.

EMBO Mol Med. 2010 Sep;2(9):349-70. doi: 10.1002/emmm.201000084.

19.

Putting the 'HAT' back on survival signalling: the promises and challenges of HDAC inhibition in the treatment of neurological conditions.

Sleiman SF, Basso M, Mahishi L, Kozikowski AP, Donohoe ME, Langley B, Ratan RR.

Expert Opin Investig Drugs. 2009 May;18(5):573-84. doi: 10.1517/13543780902810345 . Review.

20.

Modulation of Caenorhabditis elegans transcription factor activity by HIM-8 and the related Zinc-Finger ZIM proteins.

Sun H, Nelms BL, Sleiman SF, Chamberlin HM, Hanna-Rose W.

Genetics. 2007 Oct;177(2):1221-6. Epub 2007 Aug 24.

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